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Author (up) Ernstsen, L.; Rangul, V.; Nauman, J.; Nes, B.M.; Dalen, H.; Krokstad, S.; Lavie, C.J.; Blair, S.N.; Wisloff, U. url  doi
  Title Protective Effect of Regular Physical Activity on Depression After Myocardial Infarction: The HUNT Study Type Journal Article
  Year 2016 Publication Am J Med Abbreviated Journal The American journal of medicine  
  Volume 129 Issue 1 Pages 82-88  
  Keywords Depression/*prevention & control; Female; Follow-Up Studies; Humans; Leisure Activities; Male; Middle Aged; *Motor Activity; Myocardial Infarction/*psychology; Prospective Studies; Risk Factors  
  Abstract PURPOSE: To study if physical activity within the recommended level over time was associated with risk of developing depression after the first myocardial infarction in older adults. METHODS: Men (n = 143) and women (n = 46) who had reached the age of 60 years in 2006-2008 who participated in the Nord-Trondelag Health Study (HUNT1, 1984-1986; HUNT2, 1995-1997; HUNT3, 2006-2008) without any mental illness or cardiovascular disease at baseline in HUNT2 and who experienced their first myocardial infarction before HUNT3 were included. Based on the patterns of physical activity from HUNT1 to HUNT2, the sample was divided into 4 groups: persistently inactive, from active to inactive, from inactive to active, and persistently active. The primary outcome, post-myocardial infarction depression symptoms, was measured with the Hospital, Anxiety and Depression Scale in HUNT3. RESULTS: In HUNT3, 11% of participants had depression. After multivariable adjustment, those who were persistently active had significantly lower odds of being depressed (odds ratio 0.28; 95% confidence interval, 0.08-0.98) compared with those who were persistently inactive. Additionally, a significant test for trend (P = .033) of lowering odds of depression was observed across all 4 categories of physical activity patterns at baseline. CONCLUSIONS: In this small sample of initially healthy adults, we observed a long-term protective effect of regular physical activity on the development of depression following myocardial infarction.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Nursing Science, Faculty of Health and Social Science, Sor-Trondelag University Colleg Editor  
  Language Summary Language Original Title  
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  Notes Ernstsen, LindaRangul, VegarNauman, JavaidNes, Bjarne MDalen, HavardKrokstad, SteinarLavie, Carl JBlair, Steven NWisloff, UlrikengResearch Support, Non-U.S. Gov't2015/08/25 06:00Am J Med. 2016 Jan;129(1):82-88.e1. doi: 10.1016/j.amjmed.2015.08.012. Epub 2015 Aug 21. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Ernstsen2016 Serial 1736  
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Author (up) Nauman, J.; Nes, B.M.; Lavie, C.J.; Jackson, A.S.; Sui, X.; Coombes, J.S.; Blair, S.N.; Wisloff, U. url  doi
  Title Prediction of Cardiovascular Mortality by Estimated Cardiorespiratory Fitness Independent of Traditional Risk Factors: The HUNT Study Type Journal Article
  Year 2017 Publication Mayo Clinic Proceedings Abbreviated Journal Mayo Clin Proc  
  Volume 92 Issue 2 Pages 218-227  
  Keywords Adult; Aged; *Cardiorespiratory Fitness; Cardiovascular Diseases/*mortality; Cause of Death; Female; Humans; Male; Middle Aged; Myocardial Ischemia/mortality; Norway/epidemiology; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Registries; Risk Factors; Stroke/mortality  
  Abstract OBJECTIVE: To assess the predictive value of estimated cardiorespiratory fitness (eCRF) and evaluate the additional contribution of traditional risk factors in cardiovascular disease (CVD) mortality prediction. PARTICIPANTS AND METHODS: The study included healthy men (n=18,721) and women (n=19,759) aged 30 to 74 years. A nonexercise algorithm estimated cardiorespiratory fitness. Cox proportional hazards models evaluated the primary (CVD mortality) and secondary (all-cause, ischemic heart disease, and stroke mortality) end points. The added predictive value of traditional CVD risk factors was evaluated using the Harrell C statistic and net reclassification improvement. RESULTS: After a median follow-up of 16.3 years (range, 0.04-17.4 years), there were 3863 deaths, including 1133 deaths from CVD (734 men and 399 women). Low eCRF was a strong predictor of CVD and all-cause mortality after adjusting for established risk factors. The C statistics for eCRF and CVD mortality were 0.848 (95% CI, 0.836-0.861) and 0.878 (95% CI, 0.862-0.894) for men and women, respectively, increasing to 0.851 (95% CI, 0.839-0.863) and 0.881 (95% CI, 0.865-0.897), respectively, when adding clinical variables. By adding clinical variables to eCRF, the net reclassification improvement of CVD mortality was 0.014 (95% CI, -0.023 to 0.051) and 0.052 (95% CI, -0.023 to 0.127) in men and women, respectively. CONCLUSION: Low eCRF is independently associated with CVD and all-cause mortality. The inclusion of traditional clinical CVD risk factors added little to risk discrimination and did not improve the classification of risk beyond this simple eCRF measurement, which may be proposed as a practical and cost-effective first-line approach in primary prevention settings.  
  Address K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN 0025-6196 ISBN Medium  
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  Notes PMID:27866655 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1963  
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