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Author (up) Graff, M.; Scott, R.A.; Justice, A.E.; Young, K.L.; Feitosa, M.F.; Barata, L.; Winkler, T.W.; Chu, A.Y.; Mahajan, A.; Hadley, D.; Xue, L.; Workalemahu, T.; Heard-Costa, N.L.; den Hoed, M.; Ahluwalia, T.S.; Qi, Q.; Ngwa, J.S.; Renstrom, F.; Quaye, L.; Eicher, J.D.; Hayes, J.E.; Cornelis, M.; Kutalik, Z.; Lim, E.; Luan, J.'an; Huffman, J.E.; Zhang, W.; Zhao, W.; Griffin, P.J.; Haller, T.; Ahmad, S.; Marques-Vidal, P.M.; Bien, S.; Yengo, L.; Teumer, A.; Smith, A.V.; Kumari, M.; Harder, M.N.; Justesen, J.M.; Kleber, M.E.; Hollensted, M.; Lohman, K.; Rivera, N.V.; Whitfield, J.B.; Zhao, J.H.; Stringham, H.M.; Lyytikainen, L.-P.; Huppertz, C.; Willemsen, G.; Peyrot, W.J.; Wu, Y.; Kristiansson, K.; Demirkan, A.; Fornage, M.; Hassinen, M.; Bielak, L.F.; Cadby, G.; Tanaka, T.; Magi, R.; van der Most, P.J.; Jackson, A.U.; Bragg-Gresham, J.L.; Vitart, V.; Marten, J.; Navarro, P.; Bellis, C.; Pasko, D.; Johansson, A.; Snitker, S.; Cheng, Y.-C.; Eriksson, J.; Lim, U.; Aadahl, M.; Adair, L.S.; Amin, N.; Balkau, B.; Auvinen, J.; Beilby, J.; Bergman, R.N.; Bergmann, S.; Bertoni, A.G.; Blangero, J.; Bonnefond, A.; Bonnycastle, L.L.; Borja, J.B.; Brage, S.; Busonero, F.; Buyske, S.; Campbell, H.; Chines, P.S.; Collins, F.S.; Corre, T.; Smith, G.D.; Delgado, G.E.; Dueker, N.; Dorr, M.; Ebeling, T.; Eiriksdottir, G.; Esko, T.; Faul, J.D.; Fu, M.; Faerch, K.; Gieger, C.; Glaser, S.; Gong, J.; Gordon-Larsen, P.; Grallert, H.; Grammer, T.B.; Grarup, N.; van Grootheest, G.; Harald, K.; Hastie, N.D.; Havulinna, A.S.; Hernandez, D.; Hindorff, L.; Hocking, L.J.; Holmens, O.L.; Holzapfel, C.; Hottenga, J.J.; Huang, J.; Huang, T.; Hui, J.; Huth, C.; Hutri-Kahonen, N.; James, A.L.; Jansson, J.-O.; Jhun, M.A.; Juonala, M.; Kinnunen, L.; Koistinen, H.A.; Kolcic, I.; Komulainen, P.; Kuusisto, J.; Kvaloy, K.; Kahonen, M.; Lakka, T.A.; Launer, L.J.; Lehne, B.; Lindgren, C.M.; Lorentzon, M.; Luben, R.; Marre, M.; Milaneschi, Y.; Monda, K.L.; Montgomery, G.W.; De Moor, M.H.M.; Mulas, A.; Muller-Nurasyid, M.; Musk, A.W.; Mannikko, R.; Mannisto, S.; Narisu, N.; Nauck, M.; Nettleton, J.A.; Nolte, I.M.; Oldehinkel, A.J.; Olden, M.; Ong, K.K.; Padmanabhan, S.; Paternoster, L.; Perez, J.; Perola, M.; Peters, A.; Peters, U.; Peyser, P.A.; Prokopenko, I.; Puolijoki, H.; Raitakari, O.T.; Rankinen, T.; Rasmussen-Torvik, L.J.; Rawal, R.; Ridker, P.M.; Rose, L.M.; Rudan, I.; Sarti, C.; Sarzynski, M.A.; Savonen, K.; Scott, W.R.; Sanna, S.; Shuldiner, A.R.; Sidney, S.; Silbernagel, G.; Smith, B.H.; Smith, J.A.; Snieder, H.; Stancakova, A.; Sternfeld, B.; Swift, A.J.; Tammelin, T.; Tan, S.-T.; Thorand, B.; Thuillier, D.; Vandenput, L.; Vestergaard, H.; van Vliet-Ostaptchouk, J.V.; Vohl, M.-C.; Volker, U.; Waeber, G.; Walker, M.; Wild, S.; Wong, A.; Wright, A.F.; Zillikens, M.C.; Zubair, N.; Haiman, C.A.; Lemarchand, L.; Gyllensten, U.; Ohlsson, C.; Hofman, A.; Rivadeneira, F.; Uitterlinden, A.G.; Perusse, L.; Wilson, J.F.; Hayward, C.; Polasek, O.; Cucca, F.; Hveem, K.; Hartman, C.A.; Tonjes, A.; Bandinelli, S.; Palmer, L.J.; Kardia, S.L.R.; Rauramaa, R.; Sorensen, T.I.A.; Tuomilehto, J.; Salomaa, V.; Penninx, B.W.J.H.; de Geus, E.J.C.; Boomsma, D.I.; Lehtimaki, T.; Mangino, M.; Laakso, M.; Bouchard, C.; Martin, N.G.; Kuh, D.; Liu, Y.; Linneberg, A.; Marz, W.; Strauch, K.; Kivimaki, M.; Harris, T.B.; Gudnason, V.; Volzke, H.; Qi, L.; Jarvelin, M.-R.; Chambers, J.C.; Kooner, J.S.; Froguel, P.; Kooperberg, C.; Vollenweider, P.; Hallmans, G.; Hansen, T.; Pedersen, O.; Metspalu, A.; Wareham, N.J.; Langenberg, C.; Weir, D.R.; Porteous, D.J.; Boerwinkle, E.; Chasman, D.I.; Abecasis, G.R.; Barroso, I.; McCarthy, M.I.; Frayling, T.M.; O'Connell, J.R.; van Duijn, C.M.; Boehnke, M.; Heid, I.M.; Mohlke, K.L.; Strachan, D.P.; Fox, C.S.; Liu, C.-T.; Hirschhorn, J.N.; Klein, R.J.; Johnson, A.D.; Borecki, I.B.; Franks, P.W.; North, K.E.; Cupples, L.A.; Loos, R.J.F.; Kilpelainen, T.O. url  doi
  Title Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults Type Meta-Analysis
  Year 2017 Publication PLoS Genetics Abbreviated Journal PLoS Genet  
  Volume 13 Issue 4 Pages e1006528  
  Keywords Adiposity/*genetics/physiology; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics; Body Mass Index; Epigenomics; *Exercise; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Obesity/*genetics/physiopathology; Waist Circumference; Waist-Hip Ratio  
  Abstract Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.  
  Address The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America  
  Corporate Author PAGE Consortium Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1553-7390 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28448500; PMCID:PMC5407576 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1909  
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Author (up) Justice, A.E.; Winkler, T.W.; Feitosa, M.F.; Graff, M.; Fisher, V.A.; Young, K.; Barata, L.; Deng, X.; Czajkowski, J.; Hadley, D.; Ngwa, J.S.; Ahluwalia, T.S.; Chu, A.Y.; Heard-Costa, N.L.; Lim, E.; Perez, J.; Eicher, J.D.; Kutalik, Z.; Xue, L.; Mahajan, A.; Renstrom, F.; Wu, J.; Qi, Q.; Ahmad, S.; Alfred, T.; Amin, N.; Bielak, L.F.; Bonnefond, A.; Bragg, J.; Cadby, G.; Chittani, M.; Coggeshall, S.; Corre, T.; Direk, N.; Eriksson, J.; Fischer, K.; Gorski, M.; Neergaard Harder, M.; Horikoshi, M.; Huang, T.; Huffman, J.E.; Jackson, A.U.; Justesen, J.M.; Kanoni, S.; Kinnunen, L.; Kleber, M.E.; Komulainen, P.; Kumari, M.; Lim, U.; Luan, J.'an; Lyytikainen, L.-P.; Mangino, M.; Manichaikul, A.; Marten, J.; Middelberg, R.P.S.; Muller-Nurasyid, M.; Navarro, P.; Perusse, L.; Pervjakova, N.; Sarti, C.; Smith, A.V.; Smith, J.A.; Stancakova, A.; Strawbridge, R.J.; Stringham, H.M.; Sung, Y.J.; Tanaka, T.; Teumer, A.; Trompet, S.; van der Laan, S.W.; van der Most, P.J.; Van Vliet-Ostaptchouk, J.V.; Vedantam, S.L.; Verweij, N.; Vink, J.M.; Vitart, V.; Wu, Y.; Yengo, L.; Zhang, W.; Hua Zhao, J.; Zimmermann, M.E.; Zubair, N.; Abecasis, G.R.; Adair, L.S.; Afaq, S.; Afzal, U.; Bakker, S.J.L.; Bartz, T.M.; Beilby, J.; Bergman, R.N.; Bergmann, S.; Biffar, R.; Blangero, J.; Boerwinkle, E.; Bonnycastle, L.L.; Bottinger, E.; Braga, D.; Buckley, B.M.; Buyske, S.; Campbell, H.; Chambers, J.C.; Collins, F.S.; Curran, J.E.; de Borst, G.J.; de Craen, A.J.M.; de Geus, E.J.C.; Dedoussis, G.; Delgado, G.E.; den Ruijter, H.M.; Eiriksdottir, G.; Eriksson, A.L.; Esko, T.; Faul, J.D.; Ford, I.; Forrester, T.; Gertow, K.; Gigante, B.; Glorioso, N.; Gong, J.; Grallert, H.; Grammer, T.B.; Grarup, N.; Haitjema, S.; Hallmans, G.; Hamsten, A.; Hansen, T.; Harris, T.B.; Hartman, C.A.; Hassinen, M.; Hastie, N.D.; Heath, A.C.; Hernandez, D.; Hindorff, L.; Hocking, L.J.; Hollensted, M.; Holmen, O.L.; Homuth, G.; Jan Hottenga, J.; Huang, J.; Hung, J.; Hutri-Kahonen, N.; Ingelsson, E.; James, A.L.; Jansson, J.-O.; Jarvelin, M.-R.; Jhun, M.A.; Jorgensen, M.E.; Juonala, M.; Kahonen, M.; Karlsson, M.; Koistinen, H.A.; Kolcic, I.; Kolovou, G.; Kooperberg, C.; Kramer, B.K.; Kuusisto, J.; Kvaloy, K.; Lakka, T.A.; Langenberg, C.; Launer, L.J.; Leander, K.; Lee, N.R.; Lind, L.; Lindgren, C.M.; Linneberg, A.; Lobbens, S.; Loh, M.; Lorentzon, M.; Luben, R.; Lubke, G.; Ludolph-Donislawski, A.; Lupoli, S.; Madden, P.A.F.; Mannikko, R.; Marques-Vidal, P.; Martin, N.G.; McKenzie, C.A.; McKnight, B.; Mellstrom, D.; Menni, C.; Montgomery, G.W.; Musk, A.B.; Narisu, N.; Nauck, M.; Nolte, I.M.; Oldehinkel, A.J.; Olden, M.; Ong, K.K.; Padmanabhan, S.; Peyser, P.A.; Pisinger, C.; Porteous, D.J.; Raitakari, O.T.; Rankinen, T.; Rao, D.C.; Rasmussen-Torvik, L.J.; Rawal, R.; Rice, T.; Ridker, P.M.; Rose, L.M.; Bien, S.A.; Rudan, I.; Sanna, S.; Sarzynski, M.A.; Sattar, N.; Savonen, K.; Schlessinger, D.; Scholtens, S.; Schurmann, C.; Scott, R.A.; Sennblad, B.; Siemelink, M.A.; Silbernagel, G.; Slagboom, P.E.; Snieder, H.; Staessen, J.A.; Stott, D.J.; Swertz, M.A.; Swift, A.J.; Taylor, K.D.; Tayo, B.O.; Thorand, B.; Thuillier, D.; Tuomilehto, J.; Uitterlinden, A.G.; Vandenput, L.; Vohl, M.-C.; Volzke, H.; Vonk, J.M.; Waeber, G.; Waldenberger, M.; Westendorp, R.G.J.; Wild, S.; Willemsen, G.; Wolffenbuttel, B.H.R.; Wong, A.; Wright, A.F.; Zhao, W.; Zillikens, M.C.; Baldassarre, D.; Balkau, B.; Bandinelli, S.; Boger, C.A.; Boomsma, D.I.; Bouchard, C.; Bruinenberg, M.; Chasman, D.I.; Chen, Y.-D.I.; Chines, P.S.; Cooper, R.S.; Cucca, F.; Cusi, D.; Faire, U. de; Ferrucci, L.; Franks, P.W.; Froguel, P.; Gordon-Larsen, P.; Grabe, H.-J.; Gudnason, V.; Haiman, C.A.; Hayward, C.; Hveem, K.; Johnson, A.D.; Wouter Jukema, J.; Kardia, S.L.R.; Kivimaki, M.; Kooner, J.S.; Kuh, D.; Laakso, M.; Lehtimaki, T.; Marchand, L.L.; Marz, W.; McCarthy, M.I.; Metspalu, A.; Morris, A.P.; Ohlsson, C.; Palmer, L.J.; Pasterkamp, G.; Pedersen, O.; Peters, A.; Peters, U.; Polasek, O.; Psaty, B.M.; Qi, L.; Rauramaa, R.; Smith, B.H.; Sorensen, T.I.A.; Strauch, K.; Tiemeier, H.; Tremoli, E.; van der Harst, P.; Vestergaard, H.; Vollenweider, P.; Wareham, N.J.; Weir, D.R.; Whitfield, J.B.; Wilson, J.F.; Tyrrell, J.; Frayling, T.M.; Barroso, I.; Boehnke, M.; Deloukas, P.; Fox, C.S.; Hirschhorn, J.N.; Hunter, D.J.; Spector, T.D.; Strachan, D.P.; van Duijn, C.M.; Heid, I.M.; Mohlke, K.L.; Marchini, J.; Loos, R.J.F.; Kilpelainen, T.O.; Liu, C.-T.; Borecki, I.B.; North, K.E.; Cupples, L.A. url  doi
  Title Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits Type Journal Article
  Year 2017 Publication Nature Communications Abbreviated Journal Nat Commun  
  Volume 8 Issue Pages 14977  
  Keywords  
  Abstract Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.  
  Address NHLBI Framingham Heart Study, Framingham, Massachusetts, 01702 USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2041-1723 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28443625; PMCID:PMC5414044 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1937  
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