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Author Asberg, A.N.; Stovner, L.J.; Zwart, J.-A.; Winsvold, B.S.; Heuch, I.; Hagen, K. url  doi
  Title Migraine as a predictor of mortality: The HUNT study Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords Headache; general population; migraine; mortality; HUNT2  
  Abstract BACKGROUND: There is conflicting evidence for the association between migraine and increased mortality risk. The aim of this study was to investigate the relationship between migraine and non-migrainous headache, and all-cause mortality and cardiovascular mortality. METHODS: In this prospective population-based cohort study from Norway, we used baseline data from the second Nord-Trondelag Health Survey (HUNT2), performed between 1995 and 1997 in the County of Nord-Trondelag. These data were linked with a comprehensive mortality database with follow-up through the year 2011. A total of 51,853 (56% of invited) people were categorized based on their answers to the headache questions in HUNT2 (headache free, migraine or non-migrainous headache). Hazard ratios (HRs) of mortality during a mean of 14.1 years of follow-up were estimated using Cox regression. RESULTS: During the follow-up period 9408 died, 4321 of these from cardiovascular causes. There was no difference in all-cause mortality between individuals with migraine and non-migrainous headache compared to those without headache or between headache status and mortality by cardiovascular disease. There was, however, among men with migraine without aura a reduced risk of death by cardiovascular diseases (HR 0.72, 95% confidence interval 0.56-0.93). This relationship was not evident in women. CONCLUSION: In this large, prospective cohort study there was no evidence for a higher all-cause mortality or cardiovascular mortality among individuals with migraine.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian Advisory Unit of Headache, St Olavs Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26115666 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1712  
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Author Blaauw, B.A.; Dyb, G.; Hagen, K.; Holmen, T.L.; Linde, M.; Wentzel-Larsen, T.; Zwart, J.-A. url  doi
  Title Anxiety, depression and behavioral problems among adolescents with recurrent headache: the Young-HUNT study Type Journal Article
  Year 2014 Publication The Journal of Headache and Pain Abbreviated Journal J Headache Pain  
  Volume 15 Issue 1 Pages 38  
  Keywords HUNT2; Young Adult; Young-HUNT; Young-HUNT1; headache; depression; anxiety; behavioral problems  
  Abstract BACKGROUND: It is well documented that both anxiety and depression are associated with headache, but there is limited knowledge regarding the relation between recurrent primary headaches and symptoms of anxiety and depression as well as behavioral problems among adolescents. Assessment of co-morbid disorders is important in order to improve the management of adolescents with recurrent headaches. Thus the main purpose of the present study was to assess the relationship of recurrent headache with anxiety and depressive symptoms and behavioral problems in a large population based cross-sectional survey among adolescents in Norway. METHODS: A cross-sectional, population-based study was conducted in Norway from 1995 to 1997 (Young-HUNT1). In Young-HUNT1, 4872 adolescents aged 12 to 17 years were interviewed about their headache complaints and completed a comprehensive questionnaire that included assessment of symptoms of anxiety and depression and behavioral problems, i.e. conduct and attention difficulties. RESULTS: In adjusted multivariate analyses among adolescents aged 12-14 years, recurrent headache was associated with symptoms of anxiety and depression (OR: 2.05, 95% CI: 1.61-2.61, p < 0.001), but not with behavioral problems. A significant association with anxiety and depressive symptoms was evident for all headache categories; i.e. migraine, tension-type headache and non-classifiable headache. Among adolescents aged 15-17 years there was a significant association between recurrent headache and symptoms of anxiety and depression (OR: 1.64, 95% CI: 1.39-1.93, p < 0,001) and attention difficulties (OR: 1.25, 95% CI: 1.09-1.44, p =0.001). For migraine there was a significant association with both anxiety and depressive symptoms and attention difficulties, while tension-type headache was significantly associated only with symptoms of anxiety and depression. Non-classifiable headache was associated with attention difficulties and conduct difficulties, but not with anxiety and depressive symptoms. Headache frequency was significantly associated with increasing symptoms scores for anxiety and depressive symptoms as well as attention difficulties, evident for both age groups. CONCLUSIONS: The results from the present study indicate that both anxiety and depressive symptoms and behavioral problems are associated with recurrent headache, and should accordingly be considered a part of the clinical assessment of children and adolescents with headache. Identification of these associated factors and addressing them in interventions may improve headache management.  
  Address Department of Neurology, Vestfold Hospital, Tonsberg, Norway. britaj@mac.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1129-2369 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24925252; PMC4062897 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1620  
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Author Borte, S.; Winsvold, B.S.; Stensland, S.O.; Smastuen, M.C.; Zwart, J.-A. url  doi
  Title The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study Type Journal Article
  Year 2017 Publication PloS one Abbreviated Journal PLoS One  
  Volume 12 Issue 4 Pages e0175908  
  Keywords Adult; Birth Weight; Female; Fetal Growth Retardation/epidemiology/*etiology; Gestational Age; Health Surveys; Humans; Infant, Newborn; Logistic Models; Male; Migraine Disorders/complications/*diagnosis/epidemiology; Norway/epidemiology; Odds Ratio; Pregnancy; Registries; Risk Factors; Tension-Type Headache/complications/*diagnosis/epidemiology; Young Adult  
  Abstract BACKGROUND: There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults. METHODS: The population-based Nord-Trondelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19-41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10th-90th percentile), small for gestational age (SGA, 3rd-10th percentile) or very small for gestational age (VSGA, < 3rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth. RESULTS: The effect of growth restriction on migraine was modified by sex, with a significant association in males (p<0.001), but not in females (p = 0.20). In particular, males born VSGA were at increased risk of developing migraine (OR 2.73, 95% CI 1.63-4.58, p<0.001), with an intermediate risk among those born SGA (OR 1.50, 95% CI 0.96-2.35, p = 0.08) compared to those born AGA. There was no significant association between growth restriction and frequent TTH (p = 0.051). CONCLUSION: Growth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable.  
  Address Department of Neurology, Oslo University Hospital, Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28410431; PMCID:PMC5391957 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1885  
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Author Fagernaes, C.F.; Heuch, I.; Zwart, J.-A.; Winsvold, B.S.; Linde, M.; Hagen, K. url  doi
  Title Blood pressure as a risk factor for headache and migraine: a prospective population-based study Type Journal Article
  Year 2014 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume Issue Pages  
  Keywords blood pressure; headache; hypertension-associated hypalgesia; migraine; HUNT2; HUNT3  
  Abstract BACKGROUND AND PURPOSE: During the past decade, several population-based studies have found an inverse association between blood pressure (BP) and headache. However, most of them have a cross-sectional design or lack a validated definition of a headache-free population at baseline. Therefore, additional population-based studies using a clearly defined headache-free population and a prospective design are warranted. METHODS: Data from two large epidemiological studies, the Nord-Trondelag Health Survey 1995-1997 (HUNT 2) and 2006-2008 (HUNT 3), were used to evaluate the association between BP (systolic, diastolic and pulse pressure) at baseline and headache (migraine and tension type headache) at follow-up. RESULTS: An inverse relationship was found between all three BP measures at baseline in HUNT 2 and any headache in HUNT 3, more evident for systolic BP [odds ratio (OR) 0.90 per 10 mmHg increase in systolic BP, 95% confidence interval (CI) 0.87-0.93, P < 0.001] and pulse pressure (OR 0.84 per 10 mmHg increase in pulse pressure, 95% CI 0.80-0.89, P < 0.001) than for diastolic BP (OR 0.92 per 10 mmHg increase in diastolic BP, 95% CI 0.87-1.00, P = 0.036). The most robust finding, evident for both sexes, was that increased pulse pressure was linked to decreased prevalence of both migraine and tension type headache. CONCLUSION: An inverse relationship between BP and subsequent development of headache was confirmed in this large-scale population-based cohort study. Nevertheless, further research is needed to investigate the underlying mechanisms explaining these findings.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25155744 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1628  
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Author Fagernaes, C.F.; Heuch, I.; Zwart, J.A.; Winsvold, B.S.; Linde, M.; Hagen, K.   
  Title Blood pressure as a risk factor for headache and migraine: a prospective population-based study Type Journal Article
  Year 2015 Publication Eur J Neurol Abbreviated Journal European journal of neurology  
  Volume 22 Issue 1 Pages 156-62,  
  Keywords Adult; Aged; Blood Pressure/*physiology; Blood Pressure Determination; Female; Humans; Male; Middle Aged; Migraine Disorders/*epidemiology; Norway/epidemiology; Prevalence; Prospective Studies; Risk Factors; Tension-Type Headache/*epidemiology; HUNT2; HUNT3  
  Abstract BACKGROUND AND PURPOSE: During the past decade, several population-based studies have found an inverse association between blood pressure (BP) and headache. However, most of them have a cross-sectional design or lack a validated definition of a headache-free population at baseline. Therefore, additional population-based studies using a clearly defined headache-free population and a prospective design are warranted. METHODS: Data from two large epidemiological studies, the Nord-Trondelag Health Survey 1995-1997 (HUNT 2) and 2006-2008 (HUNT 3), were used to evaluate the association between BP (systolic, diastolic and pulse pressure) at baseline and headache (migraine and tension type headache) at follow-up. RESULTS: An inverse relationship was found between all three BP measures at baseline in HUNT 2 and any headache in HUNT 3, more evident for systolic BP [odds ratio (OR) 0.90 per 10 mmHg increase in systolic BP, 95% confidence interval (CI) 0.87-0.93, P  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Fagernaes2015 Serial 1807  
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Author Hagen, K.; Asvold, B.O.; Midthjell, K.; Stovner, L.J.; Zwart, J.-A.; Linde, M. url  doi
  Title Inverse relationship between type 1 diabetes mellitus and migraine. Data from the Nord-Trondelag Health Surveys 1995-1997 and 2006-2008 Type Journal Article
  Year 2018 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 38 Issue 3 Pages 417-426  
  Keywords *Epidemiology; *diabetes mellitus; *headache; *migraine  
  Abstract Aims The aim of this cross-sectional population-based study was to investigate the associations between migraine and type 1 and type 2 diabetes mellitus (DM). Methods We used data from the second (1995-1997) and third survey (2006-2008) in the Nord-Trondelag Health Study. Analyses were made for the 26,121 participants (30-97 years of age, median 58.3 years) with known headache and DM status in both surveys, and for the 39,584 participants in the third survey (20-97 years, median 54.1 years). The diagnosis of migraine was given to those who fulfilled the questionnaire-based migraine diagnosis in the second and/or third survey. Associations were assessed using multiple logistic regression, estimating prevalence odds ratio (OR) with 95% confidence intervals (CIs). Results In the multivariate analysis of the 26,121 participants in both surveys, adjusting for age, gender, years of education, and smoking, classical type 1 DM (n = 81) was associated with a lower prevalence of any headache (OR = 0.55, 95% CI 0.34-0.88),and migraine (OR = 0.47, 95% CI 0.26-0.96) compared to those without DM (n = 24,779). Correspondingly, the merged group of classical type 1 DM and latent autoimmune diabetes of adults (LADA) (n = 153) were less likely to have migraine (OR = 0.53, 95% CI 0.31-0.91). Similarly, an inverse relationship between type 1 DM and migraine was found in analyses of 39,584 participants in the third survey. No clear association was found between headache and type 2 DM. Conclusions In this cross-sectional population-based study of mainly middle-aged participants, type 1 DM was inversely associated with headache, in particular migraine.  
  Address 2 Norwegian Advisory Unit on Headache, St. Olavs Hospital, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28114807 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2087  
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Author Hagen, K.; Linde, M.; Steiner, T.J.; Stovner, L.J.; Zwart, J.-A. url  doi
  Title Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trondelag Health Studies Type Journal Article
  Year 2012 Publication Pain Abbreviated Journal Pain  
  Volume 153 Issue 1 Pages 56-61  
  Keywords Adult; Aged; Analgesics/*adverse effects; Female; Follow-Up Studies; Headache Disorders, Secondary/chemically induced/*epidemiology; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Norway/epidemiology; Prevalence; Risk Factors  
  Abstract Medication-overuse headache (MOH) is relatively common, but its incidence has not been calculated and there are no prospective population-based studies that have evaluated risk factors for developing MOH. The aim of this study was to estimate incidences of and identify risk factors for developing chronic daily headache (CDH) and MOH. This longitudinal population-based cohort study used data from the Nord-Trondelag Health Surveys performed in 1995-1997 and 2006-2008. Among the 51,383 participants at baseline, 41,766 were eligible approximately 11 years later. There were 26,197 participants (responder rate 63%), among whom 25,596 did not report CDH at baseline in 1995-1997. Of these, 201 (0.8%) had MOH and 246 (1.0%) had CDH without medication overuse (CDHwoO) 11 years later. The incidence of MOH was 0.72 per 1000 person-years (95% confidence interval 0.62-0.81). In the multivariate analyses, a 5-fold risk for developing MOH was found among individuals who at baseline reported regular use of tranquilizers [odds ratio 5.2 (3.0-9.0)] or who had a combination of chronic musculoskeletal complaints, gastrointestinal complaints, and Hospital Anxiety and Depression Scale score >/= 11 [odds ratio 4.7 (2.4-9.0)]. Smoking and physical inactivity more than doubled the risk of MOH. In contrast, these factors did not increase the risk of CDHwoO. In this large population-based 11-year follow-up study, several risk factors for MOH did not increase the risk for CDHwoO, suggesting these are pathogenetically distinct. If the noted associations are causal, more focus on comorbid condition, physical activity, and use of tobacco and tranquilizers may limit the development of MOH.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0304-3959 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22018971 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1527  
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Author Hagen, K.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title The bidirectional relationship between headache and chronic musculoskeletal complaints: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2012 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume 19 Issue 11 Pages 1447-1454  
  Keywords Cohort Studies; Female; Follow-Up Studies; Headache Disorders/*complications/*epidemiology; Humans; Male; Middle Aged; Musculoskeletal Pain/*complications/*epidemiology; Questionnaires  
  Abstract BACKGROUND AND PURPOSE: Chronic daily headache (CDH) and chronic musculoskeletal complaints (CMSCs) are associated disorders, but whether there is a causal relationship between them is unclear. OBJECTIVE: To determine whether CMSCs are associated with the subsequent development of CDH and vice versa. METHODS: This longitudinal population-based cohort study used data from two consecutive surveys in the Nord-Trondelag Health Study (HUNT 2 and 3) performed in 1995-1997 and 2006-2008. Amongst the 51 383 participants aged >/= 20 years at baseline, 41 766 were eligible approximately 11 years later. Of these, 26 197 (63%) completed the questions regarding headache and CMSCs in HUNT 3. RESULTS: A bidirectional relationship was found between headache and CMSCs. In the multivariate analyses adjusting for known potential confounders, a nearly two fold risk (OR 1.8; 95% CI 1.5-2.3) for developing CDH was found for those with CMSCs at baseline. Vice versa, a similarly elevated risk of CMSCs (OR 1.8; 95% CI 1.2-2.6), and even higher risk of chronic widespread MSCs (OR 2.7; 95% CI 1.6-4.7), was found at follow-up amongst those with CDH at baseline. CONCLUSION: CMSCs predispose to CDH and CDH predisposes to CMSCs 11 years later. This may have relevance to understanding the pathophysiology of these disorders. CMSCs should be treated not only to relieve them but also to prevent the development of CDH, and vice versa.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22519547 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1528  
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Author Hagen, K.; Stordal, E.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title Headache as a risk factor for dementia: A prospective population-based study Type Journal Article
  Year 2013 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords Alzheimer’s disease; headache; migraine; vascular dementia  
  Abstract BACKGROUND: Headache has not been established as a risk factor for dementia. The aim of this study was to determine whether any headache was associated with subsequent development of vascular dementia (VaD), Alzheimer's disease (AD) or other types of dementia. METHODS: This prospective population-based cohort study used baseline data from the Nord-Trondelag Health Study (HUNT 2) performed during 1995-1997 and, from the same Norwegian county, a register of cases diagnosed with dementia during 1997-2010. Participants aged >/=20 years who responded to headache questions in HUNT 2 were categorized (headache free; with any headache; with migraine; with nonmigrainous headache). Hazard ratios (HRs) for later inclusion in the dementia register were estimated using Cox regression analysis. RESULTS: Of 51,383 participants providing headache data in HUNT 2, 378 appeared in the dementia register during the follow-up period. Compared to those who were headache free, participants with any headache had increased risk of VaD ( N = 63) (multivariate-adjusted HR = 2.3, 95% CI 1.4-3.8, P = 0.002) and of mixed dementia (VaD and AD ( N = 52)) (adjusted HR = 2.0, 95% CI 1.1-3.5, P = 0.018). There was no association between any headache and later development of AD ( N = 180). CONCLUSION: In this prospective population-based cohort study, any headache was a risk factor for development of VaD.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24265286 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1447  
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Author Hagen, K.; Stordal, E.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title Headache as a risk factor for dementia: a prospective population-based study Type Journal Article
  Year 2014 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 34 Issue 5 Pages 327-335  
  Keywords Alzheimer’s disease; headache; migraine; vascular dementia  
  Abstract BACKGROUND: Headache has not been established as a risk factor for dementia. The aim of this study was to determine whether any headache was associated with subsequent development of vascular dementia (VaD), Alzheimer's disease (AD) or other types of dementia. METHODS: This prospective population-based cohort study used baseline data from the Nord-Trondelag Health Study (HUNT 2) performed during 1995-1997 and, from the same Norwegian county, a register of cases diagnosed with dementia during 1997-2010. Participants aged >/=20 years who responded to headache questions in HUNT 2 were categorized (headache free; with any headache; with migraine; with non-migrainous headache). Hazard ratios (HRs) for later inclusion in the dementia register were estimated using Cox regression analysis. RESULTS: Of 51,383 participants providing headache data in HUNT 2, 378 appeared in the dementia register during the follow-up period. Compared to those who were headache free, participants with any headache had increased risk of VaD ( N = 63) (multivariate-adjusted HR = 2.3, 95% CI 1.4-3.8, P = 0.002) and of mixed dementia (VaD and AD ( N = 52)) (adjusted HR = 2.0, 95% CI 1.1-3.5, P = 0.018). There was no association between any headache and later development of AD ( N = 180). CONCLUSION: In this prospective population-based cohort study, any headache was a risk factor for development of VaD.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24265286 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1598  
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Author Hansen, A.G.; Stovner, L.J.; Hagen, K.; Helvik, A.-S.; Thorstensen, W.M.; Nordgard, S.; Bugten, V.; Eggesbo, H.B. url  doi
  Title Paranasal sinus opacification in headache sufferers: A population-based imaging study (the HUNT study-MRI) Type Journal Article
  Year 2017 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 37 Issue 6 Pages 509-516  
  Keywords Paranasal sinuses; headache; magnetic resonance imaging; migraine; opacification; sinus headache; tension headache  
  Abstract Background The association between headache and paranasal sinus disease is still unclear. Because of symptom overlap, the two conditions are not easily studied on the basis of symptoms alone. The aim of the present study was to investigate whether paranasal sinus opacification on magnetic resonance imaging (MRI) was associated with migraine, tension-type headache (TTH) or unclassified headache. Methods This was a cross-sectional study of 844 randomly selected participants (442 women, age range 50-65 years, mean age 57.7 years). Based on 14 headache questions, participants were allocated to four mutually exclusive groups: migraine, TTH, unclassified headache or headache free. On MRI, opacifications as mucosal thickening, polyps/retention cysts and fluid in the five paired sinuses were measured and recorded if >/=1 mm. For each participant, opacification thickness was summed for each sinus and, in addition, a total sum of all sinuses was calculated. Opacification in each sinus was compared between headache-free participants and the headache groups using non-parametric tests, and the total sum was compared by logistical regression. Results No significant association was found between paranasal sinus opacification and headache in general, nor when headache was differentiated into migraine, TTH and unclassified headache. This was also true in separate analyses of mucosal thickening and fluid and of opacification from each paranasal sinus. Conclusion Migraine, TTH and unclassified headache were found not to be associated with an increased degree of paranasal sinus opacification at MRI.  
  Address 5 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27215544 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1921  
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Author Honningsvag, L.-M.; Hagen, K.; Haberg, A.; Stovner, L.J.; Linde, M. url  doi
  Title Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI) Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords HUNT3; Health survey; cerebral infarction; cysts; malformations; migraine; pathology; tension-type headache; unclassified headache; white matter  
  Abstract BACKGROUND: Most studies on intracranial abnormalities among headache sufferers were performed in selected clinical populations. The aim of this study was to evaluate the relationship between intracranial abnormalities and headache among middle-aged adults in the general population. METHODS: Participants in a large epidemiological study (the HUNT 3 study; 2006-2008) who answered a headache questionnaire and participated in a population-based imaging study of the head (HUNT MRI; 2007-2009) were included (n = 864; age, 50-65 at enrollment). Based on the responses to the HUNT 3 questionnaire, respondents were categorized as having migraine, tension-type headache, or unclassified headache. Logistic regression was used to compare the occurrence of intracranial abnormalities between groups. RESULTS: Intracranial abnormalities were more common in headache sufferers than in headache-free individuals (29% vs. 22%, respectively; p = 0.041). Adjusted multivariate analyses revealed that those with tension-type headache had higher odds of having minor abnormalities (odds ratio, 2.13; 95% confidence interval = 1.18-3.85). This association disappeared when those with only white matter hyperintensities were removed from the analysis. CONCLUSIONS: Headache sufferers had increased odds of minor intracranial abnormalities. The increased odds were primarily related to the presence of white matter hyperintensities.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian Advisory Unit on Headache, St. Olavs University Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25896482 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1691  
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Author Husoy, A.K.; Indergaard, M.K.; Honningsvag, L.-M.; Haberg, A.K.; Hagen, K.; Linde, M.; Garseth, M.; Stovner, L.J. url  doi
  Title Perivascular spaces and headache: A population-based imaging study (HUNT-MRI) Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords HUNT1; HUNT2; HUNT3; Virchow-Robin spaces; epidemiology; headache; magnetic resonance imaging; migraine; population-based  
  Abstract BACKGROUND: In four previous clinic-based MRI studies headache sufferers (in particular migraineurs) had more perivascular spaces (PVS) than individuals who were headache-free. METHODS: The present study was part of a large longitudinal, epidemiological study (Nord-Trondelag Health Survey (HUNT)). The 1006 participants, age 50-65 years at inclusion, had participated in all previous HUNT surveys (1-3), and been randomly selected to a population-based imaging study of the head (HUNT-MRI, 2007-2009). The number of visible PVS in the basal ganglia (BG) and hemispheric white matter (HWM) was compared in headache sufferers (migraine with and without aura, non-migrainous headache) and people who were headache-free. RESULTS: The results showed in general small differences between headache sufferers and headache-free participants. In the cross-sectional analysis migraineurs without aura had fewer PVS than headache-free individuals in BG (OR = 0.84, 95% CI = 0.76--0.94, p value = 0.003) and in BG and HWM together (OR = 0.97, 95% CI = 0.95-1.00, p value = 0.046). No difference between long-term headache sufferers and long-term headache-free individuals with regard to number of PVS was found. DISCUSSION: In contrast to previous studies, the present large, blinded, population-based study showed no increase in number of dilated PVS among headache sufferers. Fewer PVS among those with migraine without aura may be a spurious finding.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian National Headache Centre, St Olavs University Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26024925 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1699  
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Author Husoy, A.K.; Indergaard, M.K.; Honningsvag, L.M.; Haberg, A.K.; Hagen, K.; Linde, M.; Garseth, M.; Stovner, L.J. url  doi
  Title Perivascular spaces and headache: A population-based imaging study (HUNT-MRI) Type Journal Article
  Year 2016 Publication Cephalalgia Abbreviated Journal Cephalalgia  
  Volume 36 Issue 3 Pages 232-239  
  Keywords HUNT1; HUNT2; HUNT3; Virchow-Robin spaces; epidemiology; headache; magnetic resonance imaging; migraine; population-based  
  Abstract BACKGROUND: In four previous clinic-based MRI studies headache sufferers (in particular migraineurs) had more perivascular spaces (PVS) than individuals who were headache-free. METHODS: The present study was part of a large longitudinal, epidemiological study (Nord-Trondelag Health Survey (HUNT)). The 1006 participants, age 50-65 years at inclusion, had participated in all previous HUNT surveys (1-3), and been randomly selected to a population-based imaging study of the head (HUNT-MRI, 2007-2009). The number of visible PVS in the basal ganglia (BG) and hemispheric white matter (HWM) was compared in headache sufferers (migraine with and without aura, non-migrainous headache) and people who were headache-free. RESULTS: The results showed in general small differences between headache sufferers and headache-free participants. In the cross-sectional analysis migraineurs without aura had fewer PVS than headache-free individuals in BG (OR = 0.84, 95% CI = 0.76--0.94, p value = 0.003) and in BG and HWM together (OR = 0.97, 95% CI = 0.95-1.00, p value = 0.046). No difference between long-term headache sufferers and long-term headache-free individuals with regard to number of PVS was found. DISCUSSION: In contrast to previous studies, the present large, blinded, population-based study showed no increase in number of dilated PVS among headache sufferers. Fewer PVS among those with migraine without aura may be a spurious finding.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Norway ahusoy@gmail.com. Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Husoy, Andreas KattemIndergaard, Marit KristinaHonningsvag, Lasse-MariusHaberg, Asta KHagen, KnutLinde, MattiasGarseth, MariStovner, Lars JacobengResearch Support, Non-U.S. Gov'tEngland2015/05/31 06:00Cephalalgia. 2016 Mar;36(3):232-9. doi: 10.1177/0333102415587691. Epub 2015 May 29. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Husoy2016 Serial 1753  
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Author Jacobsena, B.A.; Dyb, G.; Hagen, K.; Stovner, L.J.; Holmen, T.L.; Zwart, J.-A. url  doi
  Title The Nord-Trondelag Health Study shows increased prevalence of primary recurrent headaches among adolescents over a four-year period Type Journal Article
  Year 2018 Publication Scandinavian Journal of Pain Abbreviated Journal Scand J Pain  
  Volume 2 Issue 3 Pages 148-152  
  Keywords Adolescents; Epidemiology; Headache; Migraine; Prevalence; Tension-type headache  
  Abstract Objective Earlier epidemiological studies have shown that headaches are frequent among adolescents, especially girls. In particular, recurrent primary headache disorders such as migraine and tension-type headaches are common complaints in this age group. Headaches are increasingly being recognized as a significant health problem in adolescents and can lead to significant disabilities by affecting their lives, their school performance and their social lives. The aim of this study was to compare the prevalence of primary headaches among adolescents aged 16-20 years in Norway in two periods. Very few replicate studies have re-evaluated the prevalence of primary headaches in this age range and it is uncertain whether the prevalence is increasing. Methods Two cross-sectional, population-based studies were conducted in Norway from 1995 to 1997 (Young-HUNT 1) and from 1999 to 2001 (Young-HUNT 2). In Young-HUNT 1, 2594 adolescents in 2nd and 3rd grade in upper secondary school (aged 16-20 years) completed a comprehensive questionnaire including one question regarding headache during the last 12 months. In addition, 1730 of the students were interviewed about their headache complaints. In Young-HUNT 2, 2373 adolescents aged 16-20 years completed the same questionnaire and 1655 were interviewed in the same way as the earlier survey. The interviews were performed by trained nurses, and respondents were asked if they had experienced recurrent headache during the last year. If so, the headache was classified as migraine (MI), tensiontype headache (TTH) or non-classifiable headache (NCH). Headache frequency during the past year was recorded according to the following categories: Less than 1 day per month (less than monthly), 1-3 days per month (monthly), 1-5 days per week (weekly), or more than 5 days per week (daily). Results The participation rate was 88% in Young-HUNT 1 and 81% in Young-HUNT 2. The overall prevalence of having had headaches during the last 12 months did not change significantly (79.4% versus 77.5%; OR: 0.89, 95%CI: 0.79-1.02, p = 0.09), whereas the prevalence of recurrent headaches increased from 30.3% in Young-HUNT 1 to 35.4% in Young-HUNT 2 (OR: 1.26, 95%CI: 1.09-1.46, p = 0.002). The prevalence of tension-type headache changed significantly from 19.0% to 21.9% (OR: 1.20, 95%CI: 1.02-1.42, p = 0.03). Also the prevalence of migraine tended to increase (7.5% versus 8.7%, OR: 1.18, 95%CI: 0.92-1.52, p = 0.18). The overall frequency of recurrent headache changed towards more monthly and less weekly headache. Conclusions This is the first large-scale population-based study among adolescents in Norway assessing changes in the prevalence of primary headaches over a four-year period of time. The overall prevalence of recurrent headaches increased significantly from Young-HUNT 1 to Young-HUNT 2. An increase was seen in all types of recurrent headaches and was significant for tension-type headache. Implications Earlier follow-up studies have examined changes in prevalence of recurrent headaches in young age, but the results are diverging. Our findings support the impression that the prevalence of recurrent headache among adolescents is increasing, and underlines the need for prospective designed studies with emphasis on prognosis and etiological factors.  
  Address National Centre for Spinal Disorders, St. Olavs Hospital, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1877-8860 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29913741 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2114  
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Author Jarholm, J.A.; Faiz, K.W.; Nysted, T.; Zarnovicky, S.; Kristoffersen, E.S. url  doi
  Title Orbital Pain, Ophthalmoplegia, and Oligoclonal Bands in the Cerebrospinal Fluid: A Case Report of Tolosa-Hunt Syndrome Type Journal Article
  Year 2018 Publication Headache Abbreviated Journal Headache  
  Volume 58 Issue 5 Pages 758-760  
  Keywords International Classification of Headache Disorders; diplopia; facial pain; headache; painful cranial neuropathies  
  Abstract  
  Address Department of General Practice, Helsam, University of Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0017-8748 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29516491 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2115  
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Author Johnsen, M.B.; Winsvold, B.S.; Borte, S.; Vie, G.A.; Pedersen, L.M.; Storheim, K.; Skorpen, F.; Hagen, K.; Bjorngaard, J.H.; Asvold, B.O.; Zwart, J.A. url  doi
  Title The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study Type Journal Article
  Year 2018 Publication European Journal of Neurology Abbreviated Journal Eur J Neurol  
  Volume 25 Issue 9 Pages 1148-e102  
  Keywords *epidemiology; *genetic variants; *headache; *migraine; *smoking  
  Abstract BACKGROUND AND PURPOSE: Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD: A total of 58 316 participants from the Nord-Trondelag Health (HUNT) study with information on headache status were genotyped for the rs1051730 C>T single-nucleotide polymorphism (SNP). The SNP was used as an instrument for smoking intensity in a Mendelian randomization analysis. The association between rs1051730 T alleles and headache was estimated by odds ratios with 95% confidence intervals. Additionally, the association between the SNP and migraine or non-migrainous headache versus no headache was investigated. All analyses were adjusted for age and sex. RESULTS: There was no strong evidence that the rs1051730 T allele was associated with headache in ever smokers (odds ratio 0.99, 95% confidence interval 0.95-1.02). Similarly, there was no association between the rs1051730 T allele and migraine or non-migrainous headache versus no headache. CONCLUSION: The findings from this study do not support that there is a strong causal relationship between smoking intensity and any type of headache. Larger Mendelian randomization studies are required to examine whether higher smoking quantity can lead to a moderate increase in the risk of headache subtypes.  
  Address Department of Neurology, Oslo University Hospital, Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29747220 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2106  
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Author Linde, M.; Langnes, H.A.; Hagen, K.; Bergh, K.; Stovner, L.J. url  doi
  Title No increase in headache after previous intracranial infections: a historical cohort study (HUNT) Type Journal Article
  Year 2012 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume 19 Issue 2 Pages 324-331  
  Keywords Adult; Aged; Central Nervous System Infections/*complications; Cohort Studies; Female; Headache/diagnosis/*epidemiology/*etiology; Health Surveys; Humans; Longitudinal Studies; Male; Middle Aged; Prevalence; Questionnaires  
  Abstract BACKGROUND AND PURPOSE: Despite the absence of robust scientific evidence, it is today generally accepted that the acute headache typical for intracranial infections can develop into permanent headache complaints. This widespread concept was explored in the first, large, longitudinal, population-based study. METHODS: Data on confirmed exposure to intracranial infections amongst all adult inhabitants in a geographical area during a 20-year period were assembled from hospital records. Surviving individuals were later invited to the third Nord-Trondelag Health Survey (HUNT 3), where 39,690 (42%) of 94,194 invited inhabitants aged >/=20 years responded to a validated headache questionnaire. Using logistic regression, the 1-year prevalence of headache and its subtypes according to the diagnostic criteria of the International Headache Society was assessed and compared between those with and without previous confirmed intracranial infection. Age and sex were used as covariates. RESULTS: Overall, 43 participants were identified with earlier intracranial infection, whereof three had more than one infection: bacterial meningitis (n=19), lymphocytic meningitis (n=18), encephalitis (n=9), and brain abscess (n=1).The mean interval from infection to participation in HUNT 3 was 11.2 (range 1.5-19.7) years. There was no significant increase in the prevalence of headache (OR 1.10, 95% CI 0.58-2.07), its subtypes (migraine, or tension-type headache), or chronic daily headache (OR 1.85, 95% CI 0.45-7.68) amongst participants with previous intracranial infection compared with the surrounding population. CONCLUSIONS: This study challenges the existence of chronic post-bacterial meningitis headache and does not indicate the presence of other long-term headaches induced by intracranial infection.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. mattias.linde@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21951375 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1545  
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Author Nordhaug, L.H.; Hagen, K.; Vik, A.; Stovner, L.J.; Follestad, T.; Pedersen, T.; Gravdahl, G.B.; Linde, M. url  doi
  Title Headache following head injury: a population-based longitudinal cohort study (HUNT) Type Journal Article
  Year 2018 Publication The Journal of Headache and Pain Abbreviated Journal J Headache Pain  
  Volume 19 Issue 1 Pages 8  
  Keywords Adult; Aged; Cohort Studies; Craniocerebral Trauma/*diagnosis/*epidemiology/psychology; Female; Headache/*diagnosis/*epidemiology/psychology; Health Surveys/*trends; Humans; Longitudinal Studies; Male; Middle Aged; *Population Surveillance; Head injury; Headache attributed to head injury; Population-based; Post-traumatic headache; Secondary headache disorders; Traumatic brain injury  
  Abstract BACKGROUND: Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether subjects hospitalized due to a head injury more often developed a new headache or experienced exacerbation of previously reported headache compared to the surrounding population. METHODS: This population-based historical cohort study included headache data from two large epidemiological surveys performed with an 11-year interval. This was linked with data from hospital records on exposure to head injury occurring between the health surveys. Participants in the surveys who had not been hospitalized because of a head injury comprised the control group. The head injuries were classified according to the Head Injury Severity Scale (HISS). Multinomial logistic regression was performed to investigate the association between head injury and new headache or exacerbation of pre-existing headache in a population with known pre-injury headache status, controlling for potential confounders. RESULTS: The exposed group consisted of 294 individuals and the control group of 25,662 individuals. In multivariate analyses, adjusting for age, sex, anxiety, depression, education level, smoking and alcohol use, mild head injury increased the risk of new onset headache suffering (OR 1.74, 95% CI 1.05-2.87), stable headache suffering (OR 1.70, 95% CI 1.15-2.50) and exacerbation of previously reported headache (OR 1.93, 95% CI 1.24-3.02). The reference category was participants without headache in both surveys. CONCLUSION: Individuals hospitalized due to a head injury were more likely to have new onset and worsening of pre-existing headache and persistent headache, compared to the surrounding general population. The results support the entity of the ICHD-3 beta diagnosis “persistent headache attributed to traumatic injury to the head”.  
  Address Norwegian Advisory Unit on Headaches, St. Olavs University Hospital, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1129-2369 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29356960; PMCID:PMC5777966 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2145  
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Author Straete Rottereng, A.K.; Bosnes, O.; Stordal, E.; Zwart, J.A.; Linde, M.; Stovner, L.J.; Hagen, K. url  doi
  Title Headache as a predictor for dementia: The HUNT Study Type Journal Article
  Year 2015 Publication J Headache Pain Abbreviated Journal The journal of headache and pain  
  Volume 16 Issue 1 Pages 89  
  Keywords HUNT2; HUNT3; Aged; Aged, 80 and over; Dementia/*diagnosis/*epidemiology; Female; Headache/*diagnosis/*epidemiology; Health Surveys/*methods; Humans; Longitudinal Studies; Male; Middle Aged; Migraine Disorders/diagnosis/epidemiology; Norway/epidemiology; Population Surveillance/*methods; Predictive Value of Tests  
  Abstract BACKGROUND: The impact of headache on dementia is largely unknown. This study examined the association between headache and dementia using data from a large population-based study. METHODS: This population-based study used data from the Nord-Trondelag Health Surveys performed in 1995-1997 (HUNT2) and 2006-2008 (HUNT3). The reference group (controls) was participants aged >/=55 years who answered the headache questions in HUNT2 and later participated in HUNT3 (n = 15,601). The association with headache status in HUNT2 was investigated in sample of confirmed non-demented elderly evaluated with psychometric tests after HUNT3 (n = 96), and HUNT2 participants later diagnosed with dementia during 1997-2011 (n = 746). The association with headache was evaluated by logistical regression with adjustment for age, gender, level of education, comorbidity, smoking, and anxiety and depression. RESULTS: Any headache was more likely to be reported in HUNT2 among those who later were included in the dementia registry (OR 1.24; 95 % CI 1.04-1.49) compared to the reference group, but less likely among the confirmed non-demented individuals (OR 0.62; 95 % CI 0.39-0.98). This relationship was even stronger for non-migrainous headache, whereas such association was not found for migraine. CONCLUSIONS: Compared to the reference group, individuals with dementia were more likely to report non-previous migrainous headache in HUNT2, whereas a sample of confirmed non-demented were less likely to report previous non-migrainous headache.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.Depart Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Rottereng, Ane Karoline StraeteBosnes, OleStordal, EysteinZwart, John-AnkerLinde, MattiasStovner, Lars JacobHagen, KnutengItaly2015/10/17 06:00J Headache Pain. 2015 Dec;16(1):89. doi: 10.1186/s10194-015-0573-x. Epub 2015 Oct 15. Approved no  
  Call Number HUNT @ maria.stuifbergen @ StraeteRottereng2015 Serial 1864  
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Author Winsvold, B.S.; Palta, P.; Eising, E.; Page, C.M.; van den Maagdenberg, A.M.; Palotie, A.; Zwart, J.-A. url  doi
  Title Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study Type Journal Article
  Year 2018 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 38 Issue 2 Pages 312-322  
  Keywords Adolescent; Adult; Case-Control Studies; CpG Islands/genetics; DNA Methylation/*genetics; Epigenesis, Genetic; Female; Genome-Wide Association Study; Headache Disorders/*genetics; Humans; Retrospective Studies; Young Adult; *Chronic headache; *cohort studies; *epigenetics  
  Abstract Background The biological mechanisms of headache chronification are poorly understood. We aimed to identify changes in DNA methylation associated with the transformation from episodic to chronic headache. Methods Participants were recruited from the population-based Norwegian HUNT Study. Thirty-six female headache patients who transformed from episodic to chronic headache between baseline and follow-up 11 years later were matched against 35 controls with episodic headache. DNA methylation was quantified at 485,000 CpG sites, and changes in methylation level at these sites were compared between cases and controls by linear regression analysis. Data were analyzed in two stages (Stages 1 and 2) and in a combined meta-analysis. Results None of the top 20 CpG sites identified in Stage 1 replicated in Stage 2 after multiple testing correction. In the combined meta-analysis the strongest associated CpG sites were related to SH2D5 and NPTX2, two brain-expressed genes involved in the regulation of synaptic plasticity. Functional enrichment analysis pointed to processes including calcium ion binding and estrogen receptor pathways. Conclusion In this first genome-wide study of DNA methylation in headache chronification several potentially implicated loci and processes were identified. The study exemplifies the use of prospectively collected population cohorts to search for epigenetic mechanisms of disease.  
  Address 2 Institute of Clinical Medicine, University of Oslo, Oslo, Norway  
  Corporate Author International Headache Genetics Consortium Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28103696 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2189  
Permanent link to this record
 

 
Author Winsvold, B.S.; Sandven, I.; Hagen, K.; Linde, M.; Midthjell, K.; Zwart, J.-A. url  doi
  Title Migraine, headache and development of metabolic syndrome: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2013 Publication Pain Abbreviated Journal Pain  
  Volume 154 Issue 8 Pages 1305-1311  
  Keywords Adult; Cardiovascular Diseases/*epidemiology; Cohort Studies; Female; Headache/diagnosis/*epidemiology; Humans; Logistic Models; Male; Metabolic Diseases/diagnosis/*epidemiology; Middle Aged; Migraine Disorders/diagnosis/*epidemiology; Norway/epidemiology; Retrospective Studies; Risk Factors; Young Adult  
  Abstract Migraine with aura is associated with an increased incidence of stroke and cardiovascular disease, but the biological mechanisms are poorly understood. This study examined the incidence of metabolic syndrome and its relationship to migraine with and without aura and to nonmigraine headache. In the population-based the Nord-Trondelag Health Study (HUNT), 19,895 individuals were followed for the development of metabolic syndrome, with a median follow-up time of 11.3 years. Headache diagnoses were based on a validated headache questionnaire, and metabolic syndrome was based on a modified version of the National Cholesterol Education Program's Adult Treatment Panel (ATP) III criteria, using objective anthropometric measurements and blood biochemistry. Using the Poisson regression model, migraine with aura was associated with an increased risk for developing metabolic syndrome. The effect was modified by smoking, with an adjusted incident risk ratio (IRR) among smokers of 2.10 (95% CI 1.53-2.89) and among nonsmokers of 1.39 (95% CI 1.03-1.86), when compared to headache-free controls. A moderate risk increase was seen for migraine without aura (IRR 1.26, 95% CI 1.12-1.42) and nonmigraine headache (IRR 1.22, 95% CI 1.13-1.32), not modified by smoking. The results suggest that traditional risk factors may be one of the mechanisms through which migraine with aura is linked to an increased risk for cardiovascular disease. A heightened vigilance concerning cardiovascular risk factors in this patient group may be warranted.  
  Address Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. b.k.winsvold@medisin.uio.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0304-3959 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23726372 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1386  
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