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Author (up) Myklestad, K.; Vatten, L.J.; Magnussen, E.B.; Salvesen, K.A.; Romundstad, P.R. url  doi
  Title Do parental heights influence pregnancy length?: A population-based prospective study, HUNT 2 Type Journal Article
  Year 2013 Publication BMC Pregnancy and Childbirth Abbreviated Journal BMC Pregnancy Childbirth  
  Volume 13 Issue Pages 33  
  Keywords Adult; *Body Height; Female; *Gestational Age; Humans; Linear Models; Logistic Models; Male; Menstruation; Norway/epidemiology; Odds Ratio; Pregnancy; Premature Birth/*epidemiology/ultrasonography; Prospective Studies; Registries; *Term Birth; Ultrasonography, Prenatal  
  Abstract BACKGROUND: The objective of this study was to examine the association of maternal and paternal height with pregnancy length, and with the risk of pre- and post-term birth. In addition we aimed to study whether cardiovascular risk factors could explain possible associations. METHODS: Parents who participated in the Nord-Trondelag Health Study (HUNT 2; 1995-1997) were linked to offspring data from the Medical Birth Registry of Norway (1997-2005). The main analyses included 3497 women who had delivered 5010 children, and 2005 men who had fathered 2798 pregnancies. All births took place after parental participation in HUNT 2. Linear regression was used to estimate crude and adjusted differences in pregnancy length according to parental heights. Logistic regression was used to estimate crude and adjusted associations of parental heights with the risk of pre- and post-term births. RESULTS: We found a gradual increase in pregnancy length by increasing maternal height, and the association was essentially unchanged after adjustment for maternal cardiovascular risk factors, parental age, offspring sex, parity, and socioeconomic measures. When estimated date of delivery was based on ultrasound, the difference between mothers in the lower height quintile (<163 cm cm) and mothers in the upper height quintile (>/= 173 cm) was 4.3 days, and when estimated date of delivery was based on last menstrual period (LMP), the difference was 2.8 days. Shorter women (< 163 cm) had lower risk of post-term births, and when estimated date of delivery was based on ultrasound they also had higher risk of pre-term births. Paternal height was not associated with pregnancy length, or with the risks of pre- and post-term births. CONCLUSIONS: Women with shorter stature had shorter pregnancy length and lower risk of post-term births than taller women, and when EDD was based on ultrasound, they also had higher risk of preterm births. The effect of maternal height was generally stronger when pregnancy length was based on second trimester ultrasound compared to last menstrual period. The association of maternal height with pregnancy length could not be explained by cardiovascular risk factors. Paternal height was neither associated with pregnancy length nor with the risk of pre- and post-term birth.  
  Address Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim N-7489, Norway. kirsti.myklestad@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-2393 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23383756; PMC3608172 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1417  
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Author (up) Myklestad, K.; Vatten, L.J.; Magnussen, E.B.; Salvesen, K.A.; Smith, G.D.; Romundstad, P.R. url  doi
  Title Offspring birth weight and cardiovascular risk in parents: a population-based HUNT 2 study Type Journal Article
  Year 2012 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 175 Issue 6 Pages 546-555  
  Keywords Adult; *Birth Weight; Blood Glucose/metabolism; Blood Pressure; Body Mass Index; Cardiovascular Diseases/*genetics; Female; Gestational Age; Health Surveys; Humans; *Infant, Low Birth Weight; Infant, Newborn; Lipids/blood; Male; Models, Statistical; Norway; *Parents; Pregnancy; Registries; Risk Factors; Waist Circumference  
  Abstract Low birth weight is associated with increased risk of cardiovascular disease and type 2 diabetes in later life. The fetal insulin hypothesis suggests that shared genetic factors partly explain this association. If fetal genes predispose to both low birth weight and cardiovascular disease in adulthood, fathers of offspring with low birth weight should display an unfavorable profile of cardiovascular risk factors. To study this, the authors linked data on more than 14,000 parents, collected from the second Health Study of Nord Trondelag County, Norway (HUNT 2, 1995-1997), to offspring data from the Norwegian Medical Birth Registry (1967-2005). Linear regression was used to study associations of offspring birth weight for gestational age with the parents' body mass index, waist circumference, blood pressure, glucose, and serum lipids. All analyses were adjusted for shared environment by means of the socioeconomic measures, lifestyle, and cardiovascular risk factors of the partner. The authors found that low offspring birth weight for gestational age was associated with increased paternal blood pressure, body mass index, waist circumference, and unfavorable levels of glucose and lipids. For mothers, associations similar to those for fathers were found for blood pressure, whereas associations in the opposite direction were found for glucose, lipids, and body mass index. The paternal findings strengthen the genetic hypothesis.  
  Address Department of Public Health, Norwegian University of Science and Technology, Norways. kirsti.myklestad@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22328703 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1556  
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