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Author Bhatta, L.; Leivseth, L.; Mai, X.-M.; Chen, Y.; Henriksen, A.H.; Langhammer, A.; Brumpton, B.M. url  doi
  Title Prevalence and trend of COPD from 1995-1997 to 2006-2008: The HUNT study, Norway Type Journal Article
  Year 2018 Publication Respiratory Medicine Abbreviated Journal Respir Med  
  Volume 138 Issue Pages 50-56  
  Keywords Adult; Age Distribution; Aged; Disease Progression; Female; Forced Expiratory Volume/physiology; Forecasting; Health Surveys; Humans; Incidence; Male; Middle Aged; Norway/epidemiology; Prevalence; Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology; Severity of Illness Index; Sex Distribution; Spirometry/methods; Vital Capacity/physiology; *Chronic obstructive pulmonary disease; *Incidence; *Norway; *Prevalence; *Symptoms; *Trends  
  Abstract BACKGROUND: COPD is a major cause of morbidity and mortality across the world and new estimates of prevalence and trend are of great importance. We aimed to estimate the prevalence and trend of COPD from 1995-1997 to 2006-2008 in Norwegian adults >/=40 years from the Nord-Trondelag Health Study. MATERIAL AND METHODS: COPD was assessed using a fixed-ratio and lower limit of normal (LLN) criteria. Pre-bronchodilator spirometry was performed during 1995-1997 (n=7158) and 2006-2008 (n=8788). The prevalence of COPD was weighted using the inverse probability of selection and predicted probability of response. RESULTS: The prevalence of pre-bronchodilator COPD was 16.7% in 1995-1997 and 14.8% in 2006-2008 using fixed-ratio criteria, and 10.4% in 1995-1997 and 7.3% in 2006-2008 using LLN criteria. The prevalence of LLN COPD was higher among men (13.0% in 1995-1997, 7.7% in 2006-2008) than women (8.0% in 1995-1997, 6.9% in 2006-2008). From 1995-1997 to 2006-2008, the prevalence decreased among men but remained relatively stable among women. Over the 11-year period, the cumulative incidence of pre-bronchodilator COPD using LLN criteria was 3.3% and 2.7% among men and women respectively. The prevalence of self-reported asthma and respiratory symptoms increased. CONCLUSIONS: The prevalence declined in men but not in women from 1995-1997 to 2006-2008, and was consistently higher among men than women.  
  Address Department of Thoracic Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0954-6111 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29724393 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2072  
Permanent link to this record
 

 
Author Henriksen, A.H.; Langhammer, A.; Steinshamn, S.; Mai, X.-M.; Brumpton, B.M. url  doi
  Title The Prevalence and Symptom Profile of Asthma-COPD Overlap: The HUNT Study Type Journal Article
  Year 2017 Publication Copd Abbreviated Journal Copd  
  Volume Issue Pages 1-9  
  Keywords Acos; epidemiology; obstructive lung disease; spirometry  
  Abstract The concept of asthma and COPD as separate conditions has been questioned, and the term asthma-COPD overlap syndrome has been introduced. We assessed the prevalence, symptoms, and lifestyle factors of asthma-COPD overlap (ACO) in a large Norwegian population-based study. From 2006 to 2008, a total of 50,777 residents of Nord-Trondelag participated in the Nord-Trondelag Health Study, Norway. They completed questionnaires regarding respiratory symptoms, disease status, and medication use. We estimated the prevalence and 95% confidence intervals of ACO. Additionally, spirometry was used to estimate the prevalence of ACO in a subgroup. The prevalence of self-reported ACO was 1.9%, and in age groups <40, 40-60 and >/=60 years it was 0.7%, 1.4%, and 3.2%, respectively. Among those reporting COPD, the proportion of ACO was 0.56. In the spirometry subgroup when ACO was defined as doctor diagnosed asthma ever and FEV1/FVC < 0.70, the prevalence of ACO was 2.0%. All respiratory symptoms, separately or in combination, as well as medication use were reported most frequently in those with ACO compared to the other groups. Strikingly, we observed a two-fold higher proportion of allergic rhinitis in ACO compared to COPD only. In this Norwegian population, the prevalence of self-reported ACO was 1.9%, and the corresponding proportion of ACO among those with COPD was 0.56. Participants with ACO generally had the highest proportions of respiratory symptoms compared to asthma or COPD.  
  Address d K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences , Norwegian University of Science and Technology , Trondheim , Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1541-2563 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29257905 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1927  
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Author Henriksen, A.H.; Langhammer, A.; Steinshamn, S.; Mai, X.-M.; Brumpton, B.M. url  doi
  Title The Prevalence and Symptom Profile of Asthma-COPD Overlap: The HUNT Study Type Journal Article
  Year 2018 Publication Copd Abbreviated Journal Copd  
  Volume 15 Issue 1 Pages 27-35  
  Keywords *Acos; *epidemiology; *obstructive lung disease; *spirometry  
  Abstract The concept of asthma and COPD as separate conditions has been questioned, and the term asthma-COPD overlap syndrome has been introduced. We assessed the prevalence, symptoms, and lifestyle factors of asthma-COPD overlap (ACO) in a large Norwegian population-based study. From 2006 to 2008, a total of 50,777 residents of Nord-Trondelag participated in the Nord-Trondelag Health Study, Norway. They completed questionnaires regarding respiratory symptoms, disease status, and medication use. We estimated the prevalence and 95% confidence intervals of ACO. Additionally, spirometry was used to estimate the prevalence of ACO in a subgroup. The prevalence of self-reported ACO was 1.9%, and in age groups <40, 40-60 and >/=60 years it was 0.7%, 1.4%, and 3.2%, respectively. Among those reporting COPD, the proportion of ACO was 0.56. In the spirometry subgroup when ACO was defined as doctor diagnosed asthma ever and FEV1/FVC < 0.70, the prevalence of ACO was 2.0%. All respiratory symptoms, separately or in combination, as well as medication use were reported most frequently in those with ACO compared to the other groups. Strikingly, we observed a two-fold higher proportion of allergic rhinitis in ACO compared to COPD only. In this Norwegian population, the prevalence of self-reported ACO was 1.9%, and the corresponding proportion of ACO among those with COPD was 0.56. Participants with ACO generally had the highest proportions of respiratory symptoms compared to asthma or COPD.  
  Address d K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences , Norwegian University of Science and Technology , Trondheim , Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1541-2563 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29257905 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2095  
Permanent link to this record
 

 
Author Larose, T.L.; Brumpton, B.M.; Langhammer, A.; Camargo, C.A.J.; Chen, Y.; Romundstad, P.; Mai, X.M.   
  Title Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study Type Journal Article
  Year 2015 Publication Eur Respir J Abbreviated Journal The European respiratory journal  
  Volume 46 Issue 2 Pages 355-363  
  Keywords Adult; Cross-Sectional Studies; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Norway/epidemiology; Odds Ratio; Smoking/*blood/*epidemiology; Spirometry; Vitamin D/*analogs & derivatives/blood; Young Adult  
  Abstract The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear.We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate the interrelationship of serum 25(OH)D, smoking and lung function changes in a random sample of adults from the Nord-Trondelag Health (HUNT) Study, Norway.Lung function was measured using spirometry and included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/FVC ratio. Multiple linear and logistic regression models estimated the adjusted difference in lung function measures or lung function decline, adjusted odds ratios for impaired lung function or development of impaired lung function and 95% confidence intervals.40% of adults had serum 25(OH)D levels  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Scien Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Larose2015b Serial 1837  
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Author Leivseth L, Brumpton BM, Nilsen TI, Mai XM, Johnsen R, Langhammer A. doi 
  Title GOLD classifications and mortality in chronic obstructive pulmonary disease: the HUNT Study, Norway. Type Journal Article
  Year 2013 Publication Thorax Abbreviated Journal  
  Volume 68 Issue 10 Pages  
  Keywords HUNT2; COPD Exacerbations; COPD epidemiology; Aged; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lung/physiopathology*; Male; Middle Aged; Norway; Pulmonary Disease, Chronic Obstructive/classification*; Pulmonary Disease, Chronic Obstructive/mortality*; Pulmonary Disease, Chronic Obstructive/physiopathology; Severity of Illness Index; Spirometry; Survival Analysis  
  Abstract BACKGROUND:

How different Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifications of chronic obstructive pulmonary disease (COPD) predict mortality is unclear.

OBJECTIVE:

To examine the association of spirometric GOLD grades and the new ABCD groups with mortality, and to compare their informativeness in relation to mortality.

METHODS:

We studied 1540 people with post-bronchodilator COPD who participated in the Norwegian Nord-Trøndelag Health Study 1995-1997 and were followed up on all-cause mortality until May 2012. The associations of spirometric GOLD grades and ABCD groups with mortality were estimated by sex specific adjusted HRs from Cox regression and standardised mortality ratios. To assess the informativeness of spirometric GOLD grades and ABCD groups at predicting mortality we used the difference in twice the log-likelihood of a Cox regression model with and without each COPD classification.

RESULTS:

The distribution of participants was 28% in GOLD 1, 57% in GOLD 2, 13% in GOLD 3 and 2% in GOLD 4, in contrast to 61% in group A, 18% in group B, 12% in group C and 10% in group D. During a median of 14.6 years of follow-up, 837 people (54%) died. Mortality increased gradually from GOLD 1 to 4, while it was generally similar in groups A and B, and in groups C and D. Spirometric GOLD grades were substantially more informative than ABCD groups at predicting mortality.

CONCLUSIONS:

Spirometric GOLD grades predicted mortality better than the new ABCD groups among people with COPD from a Norwegian general population.
 
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes PMID: 23611880 Approved no  
  Call Number Serial 1312  
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