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Author (up) Asberg, A.N.; Stovner, L.J.; Zwart, J.-A.; Winsvold, B.S.; Heuch, I.; Hagen, K. url  doi
  Title Migraine as a predictor of mortality: The HUNT study Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords Headache; general population; migraine; mortality; HUNT2  
  Abstract BACKGROUND: There is conflicting evidence for the association between migraine and increased mortality risk. The aim of this study was to investigate the relationship between migraine and non-migrainous headache, and all-cause mortality and cardiovascular mortality. METHODS: In this prospective population-based cohort study from Norway, we used baseline data from the second Nord-Trondelag Health Survey (HUNT2), performed between 1995 and 1997 in the County of Nord-Trondelag. These data were linked with a comprehensive mortality database with follow-up through the year 2011. A total of 51,853 (56% of invited) people were categorized based on their answers to the headache questions in HUNT2 (headache free, migraine or non-migrainous headache). Hazard ratios (HRs) of mortality during a mean of 14.1 years of follow-up were estimated using Cox regression. RESULTS: During the follow-up period 9408 died, 4321 of these from cardiovascular causes. There was no difference in all-cause mortality between individuals with migraine and non-migrainous headache compared to those without headache or between headache status and mortality by cardiovascular disease. There was, however, among men with migraine without aura a reduced risk of death by cardiovascular diseases (HR 0.72, 95% confidence interval 0.56-0.93). This relationship was not evident in women. CONCLUSION: In this large, prospective cohort study there was no evidence for a higher all-cause mortality or cardiovascular mortality among individuals with migraine.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian Advisory Unit of Headache, St Olavs Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26115666 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1712  
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Author (up) Asberg, A.N.; Stovner, L.J.; Zwart, J.A.; Winsvold, B.S.; Heuch, I.; Hagen, K. url  doi
  Title Chronic musculoskeletal complaints as a predictor of mortality-The HUNT study Type Journal Article
  Year 2016 Publication Pain Abbreviated Journal Pain  
  Volume 157 Issue 7 Pages 1443-1447  
  Keywords  
  Abstract The impact of chronic musculoskeletal complaints (CMSC) and chronic widespread chronic musculoskeletal complaints (CWMSC) on mortality is controversial. The aim of this study was to investigate the relationship between these conditions and mortality. In this prospective population-based cohort study from Norway, baseline data from the second Nord-Trondelag Health Survey (HUNT2, performed 1995-1997) were linked to the comprehensive National Cause of Death Registry in Norway with follow-up through the year 2011. A total of 65,026 individuals (70%) participated and were categorized based on their response to CMSC questions in HUNT2 (no CMSC, CMSC, or CWMSC). Hazard ratios (HRs) of mortality during a mean of 14.1 years of follow-up were estimated using Cox regression. During the follow-up period, 12,521 subjects died, 5162 from cardiovascular diseases, 3478 from cancer, and 3881 from all other causes. In the multivariate-adjusted analyses, there was no difference in all-cause mortality between individuals with or without CMSC (HR 1.01, confidence interval, 0.97-1.05) and CWMSC (HR 1.01, confidence interval, 0.96-1.05). Similarly, there was no association between CMSC or CWMSC and cardiovascular mortality, mortality from cancer, or mortality from all other causes. Therefore, from this study, we conclude that there is no evidence for a higher mortality rate among individuals with CMSC or CWMSC.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication aDepartment of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway bNorw Editor  
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  Notes Asberg, Anders NStovner, Lars JZwart, John-AnkerWinsvold, Bendik SHeuch, IngridHagen, Knuteng2016/02/27 06:00Pain. 2016 Jul;157(7):1443-7. doi: 10.1097/j.pain.0000000000000537. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Asberg2016a Serial 1728  
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Author (up) Haberg, A.K.; Hammer, T.A.; Kvistad, K.A.; Rydland, J.; Muller, T.B.; Eikenes, L.; Garseth, M.; Stovner, L.J. url  doi
  Title Incidental Intracranial Findings and Their Clinical Impact; The HUNT MRI Study in a General Population of 1006 Participants between 50-66 Years Type Journal Article
  Year 2016 Publication PLoS One Abbreviated Journal PloS one  
  Volume 11 Issue 3 Pages e0151080  
  Keywords Adolescent; Adult; Aged; *Brain; Brain Diseases/diagnosis/surgery; False Positive Reactions; Female; Humans; *Incidental Findings; *Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Neurosurgical Procedures; Referral and Consultation; Young Adult  
  Abstract OBJECTIVES: Evaluate types and prevalence of all, incidental, and clinically relevant incidental intracranial findings, i.e. those referred to primary physician or clinical specialist, in a cohort between 50 and 66 years from the Nord-Trondelag Health (HUNT) study. Types of follow-up, outcome of repeated neuroimaging and neurosurgical treatment were assessed. MATERIAL AND METHODS: 1006 participants (530 women) underwent MRI of the head at 1.5T consisting of T1 weighted sagittal IR-FSPGR volume, axial T2 weighted, gradient echo T2* weighted and FLAIR sequences plus time of flight cerebral angiography covering the circle of Willis. The nature of a finding and if it was incidental were determined from previous radiological examinations, patient records, phone interview, and/or additional neuroimaging. Handling and outcome of the clinically relevant incidental findings were prospectively recorded. True and false positives were estimated from the repeated neuroimaging. RESULTS: Prevalence of any intracranial finding was 32.7%. Incidental intracranial findings were present in 27.1% and clinically relevant findings in 15.1% of the participants in the HUNT MRI cohort. 185 individuals (18.4%) were contacted by phone about their findings. 40 participants (6.2%) underwent >/= 1 additional neuroimaging session to establish etiology. Most false positives were linked to an initial diagnosis of suspected glioma, and overall positive predictive value of initial MRI was 0.90 across different diagnoses. 90.8% of the clinically relevant incidental findings were developmental and acquired cerebrovascular pathologies, the remaining 9.2% were intracranial tumors, of which extra-axial tumors predominated. In total, 3.9% of the participants were referred to a clinical specialist, and 11.7% to their primary physician. 1.4% underwent neurosurgery/radiotherapy, and 1 (0.1%) experienced a procedure related postoperative deficit. CONCLUSIONS: In a general population between 50 and 66 years most intracranial findings on MRI were incidental, and >15% of the cohort was referred to clinical-follow up. Hence good routines for handling of findings need to be in place to ensure timely and appropriate handling.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Editor  
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  Notes Haberg, Asta KristineHammer, Tommy ArildKvistad, Kjell ArneRydland, JanaMuller, Tomm BEikenes, LiveGarseth, MariStovner, Lars JacobengResearch Support, Non-U.S. Gov't2016/03/08 06:00PLoS One. 2016 Mar 7;11(3):e0151080. doi: 10.1371/journal.pone.0151080. eCollection 2016. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Haberg2016 Serial 1743  
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Author (up) Hagen, K.; Asvold, B.O.; Midthjell, K.; Stovner, L.J.; Zwart, J.-A.; Linde, M. url  doi
  Title Inverse relationship between type 1 diabetes mellitus and migraine. Data from the Nord-Trondelag Health Surveys 1995-1997 and 2006-2008 Type Journal Article
  Year 2018 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 38 Issue 3 Pages 417-426  
  Keywords *Epidemiology; *diabetes mellitus; *headache; *migraine  
  Abstract Aims The aim of this cross-sectional population-based study was to investigate the associations between migraine and type 1 and type 2 diabetes mellitus (DM). Methods We used data from the second (1995-1997) and third survey (2006-2008) in the Nord-Trondelag Health Study. Analyses were made for the 26,121 participants (30-97 years of age, median 58.3 years) with known headache and DM status in both surveys, and for the 39,584 participants in the third survey (20-97 years, median 54.1 years). The diagnosis of migraine was given to those who fulfilled the questionnaire-based migraine diagnosis in the second and/or third survey. Associations were assessed using multiple logistic regression, estimating prevalence odds ratio (OR) with 95% confidence intervals (CIs). Results In the multivariate analysis of the 26,121 participants in both surveys, adjusting for age, gender, years of education, and smoking, classical type 1 DM (n = 81) was associated with a lower prevalence of any headache (OR = 0.55, 95% CI 0.34-0.88),and migraine (OR = 0.47, 95% CI 0.26-0.96) compared to those without DM (n = 24,779). Correspondingly, the merged group of classical type 1 DM and latent autoimmune diabetes of adults (LADA) (n = 153) were less likely to have migraine (OR = 0.53, 95% CI 0.31-0.91). Similarly, an inverse relationship between type 1 DM and migraine was found in analyses of 39,584 participants in the third survey. No clear association was found between headache and type 2 DM. Conclusions In this cross-sectional population-based study of mainly middle-aged participants, type 1 DM was inversely associated with headache, in particular migraine.  
  Address 2 Norwegian Advisory Unit on Headache, St. Olavs Hospital, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28114807 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2087  
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Author (up) Hagen, K.; Linde, M.; Steiner, T.J.; Stovner, L.J.; Zwart, J.-A. url  doi
  Title Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trondelag Health Studies Type Journal Article
  Year 2012 Publication Pain Abbreviated Journal Pain  
  Volume 153 Issue 1 Pages 56-61  
  Keywords Adult; Aged; Analgesics/*adverse effects; Female; Follow-Up Studies; Headache Disorders, Secondary/chemically induced/*epidemiology; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Norway/epidemiology; Prevalence; Risk Factors  
  Abstract Medication-overuse headache (MOH) is relatively common, but its incidence has not been calculated and there are no prospective population-based studies that have evaluated risk factors for developing MOH. The aim of this study was to estimate incidences of and identify risk factors for developing chronic daily headache (CDH) and MOH. This longitudinal population-based cohort study used data from the Nord-Trondelag Health Surveys performed in 1995-1997 and 2006-2008. Among the 51,383 participants at baseline, 41,766 were eligible approximately 11 years later. There were 26,197 participants (responder rate 63%), among whom 25,596 did not report CDH at baseline in 1995-1997. Of these, 201 (0.8%) had MOH and 246 (1.0%) had CDH without medication overuse (CDHwoO) 11 years later. The incidence of MOH was 0.72 per 1000 person-years (95% confidence interval 0.62-0.81). In the multivariate analyses, a 5-fold risk for developing MOH was found among individuals who at baseline reported regular use of tranquilizers [odds ratio 5.2 (3.0-9.0)] or who had a combination of chronic musculoskeletal complaints, gastrointestinal complaints, and Hospital Anxiety and Depression Scale score >/= 11 [odds ratio 4.7 (2.4-9.0)]. Smoking and physical inactivity more than doubled the risk of MOH. In contrast, these factors did not increase the risk of CDHwoO. In this large population-based 11-year follow-up study, several risk factors for MOH did not increase the risk for CDHwoO, suggesting these are pathogenetically distinct. If the noted associations are causal, more focus on comorbid condition, physical activity, and use of tobacco and tranquilizers may limit the development of MOH.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no  
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  Series Volume Series Issue Edition  
  ISSN 0304-3959 ISBN Medium  
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  Notes PMID:22018971 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1527  
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Author (up) Hagen, K.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title The bidirectional relationship between headache and chronic musculoskeletal complaints: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2012 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume 19 Issue 11 Pages 1447-1454  
  Keywords Cohort Studies; Female; Follow-Up Studies; Headache Disorders/*complications/*epidemiology; Humans; Male; Middle Aged; Musculoskeletal Pain/*complications/*epidemiology; Questionnaires  
  Abstract BACKGROUND AND PURPOSE: Chronic daily headache (CDH) and chronic musculoskeletal complaints (CMSCs) are associated disorders, but whether there is a causal relationship between them is unclear. OBJECTIVE: To determine whether CMSCs are associated with the subsequent development of CDH and vice versa. METHODS: This longitudinal population-based cohort study used data from two consecutive surveys in the Nord-Trondelag Health Study (HUNT 2 and 3) performed in 1995-1997 and 2006-2008. Amongst the 51 383 participants aged >/= 20 years at baseline, 41 766 were eligible approximately 11 years later. Of these, 26 197 (63%) completed the questions regarding headache and CMSCs in HUNT 3. RESULTS: A bidirectional relationship was found between headache and CMSCs. In the multivariate analyses adjusting for known potential confounders, a nearly two fold risk (OR 1.8; 95% CI 1.5-2.3) for developing CDH was found for those with CMSCs at baseline. Vice versa, a similarly elevated risk of CMSCs (OR 1.8; 95% CI 1.2-2.6), and even higher risk of chronic widespread MSCs (OR 2.7; 95% CI 1.6-4.7), was found at follow-up amongst those with CDH at baseline. CONCLUSION: CMSCs predispose to CDH and CDH predisposes to CMSCs 11 years later. This may have relevance to understanding the pathophysiology of these disorders. CMSCs should be treated not only to relieve them but also to prevent the development of CDH, and vice versa.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
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  Notes PMID:22519547 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1528  
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Author (up) Hagen, K.; Stordal, E.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title Headache as a risk factor for dementia: a prospective population-based study Type Journal Article
  Year 2014 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 34 Issue 5 Pages 327-335  
  Keywords Alzheimer’s disease; headache; migraine; vascular dementia  
  Abstract BACKGROUND: Headache has not been established as a risk factor for dementia. The aim of this study was to determine whether any headache was associated with subsequent development of vascular dementia (VaD), Alzheimer's disease (AD) or other types of dementia. METHODS: This prospective population-based cohort study used baseline data from the Nord-Trondelag Health Study (HUNT 2) performed during 1995-1997 and, from the same Norwegian county, a register of cases diagnosed with dementia during 1997-2010. Participants aged >/=20 years who responded to headache questions in HUNT 2 were categorized (headache free; with any headache; with migraine; with non-migrainous headache). Hazard ratios (HRs) for later inclusion in the dementia register were estimated using Cox regression analysis. RESULTS: Of 51,383 participants providing headache data in HUNT 2, 378 appeared in the dementia register during the follow-up period. Compared to those who were headache free, participants with any headache had increased risk of VaD ( N = 63) (multivariate-adjusted HR = 2.3, 95% CI 1.4-3.8, P = 0.002) and of mixed dementia (VaD and AD ( N = 52)) (adjusted HR = 2.0, 95% CI 1.1-3.5, P = 0.018). There was no association between any headache and later development of AD ( N = 180). CONCLUSION: In this prospective population-based cohort study, any headache was a risk factor for development of VaD.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24265286 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1598  
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Author (up) Hagen, K.; Stordal, E.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title Headache as a risk factor for dementia: A prospective population-based study Type Journal Article
  Year 2013 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords Alzheimer’s disease; headache; migraine; vascular dementia  
  Abstract BACKGROUND: Headache has not been established as a risk factor for dementia. The aim of this study was to determine whether any headache was associated with subsequent development of vascular dementia (VaD), Alzheimer's disease (AD) or other types of dementia. METHODS: This prospective population-based cohort study used baseline data from the Nord-Trondelag Health Study (HUNT 2) performed during 1995-1997 and, from the same Norwegian county, a register of cases diagnosed with dementia during 1997-2010. Participants aged >/=20 years who responded to headache questions in HUNT 2 were categorized (headache free; with any headache; with migraine; with nonmigrainous headache). Hazard ratios (HRs) for later inclusion in the dementia register were estimated using Cox regression analysis. RESULTS: Of 51,383 participants providing headache data in HUNT 2, 378 appeared in the dementia register during the follow-up period. Compared to those who were headache free, participants with any headache had increased risk of VaD ( N = 63) (multivariate-adjusted HR = 2.3, 95% CI 1.4-3.8, P = 0.002) and of mixed dementia (VaD and AD ( N = 52)) (adjusted HR = 2.0, 95% CI 1.1-3.5, P = 0.018). There was no association between any headache and later development of AD ( N = 180). CONCLUSION: In this prospective population-based cohort study, any headache was a risk factor for development of VaD.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24265286 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1447  
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Author (up) Hagen, K.; Wisloff, U.; Ellingsen, O.; Stovner, L.J.; Linde, M.   
  Title Headache and peak oxygen uptake: The HUNT3 study Type Journal Article
  Year 2016 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume 36 Issue 5 Pages 437-444  
  Keywords  
  Abstract BACKGROUND: Evidence on the association between headache and physical fitness is conflicting. The aim of this population-based study was to examine the relationship between peak oxygen uptake (VO2peak) and headache, including migraine and tension-type headache (TTH). METHODS: In the third Nord-Trondelag Health study (HUNT3), VO2peak was measured by ergospirometry in a sample of 4631 healthy adult participants. Of these, 3899 (54% women) also answered headache questions. The cross-sectional association between headache and VO2peak was evaluated by logistic regression using a categorical approach based on quintiles. Scores in the upper quintile were used as reference. RESULTS: Participants age 20-50 years had significant trends of increasing prevalence of any headache ( ITALIC! p  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian Advisor Editor  
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  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Hagen2016 Serial 1744  
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Author (up) Hansen, A.G.; Helvik, A.-S.; Nordgard, S.; Bugten, V.; Stovner, L.J.; Haberg, A.K.; Garseth, M.; Eggesbo, H.B. url  doi
  Title Incidental findings in MRI of the paranasal sinuses in adults: a population-based study (HUNT MRI) Type Journal Article
  Year 2014 Publication BMC ear, Nose, and Throat Disorders Abbreviated Journal BMC Ear Nose Throat Disord  
  Volume 14 Issue 1 Pages 13  
  Keywords HUNT3; Fluid; Incidental findings; MRI; Mucosal thickening; Opacification; Paranasal sinuses; Polyps; Population-based study; Retention cysts  
  Abstract BACKGROUND: Diagnostic imaging of the head is used with increasing frequency, and often includes the paranasal sinuses, where incidental opacifications are found. To determine the clinical relevance of such findings can be challenging, and for the patient such incidental findings can give rise to concern if they are over-reported. Studies of incidental findings in the paranasal sinuses have been conducted mostly in patients referred for diagnostic imaging, hence the prevalence in the general population is not known. The purpose of this study was to determine the prevalence and size of incidental opacification in the paranasal sinuses in a non-selected adult population using magnetic resonance imaging (MRI) without medical indication, and to relate the results to sex and season. METHODS: Randomly and independent of medical history, 982 participants (518 women) with a mean age of 58.5 years (range, 50-66) underwent MRI of the head as part of a large public health survey in Norway. The MRIs included 3D T1 weighted volume data and 2D axial T2 weighted image (WI). Opacifications, indicating mucosal thickenings, polyps, retention cysts, or fluid, were recorded if measuring more than 1 mm. RESULTS: Opacifications were found in 66% of the participants. Mucosal thickenings were found in 49%, commonly in the maxillary sinuses (29%) where 25% had opacifications that were less than 4 mm in size. Other opacifications occurred in the anterior ethmoid (23%), posterior ethmoid (21%), frontal sinus (9%), and sphenoid (8%). Polyps and retention cysts were also found mainly in the maxillary sinuses in 32%. Fluid was observed in 6% of the MRIs. Mucosal thickening was observed more frequently in men than in women (P <0.05). No seasonal variation was found. CONCLUSIONS: In this large non-selected sample, incidental opacification in the paranasal sinuses was seen in two out of three participants, and mucosal thickening was seen in one out of two. Fluid was rare. Knowledge of incidental opacification is important because it can affect clinical practice.  
  Address Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1472-6815 ISBN Medium  
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  Notes PMID:25674037 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1671  
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Author (up) Hansen, A.G.; Helvik, A.S.; Thorstensen, W.M.; Nordgard, S.; Langhammer, A.; Bugten, V.; Stovner, L.J.; Eggesbo, H.B. url  doi
  Title Paranasal sinus opacification at MRI in lower airway disease (the HUNT study-MRI) Type Journal Article
  Year 2016 Publication Eur Arch Otorhinolaryngol Abbreviated Journal European archives of oto-rhino-laryngology  
  Volume 273 Issue 7 Pages 1761-1768  
  Keywords HUNT2; HUNT3  
  Abstract The study builds on the concept of united airways, which describes the link between the upper and lower airways. Explorations of this concept have mainly related to asthma and less to chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate paranasal sinus opacification at magnetic resonance imaging (MRI) in COPD, self-reported asthma and respiratory symptoms. In this cross-sectional study, 880 randomly selected participants in the Nord-Trondelag health survey (HUNT) (mean age 57.7 years, range 50-66 years, 463 women) were investigated using MRI of the paranasal sinuses. Participants were allocated to four mutually exclusive groups: (1) COPD (n = 20), (2) asthma (n = 89), (3) respiratory symptoms (n = 199), and (4) reference group (n = 572). Paranasal sinus opacifications were categorised as mucosal thickening, polyps and retention cysts, and fluid. In each participant, measurements >/=1 mm from all sinuses were summed to give a total for each category of opacities. The sums for these three categories were further added together, and referred to as the total sum. Using the 75th percentile cut-off values, the likelihood of having paranasal sinus opacifications was more than six times higher in participants with COPD and twice as high in participants with asthma than among the reference group. Respiratory symptoms were only associated with mucosal thickening. The present study shows that paranasal sinus opacification is associated not only with asthma, but also with COPD and respiratory symptoms. This is in accordance with the united airways hypothesis, and should be kept in mind when handling patients with these conditions.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Ear, Nose and Throat, Head and Neck Surgery, St. Olavs Hospital, Norwegian University Editor  
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  Notes Hansen, Aleksander GrandeHelvik, Anne-SofieThorstensen, Wenche MoeNordgard, StaleLanghammer, ArnulfBugten, VegardStovner, Lars JacobEggesbo, Heidi BeateengGermanyEUFOS2015/10/27 06:00Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1761-8. doi: 10.1007/s00405-015-3790-7. Epub 2015 Oct 26. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Hansen2016 Serial 1746  
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Author (up) Hansen, A.G.; Stovner, L.J.; Hagen, K.; Helvik, A.-S.; Thorstensen, W.M.; Nordgard, S.; Bugten, V.; Eggesbo, H.B. url  doi
  Title Paranasal sinus opacification in headache sufferers: A population-based imaging study (the HUNT study-MRI) Type Journal Article
  Year 2017 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 37 Issue 6 Pages 509-516  
  Keywords Paranasal sinuses; headache; magnetic resonance imaging; migraine; opacification; sinus headache; tension headache  
  Abstract Background The association between headache and paranasal sinus disease is still unclear. Because of symptom overlap, the two conditions are not easily studied on the basis of symptoms alone. The aim of the present study was to investigate whether paranasal sinus opacification on magnetic resonance imaging (MRI) was associated with migraine, tension-type headache (TTH) or unclassified headache. Methods This was a cross-sectional study of 844 randomly selected participants (442 women, age range 50-65 years, mean age 57.7 years). Based on 14 headache questions, participants were allocated to four mutually exclusive groups: migraine, TTH, unclassified headache or headache free. On MRI, opacifications as mucosal thickening, polyps/retention cysts and fluid in the five paired sinuses were measured and recorded if >/=1 mm. For each participant, opacification thickness was summed for each sinus and, in addition, a total sum of all sinuses was calculated. Opacification in each sinus was compared between headache-free participants and the headache groups using non-parametric tests, and the total sum was compared by logistical regression. Results No significant association was found between paranasal sinus opacification and headache in general, nor when headache was differentiated into migraine, TTH and unclassified headache. This was also true in separate analyses of mucosal thickening and fluid and of opacification from each paranasal sinus. Conclusion Migraine, TTH and unclassified headache were found not to be associated with an increased degree of paranasal sinus opacification at MRI.  
  Address 5 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27215544 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1921  
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Author (up) Hoem Nordhaug, L.; Vik, A.; Hagen, K.; Stovner, L.J.; Pedersen, T.; Gravdahl, G.B.; Linde, M. url  doi
  Title Headaches in patients with previous head injuries: A population-based historical cohort study (HUNT) Type Journal Article
  Year 2015 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords  
  Abstract BACKGROUND: Headache attributed to head injury is claimed to be among the most common secondary headache disorders, yet available epidemiological evidence is scarce. We evaluated the prevalence of headache among individuals previously exposed to head injury by a comparison to an uninjured control group. METHODS: This population-based historical cohort study used data from hospital records on previous exposure to head injury linked to a large epidemiological survey with data on headache occurrence. Participants without head injury, according to hospital records, were used as controls. The head injuries were classified according to the Head Injury Severity Scale (HISS) and the International Classification of Headache Disorders (ICHD-3 beta). Binary logistic regression was performed to investigate the association between headache and head injury, controlling for potential confounders. RESULTS: The exposed group consisted of 940 individuals and the control group of 38,751 individuals. In the multivariate analyses, adjusting for age, sex, anxiety, depression and socioeconomic status, there were significant associations between mild head injury and any headache, migraine, chronic daily headache and medication overuse headache. CONCLUSION: Headache was more likely among individuals previously referred to a hospital for a mild head injury compared to uninjured controls.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway lenaho Editor  
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  Notes Hoem Nordhaug, LenaVik, AnneHagen, KnutStovner, Lars JacobPedersen, TorunnGravdahl, Goril BruvikLinde, MattiasENG2015/12/05 06:00Cephalalgia. 2015 Dec 2. pii: 0333102415618948. Approved no  
  Call Number HUNT @ maria.stuifbergen @ HoemNordhaug2015 Serial 1819  
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Author (up) Honningsvag, L.-M.; Haberg, A.K.; Hagen, K.; Kvistad, K.A.; Stovner, L.J.; Linde, M. url  doi
  Title White matter hyperintensities and headache: A population-based imaging study (HUNT MRI) Type Journal Article
  Year 2018 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 38 Issue 13 Pages 1927-1939  
  Keywords 1.5 tesla; Flair; T1-weighted; leukoaraiosis; small vessel disease; white matter disease; white matter lesions  
  Abstract OBJECTIVE: To examine the relationship between white matter hyperintensities and headache. METHODS: White matter hyperintensities burden was assessed semi-quantitatively using Fazekas and Scheltens scales, and by manual and automated volumetry of MRI in a sub-study of the general population-based Nord-Trondelag Health Study (HUNT MRI). Using validated questionnaires, participants were categorized into four cross-sectional headache groups: Headache-free (n = 551), tension-type headache (n = 94), migraine (n = 91), and unclassified headache (n = 126). Prospective questionnaire data was used to further categorize participants into groups according to the evolution of headache during the last 12 years: Stable headache-free, past headache, new onset headache, and persistent headache. White matter hyperintensities burden was compared across headache groups using adjusted multivariate regression models. RESULTS: Individuals with tension-type headache were more likely to have extensive white matter hyperintensities than headache-free subjects, with this being the case across all methods of white matter hyperintensities assessment (Scheltens scale: Odds ratio, 2.46; 95% CI, 1.44-4.20). Migraine or unclassified headache did not influence the odds of having extensive white matter hyperintensities. Those with new onset headache were more likely to have extensive white matter hyperintensities than those who were stable headache-free (Scheltens scale: Odds ratio, 2.24; 95% CI, 1.13-4.44). CONCLUSIONS: Having tension-type headache or developing headache in middle age was linked to extensive white matter hyperintensities. These results were similar across all methods of assessing white matter hyperintensities. If white matter hyperintensities treatment strategies emerge in the future, this association should be taken into consideration.  
  Address 3 Norwegian Advisory Unit on Headache, St. Olav's University Hospital, Trondheim, Norway  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29528690 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2111  
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Author (up) Honningsvag, L.-M.; Hagen, K.; Haberg, A.; Stovner, L.J.; Linde, M. url  doi
  Title Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI) Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords HUNT3; Health survey; cerebral infarction; cysts; malformations; migraine; pathology; tension-type headache; unclassified headache; white matter  
  Abstract BACKGROUND: Most studies on intracranial abnormalities among headache sufferers were performed in selected clinical populations. The aim of this study was to evaluate the relationship between intracranial abnormalities and headache among middle-aged adults in the general population. METHODS: Participants in a large epidemiological study (the HUNT 3 study; 2006-2008) who answered a headache questionnaire and participated in a population-based imaging study of the head (HUNT MRI; 2007-2009) were included (n = 864; age, 50-65 at enrollment). Based on the responses to the HUNT 3 questionnaire, respondents were categorized as having migraine, tension-type headache, or unclassified headache. Logistic regression was used to compare the occurrence of intracranial abnormalities between groups. RESULTS: Intracranial abnormalities were more common in headache sufferers than in headache-free individuals (29% vs. 22%, respectively; p = 0.041). Adjusted multivariate analyses revealed that those with tension-type headache had higher odds of having minor abnormalities (odds ratio, 2.13; 95% confidence interval = 1.18-3.85). This association disappeared when those with only white matter hyperintensities were removed from the analysis. CONCLUSIONS: Headache sufferers had increased odds of minor intracranial abnormalities. The increased odds were primarily related to the presence of white matter hyperintensities.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian Advisory Unit on Headache, St. Olavs University Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25896482 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1691  
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Author (up) Honningsvag, L.-M.; Linde, M.; Haberg, A.; Stovner, L.J.; Hagen, K. url  doi
  Title Does health differ between participants and non-participants in the MRI-HUNT study, a population based neuroimaging study? The Nord-Trondelag health studies 1984-2009 Type Journal Article
  Year 2012 Publication BMC Medical Imaging Abbreviated Journal BMC Med Imaging  
  Volume 12 Issue Pages 23  
  Keywords Aged; Female; *Health Status Disparities; Humans; Magnetic Resonance Imaging/*utilization; Male; Middle Aged; Neuroimaging/*utilization; Norway/epidemiology; Patient Participation/*statistics & numerical data  
  Abstract BACKGROUND: Bias with regard to participation in epidemiological studies can have a large impact on the generalizability of results. Our aim was to investigate the direction and magnitude of potential bias by comparing health-related factors among participants and non-participants in a MRI-study based on HUNT, a large Norwegian health survey. METHODS: Of 14,033 individuals aged 50-65, who had participated in all three large public health surveys within the Norwegian county of Nord-Trondelag (HUNT 1, 2 and 3), 1,560 who lived within 45 minutes of travel from the city of Levanger were invited to a MRI study (MRI-HUNT). The sample of participants in MRI-HUNT (n = 1,006) were compared with those who were invited but did not participate (n = 554) and with those who were eligible but not invited (n = 12,473), using univariate analyses and logistic regression analyses adjusting for age and education level. RESULTS: Self-reported health did not differ between the three groups, but participants had a higher education level and were somewhat younger than the two other groups. In the adjusted multivariate analyses, obesity was consistently less prevalent among participants. Significant differences in blood pressure and cholesterol were also found. CONCLUSION: This is the first large population-based study comparing participants and non-participants in an MRI study with regard to general health. The groups were not widely different, but participants had a higher level of education, and were less likely to be obese and have hypertension, and were slightly younger than non-participants. The observed differences between participants and non-invited individuals are probably partly explained by the inclusion criterion that participants had to live within 45 minutes of transport to where the MRI examination took place. One will expect that the participants have somewhat less brain morphological changes related to cardiovascular risk factors than the general population. Such consequences underline the crucial importance of evaluation of non-participants in MRI studies.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, 7491, Norway. lassemar@stud.ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-2342 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22846223; PMC3472234 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1532  
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Author (up) Honningsvag, L.M.; Hagen, K.; Haberg, A.; Stovner, L.J.; Linde, M. url  doi
  Title Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI) Type Journal Article
  Year 2016 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume 36 Issue 2 Pages 113-121  
  Keywords HUNT3  
  Abstract BACKGROUND: Most studies on intracranial abnormalities among headache sufferers were performed in selected clinical populations. The aim of this study was to evaluate the relationship between intracranial abnormalities and headache among middle-aged adults in the general population. METHODS: Participants in a large epidemiological study (the HUNT 3 study; 2006-2008) who answered a headache questionnaire and participated in a population-based imaging study of the head (HUNT MRI; 2007-2009) were included (n = 864; age, 50-65 at enrollment). Based on the responses to the HUNT 3 questionnaire, respondents were categorized as having migraine, tension-type headache, or unclassified headache. Logistic regression was used to compare the occurrence of intracranial abnormalities between groups. RESULTS: Intracranial abnormalities were more common in headache sufferers than in headache-free individuals (29% vs. 22%, respectively; p = 0.041). Adjusted multivariate analyses revealed that those with tension-type headache had higher odds of having minor abnormalities (odds ratio, 2.13; 95% confidence interval = 1.18-3.85). This association disappeared when those with only white matter hyperintensities were removed from the analysis. CONCLUSIONS: Headache sufferers had increased odds of minor intracranial abnormalities. The increased odds were primarily related to the presence of white matter hyperintensities.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Norway lassehon@gmail.co Editor  
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  Notes Honningsvag, Lasse-MariusHagen, KnutHaberg, AstaStovner, Lars JacobLinde, MattiasengEngland2015/04/22 06:00Cephalalgia. 2016 Feb;36(2):113-21. doi: 10.1177/0333102415583147. Epub 2015 Apr 20. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Honningsvag2016 Serial 1752  
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Author (up) Husoy, A.K.; Indergaard, M.K.; Honningsvag, L.-M.; Haberg, A.K.; Hagen, K.; Linde, M.; Garseth, M.; Stovner, L.J. url  doi
  Title Perivascular spaces and headache: A population-based imaging study (HUNT-MRI) Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords HUNT1; HUNT2; HUNT3; Virchow-Robin spaces; epidemiology; headache; magnetic resonance imaging; migraine; population-based  
  Abstract BACKGROUND: In four previous clinic-based MRI studies headache sufferers (in particular migraineurs) had more perivascular spaces (PVS) than individuals who were headache-free. METHODS: The present study was part of a large longitudinal, epidemiological study (Nord-Trondelag Health Survey (HUNT)). The 1006 participants, age 50-65 years at inclusion, had participated in all previous HUNT surveys (1-3), and been randomly selected to a population-based imaging study of the head (HUNT-MRI, 2007-2009). The number of visible PVS in the basal ganglia (BG) and hemispheric white matter (HWM) was compared in headache sufferers (migraine with and without aura, non-migrainous headache) and people who were headache-free. RESULTS: The results showed in general small differences between headache sufferers and headache-free participants. In the cross-sectional analysis migraineurs without aura had fewer PVS than headache-free individuals in BG (OR = 0.84, 95% CI = 0.76--0.94, p value = 0.003) and in BG and HWM together (OR = 0.97, 95% CI = 0.95-1.00, p value = 0.046). No difference between long-term headache sufferers and long-term headache-free individuals with regard to number of PVS was found. DISCUSSION: In contrast to previous studies, the present large, blinded, population-based study showed no increase in number of dilated PVS among headache sufferers. Fewer PVS among those with migraine without aura may be a spurious finding.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian National Headache Centre, St Olavs University Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26024925 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1699  
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Author (up) Husoy, A.K.; Indergaard, M.K.; Honningsvag, L.M.; Haberg, A.K.; Hagen, K.; Linde, M.; Garseth, M.; Stovner, L.J. url  doi
  Title Perivascular spaces and headache: A population-based imaging study (HUNT-MRI) Type Journal Article
  Year 2016 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume 36 Issue 3 Pages 232-239  
  Keywords HUNT1; HUNT2; HUNT3; Virchow-Robin spaces; epidemiology; headache; magnetic resonance imaging; migraine; population-based  
  Abstract BACKGROUND: In four previous clinic-based MRI studies headache sufferers (in particular migraineurs) had more perivascular spaces (PVS) than individuals who were headache-free. METHODS: The present study was part of a large longitudinal, epidemiological study (Nord-Trondelag Health Survey (HUNT)). The 1006 participants, age 50-65 years at inclusion, had participated in all previous HUNT surveys (1-3), and been randomly selected to a population-based imaging study of the head (HUNT-MRI, 2007-2009). The number of visible PVS in the basal ganglia (BG) and hemispheric white matter (HWM) was compared in headache sufferers (migraine with and without aura, non-migrainous headache) and people who were headache-free. RESULTS: The results showed in general small differences between headache sufferers and headache-free participants. In the cross-sectional analysis migraineurs without aura had fewer PVS than headache-free individuals in BG (OR = 0.84, 95% CI = 0.76--0.94, p value = 0.003) and in BG and HWM together (OR = 0.97, 95% CI = 0.95-1.00, p value = 0.046). No difference between long-term headache sufferers and long-term headache-free individuals with regard to number of PVS was found. DISCUSSION: In contrast to previous studies, the present large, blinded, population-based study showed no increase in number of dilated PVS among headache sufferers. Fewer PVS among those with migraine without aura may be a spurious finding.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Norway ahusoy@gmail.com. Editor  
  Language Summary Language Original Title  
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  ISSN ISBN Medium  
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  Notes Husoy, Andreas KattemIndergaard, Marit KristinaHonningsvag, Lasse-MariusHaberg, Asta KHagen, KnutLinde, MattiasGarseth, MariStovner, Lars JacobengResearch Support, Non-U.S. Gov'tEngland2015/05/31 06:00Cephalalgia. 2016 Mar;36(3):232-9. doi: 10.1177/0333102415587691. Epub 2015 May 29. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Husoy2016 Serial 1753  
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Author (up) Husoy, A.K.; Pintzka, C.; Eikenes, L.; Haberg, A.K.; Hagen, K.; Linde, M.; Stovner, L.J. url  doi
  Title Volume and shape of subcortical grey matter structures related to headache: A cross-sectional population-based imaging study in the Nord-Trondelag Health Study Type Journal Article
  Year 2018 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages 333102418780632  
  Keywords Hunt; Neuroimaging; Wmh; striatum; surface-based methods  
  Abstract Background The relationship between subcortical nuclei and headache is unclear. Most previous studies were conducted in small clinical migraine samples. In the present population-based MRI study, we hypothesized that headache sufferers exhibit reduced volume and deformation of the nucleus accumbens compared to non-sufferers. In addition, volume and deformation of the amygdala, caudate, hippocampus, pallidum, putamen and thalamus were examined. Methods In all, 1006 participants (50-66 years) from the third Nord-Trondelag Health Survey, were randomly selected to undergo a brain MRI at 1.5 T. Volume and shape of the subcortical nuclei from T1 weighted 3D scans were obtained in FreeSurfer and FSL. The association with questionnaire-based headache categories (migraine and tension-type headache included) was evaluated using analysis of covariance. Individuals not suffering from headache were used as controls. Age, sex, intracranial volume and Hospital Anxiety and Depression Scale were used as covariates. Results No effect of headache status on accumbens volume and shape was present. Exploratory analyses showed significant but small differences in volume of caudate and putamen and in putamen shape between those with non-migrainous headache and the controls. A post hoc analysis showed that caudate volume was strongly associated with white matter hyperintensities. Conclusion We did not confirm our hypothesis that headache sufferers have smaller volume and different shape of the accumbens compared to non-sufferers. No or only small differences in volume and shape of subcortical nuclei between headache sufferers and non-sufferers appear to exist in the general population.  
  Address 4 Norwegian Advisory Unit on Headache, St. Olav's University Hospital, Trondheim, Norway  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29848110 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2102  
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Author (up) Jacobsena, B.A.; Dyb, G.; Hagen, K.; Stovner, L.J.; Holmen, T.L.; Zwart, J.-A. url  doi
  Title The Nord-Trondelag Health Study shows increased prevalence of primary recurrent headaches among adolescents over a four-year period Type Journal Article
  Year 2018 Publication Scandinavian Journal of Pain Abbreviated Journal Scand J Pain  
  Volume 2 Issue 3 Pages 148-152  
  Keywords Adolescents; Epidemiology; Headache; Migraine; Prevalence; Tension-type headache  
  Abstract Objective Earlier epidemiological studies have shown that headaches are frequent among adolescents, especially girls. In particular, recurrent primary headache disorders such as migraine and tension-type headaches are common complaints in this age group. Headaches are increasingly being recognized as a significant health problem in adolescents and can lead to significant disabilities by affecting their lives, their school performance and their social lives. The aim of this study was to compare the prevalence of primary headaches among adolescents aged 16-20 years in Norway in two periods. Very few replicate studies have re-evaluated the prevalence of primary headaches in this age range and it is uncertain whether the prevalence is increasing. Methods Two cross-sectional, population-based studies were conducted in Norway from 1995 to 1997 (Young-HUNT 1) and from 1999 to 2001 (Young-HUNT 2). In Young-HUNT 1, 2594 adolescents in 2nd and 3rd grade in upper secondary school (aged 16-20 years) completed a comprehensive questionnaire including one question regarding headache during the last 12 months. In addition, 1730 of the students were interviewed about their headache complaints. In Young-HUNT 2, 2373 adolescents aged 16-20 years completed the same questionnaire and 1655 were interviewed in the same way as the earlier survey. The interviews were performed by trained nurses, and respondents were asked if they had experienced recurrent headache during the last year. If so, the headache was classified as migraine (MI), tensiontype headache (TTH) or non-classifiable headache (NCH). Headache frequency during the past year was recorded according to the following categories: Less than 1 day per month (less than monthly), 1-3 days per month (monthly), 1-5 days per week (weekly), or more than 5 days per week (daily). Results The participation rate was 88% in Young-HUNT 1 and 81% in Young-HUNT 2. The overall prevalence of having had headaches during the last 12 months did not change significantly (79.4% versus 77.5%; OR: 0.89, 95%CI: 0.79-1.02, p = 0.09), whereas the prevalence of recurrent headaches increased from 30.3% in Young-HUNT 1 to 35.4% in Young-HUNT 2 (OR: 1.26, 95%CI: 1.09-1.46, p = 0.002). The prevalence of tension-type headache changed significantly from 19.0% to 21.9% (OR: 1.20, 95%CI: 1.02-1.42, p = 0.03). Also the prevalence of migraine tended to increase (7.5% versus 8.7%, OR: 1.18, 95%CI: 0.92-1.52, p = 0.18). The overall frequency of recurrent headache changed towards more monthly and less weekly headache. Conclusions This is the first large-scale population-based study among adolescents in Norway assessing changes in the prevalence of primary headaches over a four-year period of time. The overall prevalence of recurrent headaches increased significantly from Young-HUNT 1 to Young-HUNT 2. An increase was seen in all types of recurrent headaches and was significant for tension-type headache. Implications Earlier follow-up studies have examined changes in prevalence of recurrent headaches in young age, but the results are diverging. Our findings support the impression that the prevalence of recurrent headache among adolescents is increasing, and underlines the need for prospective designed studies with emphasis on prognosis and etiological factors.  
  Address National Centre for Spinal Disorders, St. Olavs Hospital, Trondheim, Norway  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1877-8860 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29913741 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2114  
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Author (up) Larsen, J.S.; Skaug, E.A.; Wisloff, U.; Ellingsen, O.; Stovner, L.J.; Linde, M.; Hagen, K. url  doi
  Title Migraine and endothelial function: The HUNT3 Study Type Journal Article
  Year 2016 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords  
  Abstract BACKGROUND: Reduced endothelial function is associated with elevated risk of cardiovascular disease, but evidence on the association between migraine and endothelial function is conflicting. The aim of this population-based study was to examine the relationship between flow-mediated dilatation (FMD) and migraine with aura, migraine without aura and tension-type headache. METHODS: In the third Nord-Trondelag Healthy Study (HUNT3) FMD was measured by ultrasound during reactive hyperaemia of the brachial artery in a sample of 4739 healthy adult participants, 3929 of whom answered headache questions. The cross-sectional association between different headache diagnoses and FMD was evaluated by logistic regression, using a categorical approach. RESULTS: Mean FMD did not differ between the headache groups and headache-free controls. In multi-adjusted analyses, no consistent association was found between FMD quintiles and headache groups. CONCLUSIONS: There was no relationship between FMD and migraine or other headache diagnoses in this large cross-sectional study of otherwise healthy respondents including freedom from pulmonary and cardiovascular diseases.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Norway.K.G. Jebsen Cente Editor  
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  Notes Larsen, Joakim SchjolbergSkaug, Eli-AnneWisloff, UlrikEllingsen, OyvindStovner, Lars JacobLinde, MattiasHagen, KnutENG2016/02/13 06:00Cephalalgia. 2016 Feb 10. pii: 0333102416631961. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Larsen2016 Serial 1761  
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Author (up) Linde, M.; Langnes, H.A.; Hagen, K.; Bergh, K.; Stovner, L.J. url  doi
  Title No increase in headache after previous intracranial infections: a historical cohort study (HUNT) Type Journal Article
  Year 2012 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume 19 Issue 2 Pages 324-331  
  Keywords Adult; Aged; Central Nervous System Infections/*complications; Cohort Studies; Female; Headache/diagnosis/*epidemiology/*etiology; Health Surveys; Humans; Longitudinal Studies; Male; Middle Aged; Prevalence; Questionnaires  
  Abstract BACKGROUND AND PURPOSE: Despite the absence of robust scientific evidence, it is today generally accepted that the acute headache typical for intracranial infections can develop into permanent headache complaints. This widespread concept was explored in the first, large, longitudinal, population-based study. METHODS: Data on confirmed exposure to intracranial infections amongst all adult inhabitants in a geographical area during a 20-year period were assembled from hospital records. Surviving individuals were later invited to the third Nord-Trondelag Health Survey (HUNT 3), where 39,690 (42%) of 94,194 invited inhabitants aged >/=20 years responded to a validated headache questionnaire. Using logistic regression, the 1-year prevalence of headache and its subtypes according to the diagnostic criteria of the International Headache Society was assessed and compared between those with and without previous confirmed intracranial infection. Age and sex were used as covariates. RESULTS: Overall, 43 participants were identified with earlier intracranial infection, whereof three had more than one infection: bacterial meningitis (n=19), lymphocytic meningitis (n=18), encephalitis (n=9), and brain abscess (n=1).The mean interval from infection to participation in HUNT 3 was 11.2 (range 1.5-19.7) years. There was no significant increase in the prevalence of headache (OR 1.10, 95% CI 0.58-2.07), its subtypes (migraine, or tension-type headache), or chronic daily headache (OR 1.85, 95% CI 0.45-7.68) amongst participants with previous intracranial infection compared with the surrounding population. CONCLUSIONS: This study challenges the existence of chronic post-bacterial meningitis headache and does not indicate the presence of other long-term headaches induced by intracranial infection.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. mattias.linde@ntnu.no  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
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  Notes PMID:21951375 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1545  
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Author (up) Nordhaug, L.H.; Hagen, K.; Vik, A.; Stovner, L.J.; Follestad, T.; Pedersen, T.; Gravdahl, G.B.; Linde, M. url  doi
  Title Headache following head injury: a population-based longitudinal cohort study (HUNT) Type Journal Article
  Year 2018 Publication The Journal of Headache and Pain Abbreviated Journal J Headache Pain  
  Volume 19 Issue 1 Pages 8  
  Keywords Adult; Aged; Cohort Studies; Craniocerebral Trauma/*diagnosis/*epidemiology/psychology; Female; Headache/*diagnosis/*epidemiology/psychology; Health Surveys/*trends; Humans; Longitudinal Studies; Male; Middle Aged; *Population Surveillance; Head injury; Headache attributed to head injury;