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Author (up) Aarhus, L.; Tambs, K.; Kvestad, E.; Engdahl, B. url  doi
  Title Childhood Otitis Media: A Cohort Study With 30-Year Follow-Up of Hearing (The HUNT Study) Type Journal Article
  Year 2015 Publication Ear Hear Abbreviated Journal Ear and hearing  
  Volume 36 Issue 3 Pages 302-308  
  Keywords Acute Disease; Adolescent; Adult; Audiometry, Pure-Tone; Child; Chronic Disease; Cohort Studies; Female; Follow-Up Studies; Hearing Loss/*epidemiology; Humans; Male; Middle Aged; Norway/epidemiology; Otitis Media/epidemiology; Otitis Media with Effusion/*epidemiology; Otitis Media, Suppurative/*epidemiology; Recurrence; Young Adult  
  Abstract OBJECTIVES: To study the extent to which otitis media (OM) in childhood is associated with adult hearing thresholds. Furthermore, to study whether the effects of OM on adult hearing thresholds are moderated by age or noise exposure. DESIGN: Population-based cohort study of 32,786 participants who had their hearing tested by pure-tone audiometry in primary school and again at ages ranging from 20 to 56 years. Three thousand sixty-six children were diagnosed with hearing loss; the remaining sample had normal childhood hearing. RESULTS: Compared with participants with normal childhood hearing, those diagnosed with childhood hearing loss caused by otitis media with effusion (n = 1255), chronic suppurative otitis media (CSOM; n = 108), or hearing loss after recurrent acute otitis media (rAOM; n = 613) had significantly increased adult hearing thresholds in the whole frequency range (2 dB/17-20 dB/7-10 dB, respectively). The effects were adjusted for age, sex, and noise exposure. Children diagnosed with hearing loss after rAOM had somewhat improved hearing thresholds as adults. The effects of CSOM and hearing loss after rAOM on adult hearing thresholds were larger in participants tested in middle adulthood (ages 40 to 56 years) than in those tested in young adulthood (ages 20 to 40 years). Eardrum pathology added a marginally increased risk of adult hearing loss (1-3 dB) in children with otitis media with effusion or hearing loss after rAOM. The study could not reveal significant differences in the effect of self-reported noise exposure on adult hearing thresholds between the groups with OM and the group with normal childhood hearing. CONCLUSIONS: This cohort study indicates that CSOM and rAOM in childhood are associated with adult hearing loss, underlining the importance of optimal treatment in these conditions. It appears that ears with a subsequent hearing loss after OM in childhood age at a faster rate than those without; however this should be confirmed by studies with several follow-up tests through adulthood.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Division of Mental Health, Norwegian Institute of Public Health, Division of Mental Health, Nydalen, Editor  
  Language Summary Language Original Title  
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  Notes Aarhus, LisaTambs, KristianKvestad, EllenEngdahl, BoengN01 DC62104/DC/NIDCD NIH HHS/N01-DC-6-2104/DC/NIDCD NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't2014/11/18 06:00Ear Hear. 2015 May-Jun;36(3):302-8. doi: 10.1097/AUD.0000000000000118. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Aarhus2015c Serial 1791  
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Author (up) Heuch, I.; Hagen, K.; Zwart, J.A.   
  Title Association between body height and chronic low back pain: a follow-up in the Nord-Trondelag Health Study Type Journal Article
  Year 2015 Publication BMJ Open Abbreviated Journal BMJ open  
  Volume 5 Issue 6 Pages e006983  
  Keywords HUNT2; HUNT3; Adult; Aged; Biomechanical Phenomena/physiology; *Body Height; Chronic Disease; Female; Follow-Up Studies; Humans; Low Back Pain/*epidemiology; Male; Middle Aged; Norway/epidemiology; Prospective Studies; Risk Factors  
  Abstract OBJECTIVE: To study potential associations between body height and subsequent occurrence of chronic low back pain (LBP). DESIGN: Prospective cohort study. SETTING: The North-Trondelag Health Study (HUNT). Data were obtained from a whole Norwegian county in the HUNT2 (1995-1997) and HUNT3 (2006-2008) surveys. PARTICIPANTS: Altogether, 3883 women and 2662 men with LBP, and 10,059 women and 8725 men without LBP, aged 30-69 years, were included at baseline and reported after 11 years whether they suffered from LBP. MAIN OUTCOME MEASURE: Chronic LBP, defined as pain persisting for 3 months during the previous year. RESULTS: Associations between body height and risk and recurrence of LBP were evaluated by generalised linear modelling. Potential confounders, such as BMI, age, education, employment, physical activity, smoking, blood pressure and lipid levels were adjusted for. In women with no LBP at baseline and body height >/= 170 cm, a higher risk of LBP was demonstrated after adjustment for other risk factors (relative risk 1.19, 95% CI 1.03 to 1.37; compared with height  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neurology and FORMI, Oslo University Hospital, Oslo, Norway.Department of Mathematics, Editor  
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  Call Number HUNT @ maria.stuifbergen @ Heuch2015 Serial 1818  
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Author (up) Jorgensen, P.; Langhammer, A.; Krokstad, S.; Forsmo, S. url  doi
  Title Mortality in persons with undetected and diagnosed hypertension, type 2 diabetes, and hypothyroidism, compared with persons without corresponding disease – a prospective cohort study; The HUNT Study, Norway Type Journal Article
  Year 2017 Publication BMC Family Practice Abbreviated Journal BMC Fam Pract  
  Volume 18 Issue 1 Pages 98  
  Keywords Chronic disease; Diabetes; Hypertension; Primary care; Public health; Thyroid disorders  
  Abstract BACKGROUND: Suggested strategies in reducing the impact of non-communicable diseases (NCD) are early diagnosing and screening. We have limited proof of benefit of population screening for NCD. Increased mortality in persons with diagnosed NCD has been shown for decades. However, mortality in undetected NCD has barely been studied. This paper explores whether all-cause mortality differed between persons with diagnosed hypothyroidism, type 2 diabetes (T2DM), and hypertension, compared with persons with undetected-, and with persons without the corresponding disease. METHODS: A prospective cohort study of the general population in Nord-Trondelag, Norway. Persons >/=20 years at baseline 1995-97 were followed until death or June 15, 2016. Cox proportional hazards models were used to compute age and multiple adjusted hazard ratios (HR) with 95% confidence intervals (CI) for the association between disease status and all-cause mortality. The number of participants in the hypothyroidism study was 31,960, in the T2DM study 37,957, and in the hypertension study 63,371. RESULTS: Mortality was increased in persons with diagnosed type 2 diabetes and hypertension, compared to persons without corresponding disease; HR 1.69 (95% CI 1.55-1.84) and HR 1.23 (95% CI 1.09-1.39), respectively. Among persons with undetected T2DM, the HR was 1.21 (95% CI 1.08-1.37), whilst among undetected hypothyroidism and hypertension, mortality was not increased compared with persons without the diseases. Further, the association with mortality was stronger in persons with long duration of T2DM (HR 1.96 (95% CI 1.57-2.44)) and hypertension (HR 1.32 (95% CI 1.17-1.49)), compared with persons with short duration (HR 1.29 (1.09-1.53) and HR 1.16 (1.03-1-30) respectively). CONCLUSIONS: Mortality was increased in persons with diagnosed T2DM and hypertension, and in undetected T2DM, compared with persons without the diseases. The strength of the association with mortality in undetected T2DM was however lower compared with persons with diagnosed T2DM, and mortality was not increased in persons with undetected hypothyroidism and hypertension, compared with persons without the diseases. Thus, future research needs to test more thoroughly if early diagnosing of these diseases, such as general population screening, is beneficial for health.  
  Address Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Postbox 8905, 7491, Trondheim, Norway  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1471-2296 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29212453; PMCID:PMC5719734 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1935  
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Author (up) Myrtveit, S.M.; Wilhelmsen, I.; Petrie, K.J.; Skogen, J.C.; Sivertsen, B. url  doi
  Title What characterizes individuals developing chronic whiplash?: The Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2013 Publication Journal of Psychosomatic Research Abbreviated Journal J Psychosom Res  
  Volume 74 Issue 5 Pages 393-400  
  Keywords Adaptation, Psychological; Adult; Aged; Anxiety Disorders/diagnosis/psychology; Chronic Disease; Cohort Studies; Compensation and Redress; Female; Health Services/utilization; Health Surveys; Humans; Illness Behavior; Male; Middle Aged; Norway; Pain Measurement/psychology; Prescription Drugs/therapeutic use; Prognosis; Prospective Studies; Risk Factors; Somatoform Disorders/diagnosis/psychology; Utilization Review; Whiplash Injuries/*diagnosis/*psychology; Young Adult  
  Abstract OBJECTIVE: Most individuals experiencing whiplash accidents recover rapidly. A considerable proportion, however, develop chronic symptoms. Psychological factors may slow recovery, possibly by increasing the likelihood of other symptoms being misattributed to, and amplified by the whiplash injury. We aimed to investigate how pre-injury mental and somatic symptoms, self-rated health, use of health-services and medications, health-behavior and socio-demographics predict the development of chronic whiplash. METHODS: Data from two waves of a large, population based study (HUNT2 (baseline) and HUNT3) were used. Individuals reporting no whiplash at baseline were identified in HUNT3. Characteristics reported at baseline were compared between those who had developed chronic whiplash in HUNT3 (n=199) and those who had not (n=20,600), using Pearson's chi-squared tests, independent sample t-tests and logistic regression analyses. RESULTS: Individuals developing chronic whiplash reported worse baseline health than those reporting no chronic whiplash. Poor self-rated health was a strong risk factor for subsequent chronic whiplash (OR=2.26, 95%CI: 1.68-3.04). Musculoskeletal pain also increased the risk (OR=1.21, 95%CI: 1.15-1.26), as did diffuse somatic symptoms (OR=2.09, 95%CI: 1.47-2.96), use of different health services (OR=1.31, 95%CI: 1.19-1.45), high use of medications (OR=1.28, 95%CI: 1.14-1.43) and symptoms of anxiety (OR=1.93, 95%CI: 1.39-2.68). Physical activity was protective (OR=0.67, 95%CI: 0.49-0.91). Most socio-demographic variables were not significantly associated with chronic whiplash. CONCLUSION: Poor somatic and mental pre-injury health increased the risk of subsequent chronic whiplash. This suggests that chronic whiplash is not merely an organic disorder, and highlights the importance of individual expectations, symptom reattribution and amplification in development of chronic whiplash.  
  Address Department of Clinical Medicine II, University of Bergen, Bergen, Norway. makalani.myrtveit@med.uib.no  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-3999 ISBN Medium  
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  Notes PMID:23597326 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1413  
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Author (up) Skogen, J.C.; Knudsen, A.K.; Mykletun, A.; Nesvag, S.; Overland, S. url  doi
  Title Alcohol consumption, problem drinking, abstention and disability pension award. The Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2012 Publication Addiction (Abingdon, England) Abbreviated Journal Addiction  
  Volume 107 Issue 1 Pages 98-108  
  Keywords Adult; Alcohol Drinking/*epidemiology; Alcoholism/*epidemiology; Chronic Disease; Confounding Factors (Epidemiology); Disabled Persons/statistics & numerical data; Female; Health Behavior; *Health Status; Humans; Male; Middle Aged; Norway/epidemiology; Pensions/*statistics & numerical data; Retirement/statistics & numerical data; Sick Leave/statistics & numerical data; Social Class; Social Security/*statistics & numerical data; Temperance/*statistics & numerical data; Young Adult  
  Abstract AIMS: To examine associations of abstention, alcohol consumption and problem drinking with subsequent disability pensioning (DP), and whether previous excessive consumption ('sick-quitting') could explain some of the increased risk for DP among abstainers. DESIGN: Prospective population-based study. SETTING AND PARTICIPANTS: Data were from two waves of the Nord-Trondelag Health Study (HUNT) linked with the national insurance database. The two main analyses included 37,729 (alcohol consumption) and 34,666 (problem drinking) participants. MEASUREMENTS: Alcohol consumption was measured by self-reported consumption, while problem drinking was assessed by the Cut down, Annoyed, Guilt, Eye-opener (CAGE) questionnaire. Information on subsequent DP, including diagnosis for which the DP was awarded, was gathered from the national insurance database. Covariates included somatic illness and symptoms, mental health, health-related behaviour, socio-economic status and social activity. FINDINGS: Those reporting the highest level of alcohol consumption were not at increased risk for DP [hazard ratio (HR) 1.12, 95% confidence interval (CI): 0.92-1.38], whereas problem drinking was a strong predictor (HR 2.79, 95% CI: 2.08-3.75) compared to their corresponding reference groups. Alcohol abstainers were also at increased risk for DP, but among them, the previous consumers (HR 1.95, 95% CI: 1.48-2.57) and previous excessive consumers (HR 1.67, 95% CI: 1.01-2.74) were at higher risk for DP than constant abstainers. CONCLUSIONS: Problem drinking is linked to subsequent requirement for a disability pension but mere alcohol consumption is not. This is partly explained by 'sick-quitting'.  
  Address Research Centre for Health Promotion, Faculty of Psychology, University of Bergen, Bergen, Norway  
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  Language English Summary Language Original Title  
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  ISSN 0965-2140 ISBN Medium  
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  Notes PMID:21707810 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1576  
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Author (up) Sun, Y.-Q.; Langhammer, A.; Skorpen, F.; Chen, Y.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway Type Journal Article
  Year 2017 Publication BMJ Open Abbreviated Journal BMJ Open  
  Volume 7 Issue 6 Pages e017256  
  Keywords 25-hydroxyvitamin D (25(OH)D); all-cause mortality; chronic diseases; prospective cohort study; vitamin D  
  Abstract OBJECTIVE: To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association. DESIGN: A population-based prospective cohort study. SETTING: Nord-Trondelag County, Norway. PARTICIPANTS: A random sample (n=6613) of adults aged 20 years or older in a cohort. METHODS: Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in blood samples collected at baseline (n=6377). Mortality was ascertained from the Norwegian National Registry. Cox regression models were applied to estimate the HRs with 95% CIs for all-cause mortality in association with serum 25(OH)D levels after adjustment for a wide spectrum of confounding factors as well as chronic diseases at baseline. RESULTS: The median follow-up time was 18.5 years, during which 1539 subjects died. The HRs for all-cause mortality associated with the first quartile level of 25(OH)D (<34.5 nmol/L) as compared with the fourth quartile (>/=58.1 nmol/L) before and after adjustment for chronic diseases at baseline were 1.30 (95% CI 1.11 to 1.51) and 1.27 (95% CI 1.09 to 1.48), respectively. In the subjects without chronic diseases at baseline and with further exclusion of the first 3 years of follow-up, the corresponding adjusted HR was 1.34 (95% CI 1.09 to 1.66). CONCLUSIONS: Low serum 25(OH)D level was associated with increased all-cause mortality in a general Norwegian population. The association was not notably influenced by existing chronic diseases.  
  Address Department of Public Health and Nursing, Norwegian University of Science and Technology, NTNU, Trondheim, Norway  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2044-6055 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28674149; PMCID:PMC5734252 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1990  
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