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Author Aamaas O, Hoien F   
  Title Forekomst av hypoglycemi i en ikke-selektert befolkning Type Book Whole
  Year 2005 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis Diploma thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:699. Hovedoppgave, NTNU, 2005 HUNT2 Approved no  
  Call Number Serial 681  
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Author Aamodt AH, Borch-Iohnsen B, Hagen K, Stovner LJ, Asberg A, Zwart JA   
  Title Headache prevalence related to haemoglobin and ferritin. The HUNT Study Type Journal Article
  Year 2004 Publication Cephalalgia 2004 Abbreviated Journal  
  Volume 24 Issue Pages 758-62  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:464. HUNT2 Approved no  
  Call Number Serial 450  
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Author Aamodt AH, Stovner LJ, Hagen K, Brathen G, Zwart JA   
  Title Headache prevalence related to smoking and alcohol use. The Head-HUNT Study Type Journal Article
  Year 2006 Publication European Journal of Neurologi 2006 Abbreviated Journal  
  Volume 13 Issue Pages 1233-8  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:778. HUNT2 Approved no  
  Call Number Serial 760  
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Author Aamodt AH, Stovner LJ, Hagen K, Zwart JA   
  Title Comorbidity of headache and gastrointestinal complaints. The Head-HUNT Study Type Journal Article
  Year 2007 Publication Cephalalgia 2007 Abbreviated Journal  
  Volume 28 Issue Pages 144-51  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:974. HUNT2 Approved no  
  Call Number Serial 946  
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Author Aamodt AH, Stovner LJ, Midthjell K, Hagen K, Zwart JA   
  Title Headache prevalence related to diabetes mellitus. The Head-HUNT Study Type Journal Article
  Year 2007 Publication Eur J Neurol. 2007 Abbreviated Journal  
  Volume 14(7) Issue Pages 738-44  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:825. HUNT2 Approved no  
  Call Number Serial 805  
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Author Aamodt AH   
  Title Comorbidity of headache and migraine in the Nord-Trøndelag Health Study 1995-97 Type Book Whole
  Year 2008 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis Doctoral thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:878. Doktorgradsavhandling, NTNU, 2008 HUNT2 Approved no  
  Call Number Serial 854  
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Author Aarhus L, Kvestad E, Tambs K, Engdahl B   
  Title Aldersrelatert hørselstap: En kort oppsummering av resultater fra Hørselsundersøkelsen i Nord-Trøndelag Type Journal Article
  Year 2012 Publication Norsk Epidemiologi 2012 Abbreviated Journal  
  Volume 22(2) Issue Pages 175-6  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:1267. HUNT2 Approved no  
  Call Number Serial 1224  
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Author Aas I   
  Title Sammenhengen mellom lungesymptomer, kjæledyr i barndomshjem og nåværende hjemmemiljø Type Book Whole
  Year 2004 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:698. Hovedoppgave, NTNU, 2004 HUNT2 Approved no  
  Call Number Serial 680  
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Author Aegidius K, Zwart JA, Hagen K, Schei B, Stovner LJ   
  Title Oral contraceptives and increased headache prevalence. The Head-HUNT Study Type Journal Article
  Year 2006 Publication Neurology 2006 Abbreviated Journal  
  Volume 66 Issue Pages 349-53  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:726. HUNT2 Approved no  
  Call Number Serial 708  
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Author Aegidius K, Zwart JA, Hagen K, Stovner L   
  Title The effect of pregnancy and parity on hearache prevalence: The Head-HUNT study Type Journal Article
  Year 2009 Publication Headache 2009 Abbreviated Journal  
  Volume 49 Issue Pages 851-9  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:1023. HUNT2 Approved no  
  Call Number Serial 990  
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Author Aegidius KL, Zwart JA, Hagen K, Dyb G, Holmen TL, Stovner LJ   
  Title Increased headache prevelence in female adolescents and adult women with early menarche. The Head-HUNT studies Type Journal Article
  Year 2010 Publication Eur J Neurol. 2010 Jul 15. [Epub ahead of print] Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:1040. HUNT2 Approved no  
  Call Number Serial 1006  
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Author Aegidius KL, Zwart JA, Hagen K, Schei B, Stovner LJ   
  Title Hormone replacement therapy and headache prevalence in postmenopausal women.The Head-HUNT study Type Journal Article
  Year 2007 Publication Er J Neurol 2007 Abbreviated Journal  
  Volume 14 Issue Pages 73-78  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:798. HUNT2 Approved no  
  Call Number Serial 780  
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Author Ahmed S, Thomas G, Ghoussaini M et al   
  Title Newly discovered breast cancer susceptiblity loci on 3p24 and 17q23.2 Type Journal Article
  Year 2009 Publication Nature Genetics 2009 Abbreviated Journal  
  Volume 41 Issue Pages 585-90  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:999. HUNT2 Approved no  
  Call Number Serial 967  
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Author Aksnes LH   
  Title Health in long-term survivors of bone sarcoma Type Book Whole
  Year 2009 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis Doctoral thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:1371. Doktorgradsavhandling, Oslo, 2009 HUNT2 Approved no  
  Call Number Serial 1325  
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Author Aksnes LH, Bauer HC, Dahl AA, Fossa SD, Hjorth L, Jebsen N, Lernedal H, Hall KS.   
  Title Health status at long-term follow-up in patients treated for extremity localized Ewing Sarcoma or osteosarcoma: a Scandinavian sarcoma group study. Type Journal Article
  Year 2009 Publication Pediatr Blood Cancer. 2009 Jul Abbreviated Journal  
  Volume 53(1) Issue Pages 84-9.  
  Keywords HUNT2  
  Abstract BACKGROUND: The purpose of this study was to evaluate late effects and symptom complaints in long-term survivors (>5 years) of Extremity Bone Sarcoma (EBS survivors). The results were compared with findings in age- and gender-matched individuals from the general population (NORMs). PATIENTS AND METHODS: Among 155 EBS survivors approached, 133 (86%) were included, and 110 of them (83%) attended an outpatient examination. Health status was evaluated by a mailed questionnaire concerning demographic and current health issues, and physical examinations at the outpatient clinic. Age- and gender-adjusted normative controls were drawn from participants of the Health Study of Nord-Trøndelag County (HUNT 2). RESULTS: Median age at follow-up was 29 (15-57) years. Median follow-up was 12 (6-22) years. Of EBS survivors 42% had > or =1 somatic disease, 33% had ototoxicity and 13% had reduced renal function. EBS survivors were more likely to have heart disease (odds ratio [OR], 7.9; 95% confidence interval [95% CI], 2.5-25.3; P = 0.001), hypertension (OR, 3.4; 95% CI, 1.1-10.1; P = 0.03) and thyroid disease (OR, 3.0; 95% CI, 1.1-8.3; P = 0.04) compared to NORMs. EBS survivors reported more diarrhoea (29% vs. 19%, P = 0.02), palpitations (23% vs. 13%, P = 0.01) and shortness of breath (11% vs. 5%, P = 0.01) than NORMs. CONCLUSIONS: EBS survivors have poorer health status compared to age- and gender-matched controls. Long-term follow-up of these patients is therefore mandatory. Copyright 2009 Wiley-Liss, Inc.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:978. HUNT2 Approved no  
  Call Number Serial 950  
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Author Aldridge A   
  Title The association between weight change and cardiovascular mortality: The HUNT study, Norway Type Book Whole
  Year 2011 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT1; HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis Diploma thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:1128. HUNT1, HUNT2 Approved no  
  Call Number Serial 1090  
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Author Almkvist, O.; Bosnes, O.; Bosnes, I.; Stordal, E. url  doi
  Title Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study Type Journal Article
  Year 2017 Publication BMJ Open Abbreviated Journal BMJ Open  
  Volume 7 Issue 5 Pages e013586  
  Keywords Hunt; disease; health; long-term memory; short-term memory; subjective memory  
  Abstract BACKGROUND: Subjective memory is commonly considered to be a unidimensional measure. However, theories of performance-based memory suggest that subjective memory could be divided into more than one dimension. OBJECTIVE: To divide subjective memory into theoretically related components of memory and explore the relationship to disease. METHODS: In this study, various aspects of self-reported memory were studied with respect to demographics and diseases in the third wave of the HUNT epidemiological study in middle Norway. The study included all individuals 55 years of age or older, who responded to a nine-item questionnaire on subjective memory and questionnaires on health (n=18 633). RESULTS: A principle component analysis of the memory items resulted in two memory components; the criterion used was an eigenvalue above 1, which accounted for 54% of the total variance. The components were interpreted as long-term memory (LTM; the first component; 43% of the total variance) and short-term memory (STM; the second component; 11% of the total variance). Memory impairment was significantly related to all diseases (except Bechterew's disease), most strongly to brain infarction, heart failure, diabetes, cancer, chronic obstructive pulmonary disease and whiplash. For most diseases, the STM component was more affected than the LTM component; however, in cancer, the opposite pattern was seen. CONCLUSIONS: Subjective memory impairment as measured in HUNT contained two components, which were differentially associated with diseases.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2044-6055 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28490551; PMCID:PMC5566596 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1874  
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Author Antonsen S   
  Title Motivasjon for deltakelse i helseundersøkelser Type Journal Article
  Year 2005 Publication Norsk Epidemiologi 2005 Abbreviated Journal  
  Volume 15(1) Issue Pages 99-109  
  Keywords HUNT1; HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:707. HUNT1, HUNT2 Approved no  
  Call Number Serial 689  
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Author Anttila, V.; Winsvold, B.S.; Gormley, P.; Kurth, T.; Bettella, F.; McMahon, G.; Kallela, M.; Malik, R.; de Vries, B.; Terwindt, G.; Medland, S.E.; Todt, U.; McArdle, W.L.; Quaye, L.; Koiranen, M.; Ikram, M.A.; Lehtimaki, T.; Stam, A.H.; Ligthart, L.; Wedenoja, J.; Dunham, I.; Neale, B.M.; Palta, P.; Hamalainen, E.; Schurks, M.; Rose, L.M.; Buring, J.E.; Ridker, P.M.; Steinberg, S.; Stefansson, H.; Jakobsson, F.; Lawlor, D.A.; Evans, D.M.; Ring, S.M.; Farkkila, M.; Artto, V.; Kaunisto, M.A.; Freilinger, T.; Schoenen, J.; Frants, R.R.; Pelzer, N.; Weller, C.M.; Zielman, R.; Heath, A.C.; Madden, P.A.F.; Montgomery, G.W.; Martin, N.G.; Borck, G.; Gobel, H.; Heinze, A.; Heinze-Kuhn, K.; Williams, F.M.K.; Hartikainen, A.-L.; Pouta, A.; van den Ende, J.; Uitterlinden, A.G.; Hofman, A.; Amin, N.; Hottenga, J.-J.; Vink, J.M.; Heikkila, K.; Alexander, M.; Muller-Myhsok, B.; Schreiber, S.; Meitinger, T.; Wichmann, H.E.; Aromaa, A.; Eriksson, J.G.; Traynor, B.J.; Trabzuni, D.; Rossin, E.; Lage, K.; Jacobs, S.B.R.; Gibbs, J.R.; Birney, E.; Kaprio, J.; Penninx, B.W.; Boomsma, D.I.; van Duijn, C.; Raitakari, O.; Jarvelin, M.-R.; Zwart, J.-A.; Cherkas, L.; Strachan, D.P.; Kubisch, C.; Ferrari, M.D.; van den Maagdenberg, A.M.J.M.; Dichgans, M.; Wessman, M.; Smith, G.D.; Stefansson, K.; Daly, M.J.; Nyholt, D.R.; Chasman, D.I.; Palotie, A. url  doi
  Title Genome-wide meta-analysis identifies new susceptibility loci for migraine Type Meta-Analysis
  Year 2013 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 45 Issue 8 Pages 912-917  
  Keywords Cerebellum/metabolism; Computational Biology; Frontal Lobe/metabolism; *Genetic Loci; *Genetic Predisposition to Disease; *Genome-Wide Association Study; Humans; Migraine Disorders/*genetics; Polymorphism, Single Nucleotide; Quantitative Trait Loci; HUNT3  
  Abstract Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5x10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.  
  Address Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. anttila@atgu.mgh.harvard.edu  
  Corporate Author International Headache Genetics Consortium Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23793025 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1341  
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Author Arnes M   
  Title Lifestyle in hypertensive patients – a study of lifestyle related cardiovascular risk factors in hypertensive patients based on the Nord-Trøndelag Health Study 2006-2008 Type Book Whole
  Year 2009 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT3  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:995. Studentoppgave, NTNU, 2009 HUNT3 Approved no  
  Call Number Serial 963  
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Author Arnesen E, Holmen J, Tell GS, Bjertness E, Sogaard AJ, Stoltenberg C, Magnus P   
  Title CONOR – en satsing på årsaksforskning Type Report
  Year 2004 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HUNT_ID:433. HUNT2 Approved no  
  Call Number Serial 422  
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Author Asberg A   
  Title Epidemiological studies in hereditary hemochromatosis. Prevalence, morbidity and benefit of screening Type Book Whole
  Year 2003 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2  
  Abstract <p>Arvelig hemokromatose skyldes en medfødt tendens til å ta opp mer jern fra maten enn det kroppen har bruk for. Overskuddsjernet kan ikke utskilles; det hoper seg opp i lever og andre organer, og etter 30-årsalderen kan tilstanden bli symptomatisk. De som blir syke, kan være plaget av slapphet, leddsmerter, lever- og hjertesykdom, sukkersyke og impotens. Skrumplever med økt fare for leverkreft er den mest alvorlige komplikasjonen. Behandlingen er årelating. Hvis behandling startes før leveren er alvorlig skadet, har pasienten en normal forventet livslengde. De aller fleste pasienter med arvelig hemokromatose er homozygote for C282Y-mutasjonen i <i>HFE</i>-genet på kromosom 6. I Nordvest-Europa er vel 0,5 % av befolkningen homozygote.</p> <p>Screening for arvelig hemokromatose synes nærliggende: Tilstanden er relativt hyppig forekommende, den har en lang asymptomatisk fase der den er lett å påvise, og behandling vil effektivt forhindre plager og forlenge livet. Likevel er det tvil om samfunnet bør starte screening for arvelig hemokromatose. Vi vet ikke hvor mange med tilstanden som blir alvorlig syke, og dermed er det vanskelig å vurdere nytten av screening. Kostnaden av screening kjenner vi heller ikke.</p> <p>Disse problemene ble studert i de arbeidene avhandlingen bygger på. Utgangspunktet var den store helseundersøkelsen i Nord-Trøndelag i 1995-97 (HUNT), der alle innbyggere over 20 år ble invitert til å delta. Blodprøver ble tatt av 65238 personer. Screeningtesten var transferrinmetning i serum.</p> <p>Vi definerte <i>fenotypisk</i> hemokromatose som bekreftet høy s-transferrinmeting, høy s-ferritin og ingen andre forklaringer på disse funn etter en omfattende undersøkelse hos gastroenterolog. Leverbiopsi ble tatt av de fleste pasientene. <i>Genotypisk</i> hemokromatose definerte vi som homozygoti for C282Y-mutasjonen. Kun personer med bekreftet høy s-transferrinmetning ble genotypet.</p> <p>Vi påviste fenotypisk hemokromatose hos 177 menn og 92 kvinner. Fra før var det kjent 19 menn og 7 kvinner med tilstanden i Nord-Trøndelag. Hyppigheten av screeningoppdaget <i>fenotypisk</i> hemokromatose estimerte vi til 0,68 % hos menn og 0,34 % hos kvinner. Denne forskjellen var ventet, fordi kvinner har lavere jerninntak enn menn, og større jerntap (menstruasjon, barnefødsler). Hyppigheten av <i>genotypisk</i> hemokromatose var minst 0,68 %. Personer med mutasjonene C282Y/C282Y, C282Y/H63D og C282Y/S65C hadde økt risiko for å få diagnosen fenotypisk hemokromatose.</p> <p>Sykeligheten hos personer med screeningoppdaget hemokromatose var mindre enn ventet. Nesten alle hadde økt jerninnhold i leveren, og 4 menn hadde skrumplever, men med få andre unntak var personer med screeningoppdaget hemokromatose like friske som resten av befolkningen. Likevel viste våre beregninger at 7-8 leveår kan spares ved fenotypisk screening av 1000 menn i 30-årsalderen, fordi noen få menn blir alvorlig syke hvis tilstanden ikke oppdages i tide.</p> <p>Screeningkostnaden ble beregnet til 14500 kroner per 1000 menn, når hemokromatosescreening er en del av en etablert helseundersøkelse.</p>  
  Address  
  Corporate Author Thesis Doctoral thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  Area Expedition Conference  
  Notes HUNT_ID:319. Dr. med., NTNU, februar 2003 HUNT2 Approved no  
  Call Number Serial 318  
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Author Asberg A, Hveem K, Kruger O, Bjerve KS   
  Title Persons with screening-detected haemochromatosis: as healthy as the general population? Type Journal Article
  Year 2002 Publication Scand J Gastroenterol 2002 Jun Abbreviated Journal  
  Volume 37(6) Issue Pages 719-24  
  Keywords HUNT2  
  Abstract <p>Dept of Clinical Chemistry, Trondheim University Hospital, Norway. arne.asberg@rit.no</p> <p>BACKGROUND: Hereditary haemochromatosis (HH) is a common genetic disease leading to iron deposition in the liver and other organs. Early treatment will prevent clinical disease and population-based screening for HH has been advocated. However, the benefit of screening depends on the morbidity of HH. We have compared the morbidity in HH persons detected by screening with the morbidity in the rest of the population.</p> <p>METHODS: All inhabitants 20 years or older in a Norwegian county (94,191 persons) were invited to participate in a health survey programme. Of 65,717 participating persons, a blood specimen for transferrin saturation was obtained from 65,238. After repeated laboratory testing and clinical examination, 269 persons were found to have phenotypic HH, while 297 had genotypic HH (the C282/C282Y mutation). Using self-reported data, clinical examinations and analysis of non-fasting blood samples, the morbidity in phenotypic and genotypic HH persons was compared with the morbidity in the rest of the population. All data were collected before subjects were diagnosed with HH, and all comparisons were corrected for age and gender.</p> <p>RESULTS: Compared to control persons, phenotypic and genotypic HH men and women had a higher score on 1 of 17 questions dealing with joint complaints. Phenotypic and genotypic HH women below 50 years of age had a higher prevalence of hypothyroidism (15.2% and 12.5%, respectively, compared to 3.0% in the control population). Phenotypic HH women below 50 years of age had higher diastolic blood pressure than control women. Phenotypic HH men above 50 years of age and genotypic HH men scored lower than control men on a compound myocardial infarction risk score variable, in part due to lower serum cholesterol concentration. Fewer phenotypic HH men above 50 years of age reported having angina pectoris. Otherwise, the health of phenotypic and genotypic HH persons was not different from the health of control persons.</p> <p>CONCLUSION: When corrected for age and gender, the morbidity in persons with screening-detected HH was not very different from the morbidity in the control group, indicating that population-based screening may not be as beneficial as anticipated.</p>  
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  Notes HUNT_ID:258. HUNT2 Approved no  
  Call Number Serial 257  
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Author Asberg A, Hveem K, Thorstensen K, Ellekjaer E, Kannelonning K, Fjosne U, Halvorsen TB, Smethurst HBG, Sagen E, Bjerve KS   
  Title Screening for hemochromatosis: High prevalence and low morbidity in an unselected population of 65,238 persons. Type Journal Article
  Year 2001 Publication Scand J Gastroenterol 2001 Abbreviated Journal  
  Volume 10 Issue Pages 1108-5.  
  Keywords HUNT2  
  Abstract <h3>Background:</h3> <p>Hereditary hemochromatosis (HH) is a common genetic disease leading to accumulation of iron in several organs, most notably the liver. The C282Y/C282Y mutation in the HFE gene is found in most cases. In order to prevent clinical disease and to study the cost and feasibility of screening, a large population was screened.</p> <h3>Methods:</h3> <p>In a Norwegian county, all inhabitants 20 years or older were invited to participate in a population-based health survey programme. Screening for HH was one of several subprojects. Blood samples were obtained from 65,238 persons. Subjects with high serum transerrin saturation in two tests and high serum ferritin were clinically evaluated for HH. All subjects with high serum transferrin saturation in two tests were offered genotyping.</p> <h3>Results:</h3> <p>HH was newly diagnosed in 92 women and 177 men. Phlebotomy treatment was performed in 64 women and 152 men. Severe organ damage (liver cirrhosis) was ascertained in only 4 men. We found no correlation between serum ferritin and age. The estimated cost was US$ 1.6 per subject screened and US$ 390 per newly discovered HH subject. The estimated prevalence of phenotypical HH not previously known was 0.34% in women and 0.68% in men. The prevalence of the C282Y/C282Y mutation was at least 0.68%.</p> <h3>Conclusion:</h3> <p>Large-scale screening for HH can be performed at a relatively low cost if combined with a health survey programme. The yield in terms of newly discovered cases is considerable, but few cases were found seriously ill. Better knowledge of the natural courses of HH is necessary if we are to be able to estimate the cost-effectiveness of large-scale screening.</p>  
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  Notes HUNT_ID:189. HUNT2 Approved no  
  Call Number Serial 188  
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Author Asberg A, Thorstensen K, Hveem K, Bjerve KS   
  Title Hereditary hemochromatosis: the clinical significance of the S65C mutation. Type Journal Article
  Year 2002 Publication Genet Test 2002 Abbreviated Journal  
  Volume 6(1) Issue Pages 59-62  
  Keywords HUNT2  
  Abstract <p>Hereditary hemochromatosis (HH) is a common genetic disease with iron overload in certain organs, especially the liver. Most cases are homozygous for the C282Y mutation in the HFE gene; a few are C282Y heterozygous, compound C282Y/H63D heterozygous, or have no known mutation. A third mutation, S65C, has been associated with HH, but this finding is disputed. We have studied the clinical significance of various genotypes with the S65C mutation. In a population-based screening for HH in 65,238 persons, 613 had high serum transferrin saturation in two blood samples and were invited for HFE genotyping. In 556 persons with complete data sets, we studied the serum ferritin concentration and the risk of being diagnosed with phenotypic HH in the various genotypic groups. The phenotypic diagnosis was given without knowing the genotypic result. Except for the C282Y homozygotes, no differences in median serum ferritin concentrations were found between the various genotypic groups. However, the C282Y/S65C compound heterozygous group had a higher risk of being diagnosed with phenotypic HH than the wild-type group, as did the C282Y homozygous and the C282Y/H63D compound heterozygous groups. When combined with the C282Y mutation, the S65C mutation is associated with an increased risk of being diagnosed with phenotypic HH.</p>  
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  Notes HUNT_ID:260. HUNT2 Approved no  
  Call Number Serial 259  
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