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Author Asvold, B.O.; Midthjell, K.; Krokstad, S.; Rangul, V.; Bauman, A. url  doi
  Title Prolonged sitting may increase diabetes risk in physically inactive individuals: an 11 year follow-up of the HUNT Study, Norway Type Journal Article
  Year 2017 Publication Diabetologia Abbreviated Journal Diabetologia  
  Volume 60 Issue 5 Pages 830-835  
  Keywords Adult; Body Mass Index; Diabetes Mellitus, Type 2/*epidemiology/metabolism; Exercise/physiology; Female; Humans; Incidence; Leisure Activities; Male; Middle Aged; *Sedentary Lifestyle; Epidemiology; Sedentary lifestyle; Type 2 diabetes mellitus  
  Abstract AIMS/HYPOTHESIS: We examined the association between sitting time and diabetes incidence, overall and by strata of leisure-time physical activity and BMI. METHODS: We followed 28,051 adult participants of the Nord-Trondelag Health Study (the HUNT Study), a population-based study, for diabetes incidence from 1995-1997 to 2006-2008 and estimated HRs of any diabetes by categories of self-reported total daily sitting time at baseline. RESULTS: Of 28,051 participants, 1253 (4.5%) developed diabetes during 11 years of follow-up. Overall, sitting >/=8 h/day was associated with a 17% (95% CI 2, 34) higher risk of developing diabetes compared with sitting </=4 h/day, adjusted for age, sex and education. However, the association was attenuated to a non-significant 9% (95% CI -5, 26) increase in risk after adjustment for leisure-time physical activity and BMI. The association between sitting time and diabetes risk differed by leisure-time physical activity (p Interaction = 0.01). Among participants with low leisure-time physical activity (</=2 h light activity per week and no vigorous activity), sitting 5-7 h/day and >/=8 h/day were associated with a 26% (95% CI 2, 57) and 30% (95% CI 5, 61) higher risk of diabetes, respectively, compared with sitting </=4 h/day. There was no corresponding association among participants with high leisure-time physical activity (>/=3 h light activity or >0 h vigorous activity per week). There was no statistical evidence that the association between sitting time and diabetes risk differed by obesity (p Interaction = 0.65). CONCLUSIONS/INTERPRETATION: Our findings suggest that total sitting time has little association with diabetes risk in the population as a whole, but prolonged sitting may contribute to an increased diabetes risk among physically inactive people.  
  Address School of Public Health, Sydney University, Sydney, NSW, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-186X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28054097 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1879  
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Author Hjort, R.; Ahlqvist, E.; Carlsson, P.-O.; Grill, V.; Groop, L.; Martinell, M.; Rasouli, B.; Rosengren, A.; Tuomi, T.; Asvold, B.O.; Carlsson, S. url  doi
  Title Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study Type Journal Article
  Year 2018 Publication Diabetologia Abbreviated Journal Diabetologia  
  Volume 61 Issue 6 Pages 1333-1343  
  Keywords Adult; Aged; Autoantibodies/blood; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2/*epidemiology; Female; Humans; Insulin Resistance; Insulin-Secreting Cells/metabolism; Latent Autoimmune Diabetes in Adults/*complications/*diagnosis/*epidemiology; Male; Middle Aged; Norway/epidemiology; Obesity/*complications/epidemiology; Odds Ratio; Overweight/*complications/epidemiology; Prospective Studies; Risk Factors; Sweden; Young Adult; *Andis; *ANDiU; *Body mass index; *Case-control study; *Estrid; *HUNT Study; *Lada; *Latent autoimmune diabetes in adults; *Prospective study; *Type 2 diabetes  
  Abstract AIMS/HYPOTHESIS: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. METHODS: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. RESULTS: In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; <median) (OR 4.25; 95% CI 2.76, 6.52) but present also in LADA with high GADA (OR 2.14; 95% CI 1.42, 3.24). In the Swedish data, obese vs normal weight LADA patients had lower GADA levels, better beta cell function, and were more likely to have low-risk HLA-genotypes. The combination of overweight and family history of diabetes (FHD) conferred an OR of 4.57 (95% CI 3.27, 6.39) for LADA and 24.51 (95% CI 17.82, 33.71) for type 2 diabetes. Prospective data from HUNT indicated even stronger associations; HR for LADA was 6.07 (95% CI 3.76, 9.78) for obesity and 7.45 (95% CI 4.02, 13.82) for overweight and FHD. CONCLUSIONS/INTERPRETATION: Overweight/obesity is associated with increased risk of LADA, particularly when in combination with FHD. These findings support the hypothesis that, even in the presence of autoimmunity, factors linked to insulin resistance, such as excessive weight, could promote onset of diabetes.  
  Address Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-186X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29589073 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2098  
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Author Rasouli, B.; Ahlbom, A.; Andersson, T.; Grill, V.; Midthjell, K.; Olsson, L.; Carlsson, S. url  doi
  Title Alcohol consumption is associated with reduced risk of Type 2 diabetes and autoimmune diabetes in adults: results from the Nord-Trondelag health study Type Journal Article
  Year 2013 Publication Diabetic Medicine : a Journal of the British Diabetic Association Abbreviated Journal Diabet Med  
  Volume 30 Issue 1 Pages 56-64  
  Keywords Adult; Aged; Alcohol Drinking/*epidemiology; Diabetes Mellitus, Type 1/*epidemiology; Diabetes Mellitus, Type 2/*epidemiology; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Norway/epidemiology; Risk Factors  
  Abstract AIMS: We investigated the influence of different aspects of alcohol consumption on the risk of Type 2 diabetes and autoimmune diabetes in adults. METHODS: We used data from the Nord-Trondelag Health Survey (HUNT) study, in which all adults aged >/= 20 years from Nord-Trondelag County were invited to participate in three surveys in 1984-1986, 1995-1997 and 2006-2008. Patients with diabetes were identified using self-reports, and participants with onset age >/= 35 years were classified as having Type 2 diabetes if they were negative for anti-glutamic acid decarboxylase (n = 1841) and as having autoimmune diabetes if they were positive for anti-glutamic acid decarboxylase (n = 140). Hazard ratios of amount and frequency of alcohol use, alcoholic beverage choice, and binge drinking and alcohol use disorders were estimated. RESULTS: Moderate alcohol consumption (adjusted for confounders) was associated with a reduced risk of Type 2 diabetes in men, but not in women (hazard ratio for men 10-15 g/day 0.48, 95% CI 0.28-0.77; hazard ratio for women >/= 10 g/day 0.81, 95% CI 0.33-1.96). The reduced risk was primarily linked to consumption of wine [hazard ratio 0.93, 95% CI 0.87-0.99 (per g/day)]. No increased risk was seen in participants reporting binge drinking or in problem drinkers. The results were also compatible with a reduced risk of autoimmune diabetes associated with alcohol consumption [hazard ratio 0.70, 95% CI 0.45-1.08 (frequent consumption) and hazard ratio 0.36, 95% CI 0.13-0.97 (2-7 g/day)]. CONCLUSIONS: Moderate alcohol consumption associates with reduced risk of both Type 2 diabetes and autoimmune diabetes. A protective effect of alcohol intake may be limited to men. High alcohol consumption does not seem to carry an increased risk of diabetes.  
  Address Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. bahareh.rasouli@ki.se  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3071 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22612671 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1406  
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Author Rasouli, B.; Grill, V.; Midthjell, K.; Ahlbom, A.; Andersson, T.; Carlsson, S. url  doi
  Title Smoking is associated with reduced risk of autoimmune diabetes in adults contrasting with increased risk in overweight men with type 2 diabetes: a 22-year follow-up of the HUNT study Type Journal Article
  Year 2013 Publication Diabetes Care Abbreviated Journal Diabetes Care  
  Volume 36 Issue 3 Pages 604-610  
  Keywords Adult; Diabetes Mellitus, Type 1/*epidemiology/*etiology; Diabetes Mellitus, Type 2/*epidemiology; Female; Humans; Male; Middle Aged; Overweight/*epidemiology; Smoking/*adverse effects; Young Adult  
  Abstract OBJECTIVE: To investigate the association between smoking habits and risk of autoimmune diabetes in adults and of type 2 diabetes. RESEARCH DESIGN AND METHODS: We used data from the three surveys of the Nord-Trondelag Health Study, spanning 1984-2008 and including a cohort of 90,819 Norwegian men (48%) and women (52%) aged >/=20 years. Incident cases of diabetes were identified by questionnaire and classified as type 2 diabetes (n = 1,860) and autoimmune diabetes (n = 140) based on antibodies to glutamic decarboxylase (GADA) and age at onset of diabetes. Hazard ratios (HRs) adjusted for confounders were estimated by Cox proportional hazards regression models. RESULTS: The risk of autoimmune diabetes was reduced by 48% (HR 0.52 [95% CI 0.30-0.89]) in current smokers and 58% in heavy smokers (0.42 [0.18-0.98]). The reduced risk was positively associated with number of pack-years. Heavy smoking was associated with lower levels of GADA (P = 0.001) and higher levels of C-peptide (964 vs. 886 pmol/L; P = 0.03). In contrast, smoking was associated with an increased risk of type 2 diabetes, restricted to overweight men (1.33 [1.10-1.61]). Attributable proportion due to an interaction between overweight and heavy smoking was estimated to 0.40 (95% CI 0.23-0.57). CONCLUSIONS: In this epidemiological study, smoking is associated with a reduced risk of autoimmune diabetes, possibly linked to an inhibitory effect on the autoimmune process. An increased risk of type 2 diabetes was restricted to overweight men.  
  Address Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. bahareh.rasouli@ki.se  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0149-5992 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23172971; PMC3579345 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1569  
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