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Author Grov, E.K.; Fossa, S.D.; Dahl, A.A. url  doi
  Title A controlled study of the influence of comorbidity on activities of daily living in elderly cancer survivors (the HUNT-3 survey) Type Journal Article
  Year 2017 Publication Journal of Geriatric Oncology Abbreviated Journal J Geriatr Oncol  
  Volume 8 Issue 5 Pages 328-335  
  Keywords Adl; Activities of daily living; Cancer survivors; Comorbidity; Elderly; Home dwelling  
  Abstract OBJECTIVES: To examine the influence of somatic comorbidity on Activity of Daily Living (ADL) problems in cancer survivors >/=70years (ECSs) based on data from The Health Study of Nord-Trondelag County (HUNT-3) 2006-08. MATERIAL AND METHODS: Among participants of the HUNT-3 survey, 599 ECSs had a diagnosis of one invasive cancer according to both The Cancer Registry of Norway and self-report. Three controls without cancer aged >/=70years for each ECS were drawn from the HUNT-3 sample. We compared personal-ADL (P-ADL) and instrumental-ADL (I-ADL) problems for ECSs and differences between ADL problems for ECSs with and without comorbidity and controls with and without comorbidity. RESULTS: The prevalence of P-ADL problems was 3.5% among ECSs and 2.9% among controls (p=0.97) and for I-ADL 28.5% versus 21.4% (p=0.01), respectively. In bivariate analyses where ECSs versus controls was the dependent variable, presence of I-ADL problems, higher age, being female, paired relationship, poor self-rated health, hospitalization last year, and low level of neuroticism were associated being ECSs. In multivariate analyses, these variables, except I-ADL-problems and paired relationship, remained significantly associated being ECSs. No significant differences were shown for P-ADL problems when comparing ECSs and controls with comorbidity, and ECSs with and without comorbidity. ECSs with comorbidity reported significantly more I-ADL-problems than controls with comorbidity, and ECSs with comorbidity had significantly more I-ADL-problems than ECSs without comorbidity. CONCLUSION: Our results reflect common factors found in ADL studies in the elderly population. Health personnel have to be particularly observant on I-ADL problems among female ECSs, and those reporting poor self-rated health or comorbidity.  
  Address National Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital, Norwegian Radium Hospital, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, 0316 Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1879-4068 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28629695 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1917  
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Author Jeppesen, E.; Bjelland, I.; Fossa, S.D.; Loge, J.H.; Sorebo, O.; Dahl, A.A. url  doi
  Title Does a parental history of cancer moderate the associations between impaired health status in parents and psychosocial problems in teenagers: a HUNT study Type Journal Article
  Year 2014 Publication Cancer Medicine Abbreviated Journal Cancer Med  
  Volume Issue Pages  
  Keywords HUNT-2; parental cancer; psychosocial problems; teenagers; young-HUNT  
  Abstract Severe disease in a parent is associated with increased psychosocial problems in their children. However, moderating factors of such associations are less studied. In this cross-sectional population-based controlled study we examined the moderating effects of a history of parental cancer on the association between impaired health status in parents and psychosocial problems among their teenagers. Among families with both parents responding to the adult Health Survey of Nord-Trondelag County of Norway (the HUNT-2 study) 71 couples were identified with primary invasive cancer in one parent. Their 81 teenage children took part in the Young-HUNT study. These families were compared to 322 cancer-free families with 328 teenagers. Based on self-report data the relations between three variables of parental impaired health and six psychosocial problems in teenagers were analyzed family wise by structural equation modeling. Significant associations between parental and teenagers' variables were observed in eight of 18 models. A history of parental cancer was a significant moderator which decreased four of eight significant associations. Such a history significantly weakened the associations between parental poor self-rated health and teenagers' anxiety/depression and school problems. A similar association of a history of parental cancer was found between psychological distress in parents and teenagers' feelings of loneliness and poor self-rated health. This study confirmed strong associations between impaired parental health and psychosocial problems in their teenagers. A history of parental cancer weakened several of the significant associations between parental impaired health variables and psychosocial problems in their teenagers.  
  Address National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway; University of Oslo, Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-7634 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24723456 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1594  
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Author Markaki, M.; Tsamardinos, I.; Langhammer, A.; Lagani, V.; Hveem, K.; Roe, O.D. url  doi
  Title A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study Type Journal Article
  Year 2018 Publication EBioMedicine Abbreviated Journal EBioMedicine  
  Volume 31 Issue Pages 36-46  
  Keywords Adult; Aged; Aged, 80 and over; Databases, Factual; Female; Follow-Up Studies; Humans; Lung Neoplasms/*epidemiology; Male; Middle Aged; *Models, Biological; Norway; Predictive Value of Tests; Prospective Studies; *Registries; Risk Factors; *Smoking/adverse effects/epidemiology; All ages; All smokers; Data-driven; Early diagnosis; Ever-smokers; External validation; Feature selection; Lung cancer prediction  
  Abstract Lung cancer causes >1.6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population study in Norway examined 65,237 people aged >20years in 1995-97. After a median of 15.2years, 583 lung cancer cases had been diagnosed; 552 (94.7%) ever-smokers and 31 (5.3%) never-smokers. We performed multivariable analyses of 36 candidate risk predictors, using multiple imputation of missing data and backwards feature selection with Cox regression. The resulting model was validated in an independent Norwegian prospective dataset of 45,341 ever-smokers, in which 675 lung cancers had been diagnosed after a median follow-up of 11.6years. Our final HUNT Lung Cancer Model included age, pack-years, smoking intensity, years since smoking cessation, body mass index, daily cough, and hours of daily indoors exposure to smoke. External validation showed a 0.879 concordance index (95% CI [0.866-0.891]) with an area under the curve of 0.87 (95% CI [0.85-0.89]) within 6years. Only 22% of ever-smokers would need screening to identify 81.85% of all lung cancers within 6years. Our model of seven variables is simple, accurate, and useful for screening selection.  
  Address Norwegian University of Science and Technology, Department of Clinical Research and Molecular Medicine, Prinsesse Kristinsgt. 1, Trondheim, NO 7491, Norway; Levanger Hospital, Nord-Trondelag Hospital Trust, Cancer Clinic, Kirkegata 2, Levanger, NO 7600, Norway; Clinical Cancer Research Center, Department of Clinical Medicine, Hobrovej 18-22, Aalborg, DK 9000, Denmark. Electronic address: oluf.roe@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2352-3964 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29678673; PMCID:PMC6013755 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2131  
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Author Moe, B.; Nilsen, T.I.   
  Title Cancer risk in people with diabetes: Does physical activity and adiposity modify the association? Prospective data from the HUNT Study, Norway Type Journal Article
  Year 2015 Publication J Diabetes Complications Abbreviated Journal Journal of diabetes and its complications  
  Volume 29 Issue 2 Pages 176-179  
  Keywords *Adiposity; Adult; Aged; Aged, 80 and over; Body Mass Index; Cohort Studies; Diabetes Complications/epidemiology/*etiology/prevention & control; Female; Follow-Up Studies; Health Surveys; Humans; Incidence; Male; Middle Aged; Motor Activity; Neoplasms/complications/epidemiology/*etiology/prevention & control; Norway/epidemiology; Obesity/*physiopathology; Overweight/*physiopathology; Prevalence; Proportional Hazards Models; Prospective Studies; Risk; *Sedentary Lifestyle; Young Adult; Cancer risk; Diabetes; Epidemiology; Leisure time physical exercise  
  Abstract AIMS: To examine whether physical activity and adiposity modify the increased risk of cancer associated with diabetes. METHODS: We prospectively examined the association of diabetes and risk of cancer among 73,726 persons stratified by physical activity and body mass index (BMI). Adjusted hazard ratios (HRs) with 95% confidence intervals (CI) were estimated from Cox regression. RESULTS: During a median follow-up of 22.0 years, 9572 people were diagnosed with incident cancer. There was no clear association between diabetes and cancer risk in those reporting high levels of physical activity (>/=2.0h per week) (HR 0.93; 95% CI: 0.70-1.24) or those with a normal weight (BMI  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Public Health and General Practice, Norwegian University of Science and Technology, Tr Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Moe2015b Serial 1847  
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Author Moe, B.; Nilsen, T.I.L. url  doi
  Title Cancer risk in people with diabetes: does physical activity and adiposity modify the association? Prospective data from the HUNT Study, Norway Type Journal Article
  Year 2014 Publication Journal of Diabetes and its Complications Abbreviated Journal J Diabetes Complications  
  Volume Issue Pages  
  Keywords Body mass index; Cancer risk; Diabetes; Epidemiology; Leisure time physical exercise; HUNT1  
  Abstract AIMS: To examine whether physical activity and adiposity modify the increased risk of cancer associated with diabetes. METHODS: We prospectively examined the association of diabetes and risk of cancer among 73,726 persons stratified by physical activity and body mass index (BMI). Adjusted hazard ratios (HRs) with 95% confidence intervals (CI) were estimated from Cox regression. RESULTS: During a median follow-up of 22.0years, 9572 people were diagnosed with incident cancer. There was no clear association between diabetes and cancer risk in those reporting high levels of physical activity (>/=2.0h per week) (HR 0.93; 95% CI: 0.70-1.24) or those with a normal weight (BMI <25kg/m2) (HR 1.02; 95% CI: 0.84-1.25). However, among people with diabetes who reported low levels of physical activity (<2.0h per week), diabetes was associated with an HR of 1.15 (95% CI: 1.01-1.31). Correspondingly, diabetes was associated with an HR of 1.21 (95% CI: 1.07-1.37) among overweight or obese people (BMI >/=25kg/m2). CONCLUSIONS: There was evidence that the increased risk of cancer associated with diabetes was confined to persons who reported low levels of physical activity, or who were overweight or obese.  
  Address Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1056-8727 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25534878 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1659  
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Author Ness-Jensen, E.; Gottlieb-Vedi, E.; Wahlin, K.; Lagergren, J. url  doi
  Title All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study) Type Journal Article
  Year 2018 Publication Gut Abbreviated Journal  
  Volume 67 Issue 2 Pages 209-215  
  Keywords Adenocarcinoma/*mortality; Adult; Aged; Aged, 80 and over; Cause of Death; Esophageal Neoplasms/*mortality; Female; Gastroesophageal Reflux/epidemiology/*mortality; Head and Neck Neoplasms/mortality; Humans; Lung Neoplasms/*mortality; Male; Middle Aged; Norway/epidemiology; Severity of Illness Index; Sex Factors; Young Adult; *acid-related diseases; *adenocarcinoma; *cancer; *epidemiology; *gastroesophageal reflux disease  
  Abstract OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of this study was to test the hypothesis that reflux increases all-cause and cancer-specific mortalities in an unselected cohort. DESIGN: The Nord-Trondelag health study (HUNT), a Norwegian population-based cohort study, was used to identify individuals with and without reflux in 1995-1997 and 2006-2008, with follow-up until 2014. All-cause mortality and cancer-specific mortality were assessed from the Norwegian Cause of Death Registry and Cancer Registry. Multivariable Cox regression was used to calculate HRs with 95% CIs for mortality with adjustments for potential confounders. RESULTS: We included 4758 participants with severe reflux symptoms and 51 381 participants without reflux symptoms, contributing 60 323 and 747 239 person-years at risk, respectively. Severe reflux was not associated with all-cause mortality, overall cancer-specific mortality or mortality in cancer of the head-and-neck or lung. However, for men with severe reflux a sixfold increase in oesophageal adenocarcinoma-specific mortality was found (HR 6.09, 95% CI 2.33 to 15.93) and the mortality rate was 0.27 per 1000 person-years. For women, the corresponding mortality was not significantly increased (HR 3.68, 95% CI 0.88 to 15.27) and the mortality rate was 0.05 per 1000 person-years. CONCLUSIONS: Individuals with severe reflux symptoms do not seem to have increased all-cause mortality or overall cancer-specific mortality. Although the absolute risk is small, individuals with severe reflux symptoms have a clearly increased oesophageal adenocarcinoma-specific mortality.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Upper Gastrointestinal Surgery, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.HUNT Research Centre, Department of Public Health and General Practice, NTNU, Norwegian University of Science and Technology, Levanger, Norway.Medical Department, Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway.Division of Cancer Studies, King's College London, London, UK. Editor  
  Language Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Ness-Jensen, EivindGottlieb-Vedi, EivindWahlin, KarlLagergren, JesperengResearch Support, Non-U.S. Gov'tEnglandGut. 2018 Feb;67(2):209-215. doi: 10.1136/gutjnl-2016-312514. Epub 2016 Oct 27. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Ness-Jensen2018 Serial 2065  
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Author Ness-Jensen, E.; Gottlieb-Vedi, E.; Wahlin, K.; Lagergren, J. url  doi
  Title All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study) Type Journal Article
  Year 2018 Publication Gut Abbreviated Journal Gut  
  Volume 67 Issue 2 Pages 209-215  
  Keywords Adenocarcinoma/*mortality; Adult; Aged; Aged, 80 and over; Cause of Death; Esophageal Neoplasms/*mortality; Female; Gastroesophageal Reflux/epidemiology/*mortality; Head and Neck Neoplasms/mortality; Humans; Lung Neoplasms/*mortality; Male; Middle Aged; Norway/epidemiology; Severity of Illness Index; Sex Factors; Young Adult; *Acid-Related Diseases; *Adenocarcinoma; *Cancer; *Epidemiology; *Gastroesophageal Reflux Disease  
  Abstract OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of this study was to test the hypothesis that reflux increases all-cause and cancer-specific mortalities in an unselected cohort. DESIGN: The Nord-Trondelag health study (HUNT), a Norwegian population-based cohort study, was used to identify individuals with and without reflux in 1995-1997 and 2006-2008, with follow-up until 2014. All-cause mortality and cancer-specific mortality were assessed from the Norwegian Cause of Death Registry and Cancer Registry. Multivariable Cox regression was used to calculate HRs with 95% CIs for mortality with adjustments for potential confounders. RESULTS: We included 4758 participants with severe reflux symptoms and 51 381 participants without reflux symptoms, contributing 60 323 and 747 239 person-years at risk, respectively. Severe reflux was not associated with all-cause mortality, overall cancer-specific mortality or mortality in cancer of the head-and-neck or lung. However, for men with severe reflux a sixfold increase in oesophageal adenocarcinoma-specific mortality was found (HR 6.09, 95% CI 2.33 to 15.93) and the mortality rate was 0.27 per 1000 person-years. For women, the corresponding mortality was not significantly increased (HR 3.68, 95% CI 0.88 to 15.27) and the mortality rate was 0.05 per 1000 person-years. CONCLUSIONS: Individuals with severe reflux symptoms do not seem to have increased all-cause mortality or overall cancer-specific mortality. Although the absolute risk is small, individuals with severe reflux symptoms have a clearly increased oesophageal adenocarcinoma-specific mortality.  
  Address Division of Cancer Studies, King's College London, London, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0017-5749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27789657 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2142  
Permanent link to this record
 

 
Author Perreault, K.; Bauman, A.; Johnson, N.; Britton, A.; Rangul, V.; Stamatakis, E. url  doi
  Title Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality? A pooled analysis of eight British population cohorts Type Journal Article
  Year 2017 Publication British Journal of Sports Medicine Abbreviated Journal Br J Sports Med  
  Volume 51 Issue 8 Pages 651-657  
  Keywords Adult; Aged; Aged, 80 and over; Alcohol Drinking/*adverse effects; Cardiovascular Diseases/*mortality; England; *Exercise; Female; Health Surveys; Humans; Male; Middle Aged; Mortality; Neoplasms/*mortality; Proportional Hazards Models; Prospective Studies; Risk Factors; Cancer; Epidemiology; Physical activity; Public health  
  Abstract OBJECTIVE: To examine whether physical activity (PA) moderates the association between alcohol intake and all-cause mortality, cancer mortality and cardiovascular diseases (CVDs) mortality. DESIGN: Prospective study using 8 British population-based surveys, each linked to cause-specific mortality: Health Survey for England (1994, 1998, 1999, 2003, 2004 and 2006) and Scottish Health Survey (1998 and 2003). PARTICIPANTS: 36 370 men and women aged 40 years and over were included with a corresponding 5735 deaths and a mean of 353 049 person-years of follow-up. EXPOSURES: 6 sex-specific categories of alcohol intake (UK units/week) were defined: (1) never drunk; (2) ex-drinkers; (3) occasional drinkers; (4) within guidelines (<14 (women); <21 (men)); (5) hazardous (14-35 (women); 21-49 (men)) and (6) harmful (>35 (women) >49 (men)). PA was categorised as inactive (</=7 MET-hour/week), active at the lower (>7.5 MET-hour/week) and upper (>15 MET-hour/week) of recommended levels. MAIN OUTCOMES AND MEASURES: Cox proportional-hazard models were used to examine associations between alcohol consumption and all-cause, cancer and CVD mortality risk after adjusting for several confounders. Stratified analyses were performed to evaluate mortality risks within each PA stratum. RESULTS: We found a direct association between alcohol consumption and cancer mortality risk starting from drinking within guidelines (HR (95% CI) hazardous drinking: 1.40 (1.11 to 1.78)). Stratified analyses showed that the association between alcohol intake and mortality risk was attenuated (all-cause) or nearly nullified (cancer) among individuals who met the PA recommendations (HR (95% CI)). CONCLUSIONS: Meeting the current PA public health recommendations offsets some of the cancer and all-cause mortality risk associated with alcohol drinking.  
  Address Department of Epidemiology and Public Health, University College London, London, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-3674 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27581162 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1970  
Permanent link to this record
 

 
Author Sorli, K.; Thorvaldsen, S.M.; Hatlen, P. url  doi
  Title Use of Inhaled Corticosteroids and the Risk of Lung Cancer, the HUNT Study Type Journal Article
  Year 2018 Publication Lung Abbreviated Journal Lung  
  Volume 196 Issue 2 Pages 179-184  
  Keywords *Copd; *Ics; *Lung cancer  
  Abstract BACKGROUND: Inflammation plays a central role in chronic obstructive pulmonary disease and lung cancer carcinogenesis. Inhaled corticosteroids (ICS) reduce inflammation. This study has investigated whether ICS use is associated with a lower risk of lung cancer. MATERIALS AND METHODS: Data from the Nord-Trondelag Health Study (HUNT2 Survey, 1995-1997) were merged with The Cancer Registry of Norway and Norwegian Cause of Death Registry. From a total of 65,215 participants, those with chronic airway inflammation, defined by FEV1% < 70 and/or chronic cough and expectorate phlegm, were included (N = 4136). Of these, 3041 individuals reported regarding ICS use and were observed for a period of 12 years. Cox regression models were used to calculate the risk of lung cancer with a 95% confidence interval (CI) with sex, age, smoking pack years and FEV1% < 70 as known confounders. RESULTS: Among ICS users (N = 1095). we found a higher, but not significant, incidence of lung cancer N = 39 (3.6%), compared to non-users (N = 1946) with N = 65 (3.3%) cases. Age and smoking were associated with a higher risk, while sex and lung function were not. After adjusting for confounders, ICS use did not change the risk of lung cancer, hazard ratio (HR) 0.968, (95% CI, 0.608-1.540), and p value 0.890. CONCLUSION: ICS use is not associated with a reduced risk of lung cancer in our study population.  
  Address Department of Circulation and Medical Imaging (ISB), Faculty of Medicine and Health Sciences, NTNU, 7489, Trondheim, Norway. peter.hatlen@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0341-2040 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29427221 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2159  
Permanent link to this record
 

 
Author Sorli, K.; Thorvaldsen, S.M.; Hatlen, P. url  doi
  Title Use of Inhaled Corticosteroids and the Risk of Lung Cancer, the HUNT Study Type Journal Article
  Year 2018 Publication Lung Abbreviated Journal Lung  
  Volume 196 Issue 2 Pages 179-184  
  Keywords *Copd; *Ics; *Lung cancer  
  Abstract BACKGROUND: Inflammation plays a central role in chronic obstructive pulmonary disease and lung cancer carcinogenesis. Inhaled corticosteroids (ICS) reduce inflammation. This study has investigated whether ICS use is associated with a lower risk of lung cancer. MATERIALS AND METHODS: Data from the Nord-Trondelag Health Study (HUNT2 Survey, 1995-1997) were merged with The Cancer Registry of Norway and Norwegian Cause of Death Registry. From a total of 65,215 participants, those with chronic airway inflammation, defined by FEV1% < 70 and/or chronic cough and expectorate phlegm, were included (N = 4136). Of these, 3041 individuals reported regarding ICS use and were observed for a period of 12 years. Cox regression models were used to calculate the risk of lung cancer with a 95% confidence interval (CI) with sex, age, smoking pack years and FEV1% < 70 as known confounders. RESULTS: Among ICS users (N = 1095). we found a higher, but not significant, incidence of lung cancer N = 39 (3.6%), compared to non-users (N = 1946) with N = 65 (3.3%) cases. Age and smoking were associated with a higher risk, while sex and lung function were not. After adjusting for confounders, ICS use did not change the risk of lung cancer, hazard ratio (HR) 0.968, (95% CI, 0.608-1.540), and p value 0.890. CONCLUSION: ICS use is not associated with a reduced risk of lung cancer in our study population.  
  Address Department of Circulation and Medical Imaging (ISB), Faculty of Medicine and Health Sciences, NTNU, 7489, Trondheim, Norway. peter.hatlen@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0341-2040 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29427221 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2171  
Permanent link to this record
 

 
Author Sun, Y.-Q.; Langhammer, A.; Wu, C.; Skorpen, F.; Chen, Y.; Nilsen, T.I.L.; Romundstad, P.R.; Mai, X.-M. url  doi
  Title Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study Type Journal Article
  Year 2017 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol  
  Volume Issue Pages  
  Keywords Case-cohort study; Histologic types; Lung cancer; Pulmonary adenocarcinoma; Serum 25-hydroxyvitamin D [25(OH)D]; Vitamin D  
  Abstract Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of serum 25(OH)D levels with incidence of lung cancer overall and different histologic types. We performed a population-based prospective case-cohort study including 696 incident lung cancer cases and 5804 individuals in a subcohort who participated in the second survey of the Nord-Trondelag Health Study in Norway. Cox proportional hazards regression models counting for the case-cohort design were used to estimate hazard ratios (HRs) with 95% confidence interval (CIs) for lung cancer overall or histologic types in relation to serum 25(OH)D levels. Compared with the fourth season-specific quartile of 25(OH)D (median 68.0 nmol/L), lower 25(OH)D levels were not associated with the incidence of overall, small or squamous cell lung cancer. However, the risk of adenocarcinoma was lower in the second and third quartiles (median 39.9 and 51.5 nmol/L) compared with the fourth quartile, with HRs of 0.63 (95% CI 0.41-0.98) and 0.58 (0.38-0.88), respectively. The associations of lower levels of 25(OH)D with a reduced risk of adenocarcinoma were only observed in the overweight/obese subjects [HRs for second and third quartiles: 0.40 (0.22-0.72) and 0.50 (0.27-0.92)] but not in the normal weight subjects [HRs: 0.95 (0.52-1.75) and 0.60 (0.32-1.10)]. Serum 25(OH)D levels were not associated with the risk of lung cancer in general. The observation that lower 25(OH)D levels were associated with a lower risk of adenocarcinoma should be interpreted with caution.  
  Address Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0393-2990 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29080012 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2007  
Permanent link to this record
 

 
Author Sun, Y.-Q.; Langhammer, A.; Wu, C.; Skorpen, F.; Chen, Y.; Nilsen, T.I.L.; Romundstad, P.R.; Mai, X.-M. url  doi
  Title Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study Type Journal Article
  Year 2018 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol  
  Volume 33 Issue 1 Pages 67-77  
  Keywords Adenocarcinoma/blood/*epidemiology/pathology; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Incidence; Lung Neoplasms/blood/*epidemiology/pathology; Male; Middle Aged; Norway/epidemiology; Prospective Studies; Vitamin D/*analogs & derivatives/blood; *Case-cohort study; *Histologic types; *Lung cancer; *Pulmonary adenocarcinoma; *Serum 25-hydroxyvitamin D [25(OH)D]; *Vitamin D  
  Abstract Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of serum 25(OH)D levels with incidence of lung cancer overall and different histologic types. We performed a population-based prospective case-cohort study including 696 incident lung cancer cases and 5804 individuals in a subcohort who participated in the second survey of the Nord-Trondelag Health Study in Norway. Cox proportional hazards regression models counting for the case-cohort design were used to estimate hazard ratios (HRs) with 95% confidence interval (CIs) for lung cancer overall or histologic types in relation to serum 25(OH)D levels. Compared with the fourth season-specific quartile of 25(OH)D (median 68.0 nmol/L), lower 25(OH)D levels were not associated with the incidence of overall, small or squamous cell lung cancer. However, the risk of adenocarcinoma was lower in the second and third quartiles (median 39.9 and 51.5 nmol/L) compared with the fourth quartile, with HRs of 0.63 (95% CI 0.41-0.98) and 0.58 (0.38-0.88), respectively. The associations of lower levels of 25(OH)D with a reduced risk of adenocarcinoma were only observed in the overweight/obese subjects [HRs for second and third quartiles: 0.40 (0.22-0.72) and 0.50 (0.27-0.92)] but not in the normal weight subjects [HRs: 0.95 (0.52-1.75) and 0.60 (0.32-1.10)]. Serum 25(OH)D levels were not associated with the risk of lung cancer in general. The observation that lower 25(OH)D levels were associated with a lower risk of adenocarcinoma should be interpreted with caution.  
  Address Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0393-2990 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29080012 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2178  
Permanent link to this record
 

 
Author Tanskanen, T.; van den Berg, L.; Valimaki, N.; Aavikko, M.; Ness-Jensen, E.; Hveem, K.; Wettergren, Y.; Bexe Lindskog, E.; Tonisson, N.; Metspalu, A.; Silander, K.; Orlando, G.; Law, P.J.; Tuupanen, S.; Gylfe, A.E.; Hanninen, U.A.; Cajuso, T.; Kondelin, J.; Sarin, A.-P.; Pukkala, E.; Jousilahti, P.; Salomaa, V.; Ripatti, S.; Palotie, A.; Jarvinen, H.; Renkonen-Sinisalo, L.; Lepisto, A.; Bohm, J.; Mecklin, J.-P.; Al-Tassan, N.A.; Palles, C.; Martin, L.; Barclay, E.; Tenesa, A.; Farrington, S.M.; Timofeeva, M.N.; Meyer, B.F.; Wakil, S.M.; Campbell, H.; Smith, C.G.; Idziaszczyk, S.; Maughan, T.S.; Kaplan, R.; Kerr, R.; Kerr, D.; Buchanan, D.D.; Win, A.K.; Hopper, J.; Jenkins, M.A.; Newcomb, P.A.; Gallinger, S.; Conti, D.; Schumacher, F.R.; Casey, G.; Cheadle, J.P.; Dunlop, M.G.; Tomlinson, I.P.; Houlston, R.S.; Palin, K.; Aaltonen, L.A. url  doi
  Title Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci Type Meta-Analysis
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 3 Pages 540-546  
  Keywords Case-Control Studies; Cohort Studies; Colorectal Neoplasms/*epidemiology/*genetics; Estonia/epidemiology; Finland/epidemiology; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Registries; colorectal cancer; genetic predisposition to disease; genome-wide association study; single-nucleotide polymorphism  
  Abstract Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 x 10(-4) ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 x 10(-9) ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.  
  Address Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28960316 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1993  
Permanent link to this record
 

 
Author Tanskanen, T.; van den Berg, L.; Valimaki, N.; Aavikko, M.; Ness-Jensen, E.; Hveem, K.; Wettergren, Y.; Bexe Lindskog, E.; Tonisson, N.; Metspalu, A.; Silander, K.; Orlando, G.; Law, P.J.; Tuupanen, S.; Gylfe, A.E.; Hanninen, U.A.; Cajuso, T.; Kondelin, J.; Sarin, A.-P.; Pukkala, E.; Jousilahti, P.; Salomaa, V.; Ripatti, S.; Palotie, A.; Jarvinen, H.; Renkonen-Sinisalo, L.; Lepisto, A.; Bohm, J.; Mecklin, J.-P.; Al-Tassan, N.A.; Palles, C.; Martin, L.; Barclay, E.; Tenesa, A.; Farrington, S.M.; Timofeeva, M.N.; Meyer, B.F.; Wakil, S.M.; Campbell, H.; Smith, C.G.; Idziaszczyk, S.; Maughan, T.S.; Kaplan, R.; Kerr, R.; Kerr, D.; Buchanan, D.D.; Win, A.K.; Hopper, J.; Jenkins, M.A.; Newcomb, P.A.; Gallinger, S.; Conti, D.; Schumacher, F.R.; Casey, G.; Cheadle, J.P.; Dunlop, M.G.; Tomlinson, I.P.; Houlston, R.S.; Palin, K.; Aaltonen, L.A. url  doi
  Title Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci Type Journal Article
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 3 Pages 540-546  
  Keywords Case-Control Studies; Cohort Studies; Colorectal Neoplasms/*epidemiology/*genetics; Estonia/epidemiology; Finland/epidemiology; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Registries; *colorectal cancer; *genetic predisposition to disease; *genome-wide association study; *single-nucleotide polymorphism  
  Abstract Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 x 10(-4) ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 x 10(-9) ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.  
  Address Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28960316 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2180  
Permanent link to this record
 

 
Author Theofylaktopoulou, D.; Midttun, O.; Ueland, P.M.; Meyer, K.; Fanidi, A.; Zheng, W.; Shu, X.-O.; Xiang, Y.-B.; Prentice, R.; Pettinger, M.; Thomson, C.A.; Giles, G.G.; Hodge, A.; Cai, Q.; Blot, W.J.; Wu, J.; Johansson, M.; Hultdin, J.; Grankvist, K.; Stevens, V.L.; McCullough, M.M.; Weinstein, S.J.; Albanes, D.; Ziegler, R.; Freedman, N.D.; Langhammer, A.; Hveem, K.; Naess, M.; Sesso, H.D.; Gaziano, J.M.; Buring, J.E.; Lee, I.-M.; Severi, G.; Zhang, X.; Stampfer, M.J.; Han, J.; Smith-Warner, S.A.; Zeleniuch-Jacquotte, A.; Le Marchand, L.; Yuan, J.-M.; Wang, R.; Butler, L.M.; Koh, W.-P.; Gao, Y.-T.; Rothman, N.; Ericson, U.; Sonestedt, E.; Visvanathan, K.; Jones, M.R.; Relton, C.; Brennan, P.; Johansson, M.; Ulvik, A. url  doi
  Title Impaired functional vitamin B6 status is associated with increased risk of lung cancer Type Journal Article
  Year 2017 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume Issue Pages  
  Keywords 3-hydroxykynurenine:xanthurenic acid; Lung Cancer Cohort Consortium; functional vitamin B6 marker; pyridoxal 5'-phosphate  
  Abstract Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR4thvs.1st ) was 1.25 (95% confidence interval, 1.10-1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.  
  Address Bevital AS, Bergen, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29238985 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2011  
Permanent link to this record
 

 
Author Theofylaktopoulou, D.; Midttun, O.; Ueland, P.M.; Meyer, K.; Fanidi, A.; Zheng, W.; Shu, X.-O.; Xiang, Y.-B.; Prentice, R.; Pettinger, M.; Thomson, C.A.; Giles, G.G.; Hodge, A.; Cai, Q.; Blot, W.J.; Wu, J.; Johansson, M.; Hultdin, J.; Grankvist, K.; Stevens, V.L.; McCullough, M.M.; Weinstein, S.J.; Albanes, D.; Ziegler, R.; Freedman, N.D.; Langhammer, A.; Hveem, K.; Naess, M.; Sesso, H.D.; Gaziano, J.M.; Buring, J.E.; Lee, I.-M.; Severi, G.; Zhang, X.; Stampfer, M.J.; Han, J.; Smith-Warner, S.A.; Zeleniuch-Jacquotte, A.; Le Marchand, L.; Yuan, J.-M.; Wang, R.; Butler, L.M.; Koh, W.-P.; Gao, Y.-T.; Rothman, N.; Ericson, U.; Sonestedt, E.; Visvanathan, K.; Jones, M.R.; Relton, C.; Brennan, P.; Johansson, M.; Ulvik, A. url  doi
  Title Impaired functional vitamin B6 status is associated with increased risk of lung cancer Type Journal Article
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 12 Pages 2425-2434  
  Keywords Aged; Biomarkers/blood; Carcinoma, Squamous Cell/*blood/*pathology; Case-Control Studies; Cohort Studies; Female; Humans; Lung Neoplasms/*blood/*pathology; Male; Middle Aged; Odds Ratio; Risk Factors; Vitamin B 6/*blood; *3-hydroxykynurenine:xanthurenic acid; *Lung Cancer Cohort Consortium; *functional vitamin B6 marker; *pyridoxal 5'-phosphate  
  Abstract Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR4thvs.1st ) was 1.25 (95% confidence interval, 1.10-1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.  
  Address Bevital AS, Bergen, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29238985; PMCID:PMC5908731 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2182  
Permanent link to this record
 

 
Author van Duijnhoven, F.J.B.; Jenab, M.; Hveem, K.; Siersema, P.D.; Fedirko, V.; Duell, E.J.; Kampman, E.; Halfweeg, A.; van Kranen, H.J.; van den Ouweland, J.M.W.; Weiderpass, E.; Murphy, N.; Langhammer, A.; Ness-Jensen, E.; Olsen, A.; Tjonneland, A.; Overvad, K.; Cadeau, C.; Kvaskoff, M.; Boutron-Ruault, M.-C.; Katzke, V.A.; Kuhn, T.; Boeing, H.; Trichopoulou, A.; Kotanidou, A.; Kritikou, M.; Palli, D.; Agnoli, C.; Tumino, R.; Panico, S.; Matullo, G.; Peeters, P.; Brustad, M.; Olsen, K.S.; Lasheras, C.; Obon-Santacana, M.; Sanchez, M.-J.; Dorronsoro, M.; Chirlaque, M.-D.; Barricarte, A.; Manjer, J.; Almquist, M.; Renstrom, F.; Ye, W.; Wareham, N.; Khaw, K.-T.; Bradbury, K.E.; Freisling, H.; Aune, D.; Norat, T.; Riboli, E.; Bueno-de-Mesquita, H.B.A. url  doi
  Title Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations Type Journal Article
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 6 Pages 1189-1201  
  Keywords 25-Hydroxyvitamin D 2/*blood; Aged; Calcifediol/*blood; Case-Control Studies; Europe; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Pancreatic Neoplasms/blood/*epidemiology; Prospective Studies; Risk Assessment; Seasons; *cancer epidemiology; *nested case-control study; *pancreatic cancer; *vitamin D  
  Abstract Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trondelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of </=25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.  
  Address Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29114875; PMCID:PMC5813219 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2186  
Permanent link to this record
 

 
Author Wiedmann, M.; Brunborg, C.; Lindemann, K.; Johannesen, T.B.; Vatten, L.; Helseth, E.; Zwart, J.A. url  doi
  Title Smoking, obesity and the risk of pituitary adenoma: a large prospective cohort study (The HUNT Study) Type Journal Article
  Year 2015 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol  
  Volume Issue Pages  
  Keywords HUNT1; smoking; pituitary adenoma; cancer; Obesity  
  Abstract Pituitary adenomas (PAs) account for about 13.5 % of all primary brain tumors and represent the third largest group of brain tumors after meningiomas and gliomas [1]. They are either hormone secreting or non-functioning tumors and mostly benign in nature. Due to their vicinity to the optic chiasm and their disturbance of hormonal equilibrium, PAs are associated with substantial morbidity. Knowledge about the etiology of PAs is scarce. No study to date has explored overweight and obesity as risk factors for PAs despite increasing evidence that body mass index (BMI) is associated with some primary brain tumor subgroups [2–5]. Smoking in relation to the risk of PA was assessed by two recent studies without demonstrating a clear association [6, 7]. The aim of this study was to investigate the association between BMI, smoking and the risk of incidental PA in the HUNT 1 study.  
  Address Department of Neurosurgery, Oslo University Hospital, Ulleval, 0450, Oslo, Norway, Markus.KH.Wiedmann@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0393-2990 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25903163 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1689  
Permanent link to this record
 

 
Author Wiedmann, M.; Brunborg, C.; Lindemann, K.; Johannesen, T.B.; Vatten, L.; Helseth, E.; Zwart, J.A. url  doi
  Title Smoking, obesity and the risk of pituitary adenoma: a large prospective cohort study (The HUNT Study) Type Journal Article
  Year 2016 Publication Eur J Epidemiol Abbreviated Journal European journal of epidemiology  
  Volume 31 Issue 1 Pages 95-98  
  Keywords HUNT1; smoking; pituitary adenoma; cancer; Obesity  
  Abstract Pituitary adenomas (PAs) account for about 13.5 % of all primary brain tumors and represent the third largest group of brain tumors after meningiomas and gliomas [1]. They are either hormone secreting or non-functioning tumors and mostly benign in nature. Due to their vicinity to the optic chiasm and their disturbance of hormonal equilibrium, PAs are associated with substantial morbidity. Knowledge about the etiology of PAs is scarce. No study to date has explored overweight and obesity as risk factors for PAs despite increasing evidence that body mass index (BMI) is associated with some primary brain tumor subgroups [2–5]. Smoking in relation to the risk of PA was assessed by two recent studies without demonstrating a clear association [6, 7]. The aim of this study was to investigate the association between BMI, smoking and the risk of incidental PA in the HUNT 1 study.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neurosurgery, Oslo University Hospital, Ulleval, 0450, Oslo, Norway. Markus.KH.Wiedman Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Wiedmann, MarkusBrunborg, CathrineLindemann, KristinaJohannesen, Tom BorgeVatten, LarsHelseth, EirikZwart, John AnkerengLetterNetherlands2015/04/24 06:00Eur J Epidemiol. 2016 Jan;31(1):95-8. doi: 10.1007/s10654-015-0033-6. Epub 2015 Apr 24. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Wiedmann2016 Serial 1787  
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