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Author (up) Brumpton, B.; Langhammer, A.; Romundstad, P.; Chen, Y.; Mai, X.-M. url  doi
  Title General and abdominal obesity and incident asthma in adults: the HUNT study Type Journal Article
  Year 2013 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 41 Issue 2 Pages 323-329  
  Keywords Adult; Asthma/*complications/*epidemiology; Body Mass Index; Female; Humans; Male; Middle Aged; Models, Statistical; Norway; Obesity/*complications/*epidemiology; Odds Ratio; Prospective Studies; Risk Factors; Smoking; Waist Circumference; Young Adult  
  Abstract Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom been investigated. To determine the association between BMI, waist circumference and incident asthma in adults, we conducted a prospective study (n=23,245) in a population living in Nord-Trondelag, Norway in 1995-2008. Baseline BMI and waist circumference were measured and categorised as general obesity (BMI >/=30.0 kg.m(2)) and abdominal obesity (waist circumference >/=88 cm in females and >/=102 cm in males). Incident asthma was self-reported new-onset cases during an 11-yr follow-up period. Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression. General obesity was a risk factor for asthma in females (OR 1.96, 95% CI 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05). Abdominal obesity seems to increase the risk of incident asthma in females in addition to BMI, indicating that using both measures of BMI and waist circumference in females may be a superior clinical assessment for asthma risk than any measure alone.  
  Address Dept. of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ben.brumpton@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22653771 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1461  
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Author (up) Brumpton, B.M.; Langhammer, A.; Henriksen, A.H.; Camargo, C.A.J.; Chen, Y.; Romundstad, P.R.; Mai, X.-M. url  doi
  Title Physical activity and lung function decline in adults with asthma: The HUNT Study Type Journal Article
  Year 2017 Publication Respirology (Carlton, Vic.) Abbreviated Journal Respirology  
  Volume 22 Issue 2 Pages 278-283  
  Keywords Adult; Asthma/*physiopathology; Cohort Studies; Disease Progression; Exercise/*physiology; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Leisure Activities; Male; Middle Aged; Norway; Physical Exertion; Sedentary Lifestyle; Surveys and Questionnaires; Vital Capacity; *forced expiratory volume in 1 s; *forced vital capacity; *leisure time; *peak expiratory flow; *prospective  
  Abstract BACKGROUND AND OBJECTIVE: People with asthma may seek advice about physical activity. However, the benefits of leisure time physical activity on lung function are unclear. We investigated the association between leisure time physical activity and lung function decline in adults with asthma. METHODS: In a population-based cohort study in Norway, we used multiple linear regressions to estimate the annual mean decline in lung function (and 95% CI) in 1329 people with asthma over a mean follow-up of 11.6 years. The durations of light and hard physical activity per week in the last year were collected by questionnaire. Inactive participants did not report any light or hard activity, while active participants reported light or hard activity. RESULTS: The mean decline in forced expiratory volume in 1 s (FEV1 ) was 37 mL/year among inactive participants and 32 mL/year in active participants (difference: -5 mL/year (95% CI: -13 to 3)). The mean decline in forced vital capacity (FVC) was 33 mL/year among inactive participants and 31 mL/year in active participants (difference: -2 mL/year (95% CI: -11 to 7)). The mean decline in FEV1 /FVC ratio was 0.36%/year among inactive participants and 0.22%/year in active participants (difference: -0.14%/year (95% CI: -0.27 to -0.01)). The mean decline in peak expiratory flow (PEF) was 14 mL/year among the inactive participants and 10 mL/year in active participants (difference: -4 mL/year (95% CI: -9 to 1)). CONCLUSION: We observed slightly less decline in lung function in physically active than inactive participants with asthma, particularly for FEV1 , FEV1 /FVC ratio and PEF.  
  Address Faculty of Medicine, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1323-7799 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27696634 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1892  
Permanent link to this record
 

 
Author (up) Brumpton, B.M.; Langhammer, A.; Henriksen, A.H.; Romundstad, P.R.; Chen, Y.; Camargo, C.A.J.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study Type Journal Article
  Year 2018 Publication Respiratory Medicine Abbreviated Journal Respir Med  
  Volume 136 Issue Pages 65-70  
  Keywords Adult; Aged; Asthma/*prevention & control; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Vitamin D/administration & dosage/*analogs & derivatives/blood; Vitamin D Deficiency/*complications/drug therapy; Vitamins/*administration & dosage; Young Adult; *Asthma; *Epidemiology; *Vitamin-D  
  Abstract Few studies have investigated the association between serum 25-hydroxyvitamin D (25[OH]D), vitamin D supplement and asthma control among adults. We aimed to examine whether low levels of serum 25(OH)D or not taking vitamin D supplement were associated with an increased risk of poorly controlled asthma among Norwegian adults with asthma. We used a definition of asthma control adapted from the Global Initiative for Asthma. We first examined cross-sectional associations between serum 25(OH)D (n=806) or vitamin D supplement (n=1179) and poorly controlled asthma. Next, among those with well controlled asthma at baseline, we examined prospective associations between serum 25(OH)D (n=147) or vitamin D supplement (n=208) and poorly controlled asthma at follow-up, approximately 11 years later. We estimated risk ratios (RR) and 95% confidence intervals (CI) with Poisson regression. The adjusted RR for poorly controlled asthma was 1.00 (95% CI, 0.89-1.13) for adults with serum 25(OH)D<50nmol/L in cross-sectional and 1.50 (95% CI, 0.46-4.95) in prospective analyses. The adjusted RR for poorly controlled asthma was 1.17 (95% CI 1.00-1.37) for non-users of vitamin D supplement in cross-sectional and 1.66 (95% CI 0.49-5.67) in prospective analyses. Our study did not show strong evidence that among adults with asthma, having a low serum 25(OH)D or being a non-user of vitamin D supplement was associated with an increased risk of poorly controlled asthma. Some point estimates indicated an increased risk, however our estimates were generally imprecise and further evidence is needed.  
  Address Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0954-6111 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29501248 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2075  
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Author (up) Egan, K.B.; Ettinger, A.S.; DeWan, A.T.; Holford, T.R.; Holmen, T.L.; Bracken, M.B. url  doi
  Title Longitudinal associations between asthma and general and abdominal weight status among Norwegian adolescents and young adults: the HUNT Study Type Journal Article
  Year 2015 Publication Pediatr Obes Abbreviated Journal Pediatric obesity  
  Volume 10 Issue 5 Pages 345-352  
  Keywords Adiposity; Adolescent; Adult; Asthma/epidemiology/etiology/*physiopathology; Body Mass Index; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Norway/epidemiology; Obesity, Abdominal/complications/epidemiology/*physiopathology; Odds Ratio; Overweight; Waist Circumference; Young Adult  
  Abstract BACKGROUND: In adolescents the temporal directionality to the asthma and adiposity association remains unclear. Asthma may be a consequence of obesity; however, asthma may increase adiposity. OBJECTIVES: This study aimed to assess the associations between (i) baseline weight status and subsequent asthma and (ii) baseline asthma and subsequent weight status after 4 and 11 years of follow-up (N = 1543 and N = 1596, respectively) using data from three, sequentially enrolled population-based surveys of Norwegians aged 12-30 years from 1995 to 2008. METHODS: Weight status was defined as general (body mass index) or abdominal (waist circumference) underweight, normal weight, overweight or obesity. Self-report physician-diagnosed asthma defined asthma status. RESULTS: Over the longitudinal 11-year follow-up, baseline generally overweight or abdominally obese adolescents had increased risk of asthma. Likewise, baseline asthmatics had increased risk of general overweight or abdominal obesity. After sex stratification, these associations were stronger in males. Generally (odds ratio [OR] 1.90; 95% confidence interval [CI] 1.32, 2.73) or abdominally (OR 1.66; 95% CI 1.13, 2.44) overweight males were at increased risk of asthma. Baseline asthmatic males were also at increased risk of general (OR 2.14; 95% CI 1.54, 2.98) and abdominal (OR 1.77; 95% CI 1.27, 2.47) overweight. CONCLUSIONS: Among Norwegian adolescents, a bidirectional association of asthma and adiposity was observed in males. Each baseline condition increased the risk of the other condition over time. No association was observed in females.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.Center Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Egan, K BEttinger, A SDeWan, A THolford, T RHolmen, T LBracken, M BengResearch Support, Non-U.S. Gov'tEngland2014/11/19 06:00Pediatr Obes. 2015 Oct;10(5):345-52. doi: 10.1111/ijpo.271. Epub 2014 Nov 18. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Egan2015 Serial 1803  
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Author (up) Egan, K.B.; Ettinger, A.S.; DeWan, A.T.; Holford, T.R.; Holmen, T.L.; Bracken, M.B. url  doi
  Title General, but not abdominal, overweight increases odds of asthma among Norwegian adolescents: the Young-HUNT study Type Journal Article
  Year 2014 Publication Acta Paediatrica (Oslo, Norway : 1992) Abbreviated Journal Acta Paediatr  
  Volume Issue Pages  
  Keywords Young-HUNT; HUNT2; Adolescents; Asthma; Body mass index; Obesity; Overweight; Waist circumference  
  Abstract AIM: The aim of this analysis was to examine the association between asthma and general and abdominal weight status, defined by age- and sex-specific cut-offs for body mass index (BMI) and waist circumference (WC) in adolescents. METHODS: Participants aged 12-19 years in the Young-HUNT (YH) Study (YH1 1995-1997: n = 8222; YH3 2006-2008: n = 7403) completed self-administered questionnaires in school as part of a series of cross-sectional, population-based studies conducted in Nord-Trondelag, Norway. Weight, height and WC were measured. Adjusted odds ratios (ORs) and 95% Confidence Intervals (CI) for asthma, defined by self-reported physician diagnosis, were calculated. Potential effect modifiers evaluated included sex and pubertal development status (PDS). RESULTS: Asthma was reported by 11.8% of the adolescents in YH1 and 17.0% in YH3. Asthma odds significantly increased for adolescents with general (OR = 1.33; 95%CI: 1.13, 1.56), but not abdominal, overweight and increased for adolescents with general (OR = 1.34; 95%CI: 1.02, 1.75) or abdominal obesity (OR = 1.36; 95%CI: 1.16, 1.60). Underweight had no association with asthma regardless of weight assessment type, and PDS did not meaningfully influence the associations between asthma and weight. CONCLUSION: Overweight and obesity both increased the odds of asthma in 12-19 year-old Norwegians. WC did not add further information to that already provided by BMI to improve our understanding of the association between asthma and weight.  
  Address Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA; Yale Graduate School of Arts and Sciences, New Haven, CT, USA; Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University, New Haven, CT, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0803-5253 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25131148 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1639  
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Author (up) Ferreira, M.A.; Vonk, J.M.; Baurecht, H.; Marenholz, I.; Tian, C.; Hoffman, J.D.; Helmer, Q.; Tillander, A.; Ullemar, V.; van Dongen, J.; Lu, Y.; Ruschendorf, F.; Esparza-Gordillo, J.; Medway, C.W.; Mountjoy, E.; Burrows, K.; Hummel, O.; Grosche, S.; Brumpton, B.M.; Witte, J.S.; Hottenga, J.-J.; Willemsen, G.; Zheng, J.; Rodriguez, E.; Hotze, M.; Franke, A.; Revez, J.A.; Beesley, J.; Matheson, M.C.; Dharmage, S.C.; Bain, L.M.; Fritsche, L.G.; Gabrielsen, M.E.; Balliu, B.; Nielsen, J.B.; Zhou, W.; Hveem, K.; Langhammer, A.; Holmen, O.L.; Loset, M.; Abecasis, G.R.; Willer, C.J.; Arnold, A.; Homuth, G.; Schmidt, C.O.; Thompson, P.J.; Martin, N.G.; Duffy, D.L.; Novak, N.; Schulz, H.; Karrasch, S.; Gieger, C.; Strauch, K.; Melles, R.B.; Hinds, D.A.; Hubner, N.; Weidinger, S.; Magnusson, P.K.E.; Jansen, R.; Jorgenson, E.; Lee, Y.-A.; Boomsma, D.I.; Almqvist, C.; Karlsson, R.; Koppelman, G.H.; Paternoster, L. url  doi
  Title Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology Type Meta-Analysis
  Year 2017 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 49 Issue 12 Pages 1752-1757  
  Keywords Asthma/*genetics; Eczema/*genetics; Genetic Predisposition to Disease/*genetics; Genome-Wide Association Study/methods; Humans; Hypersensitivity/*genetics; Phenotype; Polymorphism, Single Nucleotide; Rhinitis, Allergic, Seasonal/*genetics; Risk Factors  
  Abstract Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS; n = 360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P < 3 x 10(-8)), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology. Disease-specific effects were detected for only six variants, confirming that most represent shared risk factors. Tissue-specific heritability and biological process enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity. Six target genes provide an opportunity for drug repositioning, while for 36 genes CpG methylation was found to influence transcription independently of genetic effects. Asthma, hay fever and eczema partly coexist because they share many genetic risk variants that dysregulate the expression of immune-related genes.  
  Address MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK  
  Corporate Author LifeLines Cohort Study Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29083406 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1903  
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Author (up) Larose, T.L.   
  Title Vitamin D status in a Norwegian population: any link to lung function? Type Book Whole
  Year 2015 Publication Abbreviated Journal  
  Volume PhD Issue Pages  
  Keywords HUNT2; HUNT3; asthma  
  Abstract Vitamin D is predominantly synthesized from precursors in the skin after direct exposure to ultraviolet B radiation from the sun. Vitamin D can also be obtained by dietary intake of vitamin D rich food, or by supplement intake. Poor vitamin D status has been reported worldwide. Determinants include unexposed skin, high latitude, winter season, and high body mass index (BMI). Serum 25-hydroxyvitamin D (25(OH)D) is the major circulating metabolite of vitamin D and considered the best marker of vitamin D status. The association between vitamin D status and bone health is well studied, and increasing evidence suggests an association between low serum 25(OH)D level and range of non-skeletal health outcomes including respiratory disorders, such as asthma.This dissertation uses data from the Nord-Trøndelag Health Study (HUNT), one of the largest population based health studies in Norway, with clinical, lifestyle and environmental information on more than 130,000 people collected over 25 years. Using data from HUNT2 (1995-1997) and HUNT3 (2006-2008), we investigated: 1) the prevalence of vitamin D deficiency (serum 25(OH)D  
  Address  
  Corporate Author Thesis Ph.D. thesis  
  Publisher NTNU Place of Publication Trondheim Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Larose2015a Serial 1836  
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Author (up) Larose, T.L.; Langhammer, A.; Chen, Y.; Camargo, C.A.J.; Romundstad, P.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study Type Journal Article
  Year 2015 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 45 Issue 4 Pages 1019-1026  
  Keywords asthma; HUNT3  
  Abstract The association between vitamin D status and lung function in adults with asthma remains unclear. We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19-55 years) with self-reported asthma in the Nord-Trondelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol.L(-1) was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (beta) and 95% confidence intervals. 44% of asthma adults had serum 25(OH)D levels <50 nmol.L(-1). Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol.L(-1) was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol.L(-1) was significantly associated with lower FEV1/FVC ratio (beta=-8.60%; 95% CI: -16.95%- -0.25%). Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25395037 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1686  
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Author (up) Larose, Tricia   
  Title Vitamin D status in a Norwegian population: any link to lung function? Type Book Whole
  Year 2015 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords HUNT2; HUNT3; asthma; lungs; vitamin D  
  Abstract Vitamin D is predominantly synthesized from precursors in the skin after direct exposure to ultraviolet B radiation from the sun. Vitamin D can also be obtained by dietary intake of vitamin D rich food, or by supplement intake. Poor vitamin D status has been reported worldwide. Determinants include unexposed skin, high latitude, winter season, and high body mass index (BMI). Serum 25-hydroxyvitamin D (25(OH)D) is the major circulating metabolite of vitamin D and considered the best marker of vitamin D status. The association between vitamin D status and bone health is well studied, and increasing evidence suggests an association between low serum 25(OH)D level and range of non-skeletal health outcomes including respiratory disorders, such as asthma.

This dissertation uses data from the Nord-Trøndelag Health Study (HUNT), one of the largest population based health studies in Norway, with clinical, lifestyle and environmental information on more than 130,000 people collected over 25 years. Using data from HUNT2 (1995-1997) and HUNT3 (2006-2008), we investigated: 1) the prevalence of vitamin D deficiency (serum 25(OH)D<50nmol/L) in a general adult population and factors associated with vitamin D deficiency; 2) the association between serum 25(OH)D level and lung function (LF) in adults with asthma; and 3) the interrelationship between serum 25(OH)D level, smoking and LF changes in a general adult population.

We found a high prevalence of vitamin D deficiency in this Norwegian population (40% overall), particularly in winter months (64%). Besides season and high BMI, several potentially modifiable lifestyle factors were associated with vitamin D deficiency. We also found that low serum 25(OH)D level was not associated with airway obstruction in most adults with asthma, with the exception of men with asthma but without allergy status. Finally, we found no clear associations between serum 25(OH)D levels and LF changes in never smokers, whereas we did observe significant associations in ever smokers.

Replication and confirmation of these findings via well-designed prospective and intervention studies is required to determine if vitamin D supplementation is a potentially cost effective, safe and straightforward means of asthma control or disease mitigation in ever smokers.
 
  Address  
  Corporate Author Thesis Doctoral thesis  
  Publisher NTNU Place of Publication Trondheim Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1685  
Permanent link to this record
 

 
Author (up) Lonnee-Hoffmann, R.A.; Salvesen, O.; Morkved, S.; Schei, B.   
  Title Self-reported pelvic organ prolapse surgery, prevalence, and nonobstetric risk factors: findings from the Nord Trondelag Health Study Type Journal Article
  Year 2015 Publication Int Urogynecol J Abbreviated Journal International urogynecology journal  
  Volume 26 Issue 3 Pages 407-414  
  Keywords Adult; Age Factors; Aged; Aged, 80 and over; Asthma/epidemiology; Body Mass Index; Constipation/epidemiology; Cross-Sectional Studies; Female; Health Surveys; Humans; Incidence; Lifting; Middle Aged; Norway/epidemiology; Occupations; Pelvic Organ Prolapse/*epidemiology/*surgery; Prevalence; Pulmonary Disease, Chronic Obstructive/epidemiology; Risk Factors; Self Report; Smoking/epidemiology  
  Abstract INTRODUCTION: The aim of this study was to assess prevalence and risk factors of self-reported pelvic organ prolapse (POP) surgery in a Nordic county. METHODS: We assessed cross-sectional data collection from participants in the Nord-Trondelag Health Study in 2006-2008. All women in the county >/=30 years were eligible, of whom 20,285 (50.3 %) responded by completing questionnaires and attending screening stations. Outcome measures were self-reported POP surgery, age at survey, sociodemographic factors, and information on selected risk factors for POP: self-reported smoking, chronic obstructive pulmonary disease (COPD), asthma, constipation a decade prior, and measured body mass index (BMI). Descriptive statistics, Kaplan-Meier estimates, and multivariate logistic regression were used. Statistical significance was defined as p  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Public Health and General Practice, Norwegian University of Science and Technology, Po Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Lonnee-Hoffmann2015a Serial 1842  
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Author (up) Mai, X.-M.; Langhammer, A.; Camargo, C.A.J.; Chen, Y. url  doi
  Title Serum 25-hydroxyvitamin D levels and incident asthma in adults: the HUNT Study Type Journal Article
  Year 2012 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 176 Issue 12 Pages 1169-1176  
  Keywords Adult; Asthma/*epidemiology; Case-Control Studies; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Norway/epidemiology; Prospective Studies; Rhinitis, Allergic, Perennial/epidemiology; Risk Factors; Sex Distribution; Vitamin D/*analogs & derivatives/blood; Vitamin D Deficiency/*epidemiology  
  Abstract The impact of low vitamin D status on asthma development is unclear. The authors investigated the relation between the baseline serum 25-hydroxyvitamin D (25(OH)D) level and incident asthma in adults, including possible effect modification by allergy status, using allergic rhinitis as a proxy measure. A cohort of 25,616 Norwegian adults aged 19-55 years participated in 2 surveys of the Nord-Trondelag Health Study known as HUNT 2 (1995-1997) and HUNT 3 (2006-2008). Of this cohort, a nested case-control study included 584 new-onset asthma cases and 1,958 nonasthma controls whose baseline serum 25(OH)D levels were measured. After adjustment for potential asthma risk factors, the baseline serum level of 25(OH)D (<50 nmol/L) was not significantly associated with asthma in either women (adjusted odds ratio = 0.94, 95% confidence interval (CI): 0.67, 1.32) or men (adjusted odds ratio = 1.47, 95% CI: 0.93, 2.32). In men, allergic rhinitis modified the association with the adjusted odds ratio being 0.87 (95% CI: 0.36, 2.06) among men with allergic rhinitis and 2.32 (95% CI: 1.06, 5.10) among men without allergic rhinitis. The serum 25(OH)D level was not associated with incident asthma in women, regardless of allergy status. Low vitamin D status was not significantly associated with incident asthma in most adults, but it may have increased risk among men without allergy.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. xiao-mei.mai@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23204497 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1552  
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Author (up) Mai, X.-M.; Langhammer, A.; Chen, Y.; Camargo, C.A.J. url  doi
  Title Cod liver oil intake and incidence of asthma in Norwegian adults--the HUNT study Type Journal Article
  Year 2013 Publication Thorax Abbreviated Journal Thorax  
  Volume 68 Issue 1 Pages 25-30  
  Keywords Adult; Age Distribution; Asthma/*epidemiology/*etiology/physiopathology; Cod Liver Oil/administration & dosage/*adverse effects; Cross-Sectional Studies; Dietary Supplements/*adverse effects; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Incidence; Logistic Models; Male; Multivariate Analysis; Norway/epidemiology; Odds Ratio; Questionnaires; Reference Values; Risk Assessment; Sex Distribution; Vitamin A/administration & dosage/*adverse effects; Young Adult  
  Abstract BACKGROUND: Cod liver oil is an important source of vitamin D, but also contains other fat-soluble components such as vitamin A. Before 1999, the cod liver oil formula in Norway contained a high concentration of vitamin A (1000 microg per 5 ml). High vitamin A status is associated with increased risks of several chronic diseases. OBJECTIVE: To investigate the association between cod liver oil intake and asthma development. METHODS: In the Nord-Trondelag Health Study, a total of 25 616 Norwegian adults aged 19-55 years were followed up from 1995-1997 to 2006-2008. Current analysis based on 17 528 subjects who were free of asthma and had complete information on cod liver oil intake at baseline. Cod liver oil intake was defined as daily intake >/= 1 month during the year prior to baseline. Incident asthma was reported as new-onset asthma during the 11-year follow-up. RESULTS: Of the 17 528 subjects, 18% (n=3076) consumed cod liver oil daily for >/= 1 month over the past year. Cod liver oil intake was significantly associated with incident asthma with an OR of 1.62 (95% CI 1.32 to 1.98) after adjustment for age, sex, daily smoking, physical activity, education, socio-economic status, family history of asthma, and body mass index (BMI). The positive association was consistent across age (< 40/>/= 40 years), sex (men/women), family history of asthma (yes/no) and BMI subgroups (< 25/>/= 25 kg/m(2)). CONCLUSIONS: Intake of cod liver oil with high vitamin A content was significantly associated with increased incidence of adult-onset asthma.  
  Address Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway. xiao-mei.mai@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0040-6376 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22977130 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1424  
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Author (up) Quanjer, P.H.; Ruppel, G.L.; Langhammer, A.; Krishna, A.; Mertens, F.; Johannessen, A.; Menezes, A.M.B.; Wehrmeister, F.C.; Perez-Padilla, R.; Swanney, M.P.; Tan, W.C.; Bourbeau, J. url  doi
  Title Bronchodilator Response in FVC Is Larger and More Relevant Than in FEV1 in Severe Airflow Obstruction Type Journal Article
  Year 2017 Publication Chest Abbreviated Journal Chest  
  Volume 151 Issue 5 Pages 1088-1098  
  Keywords Adolescent; Adult; Aged; Aged, 80 and over; Airway Obstruction/*diagnosis/physiopathology; Asthma/*diagnosis/physiopathology; *Bronchodilator Agents; Canada; Child; Child, Preschool; Female; Forced Expiratory Volume/*physiology; Healthy Volunteers; Humans; Latin America; Male; Middle Aged; Netherlands; New Zealand; Norway; Pulmonary Disease, Chronic Obstructive/*diagnosis/physiopathology; Severity of Illness Index; Treatment Outcome; United States; Vital Capacity/*physiology; Young Adult; airways obstruction; asthma; bronchodilator responsiveness; chronic obstructive pulmonary disease; respiratory physiology  
  Abstract BACKGROUND: Recommendations on interpreting tests of bronchodilator responsiveness (BDR) are conflicting. We investigated the dependence of BDR criteria on sex, age, height, ethnicity, and severity of respiratory impairment. METHODS: BDR test data were available from clinical patients in the Netherlands, New Zealand, and the United States (n = 15,278; female subjects, 51.7%) and from surveys in Canada, Norway, and five Latin-American countries (n = 16,250; female subjects, 54.7%). BDR calculated according to FEV1, FVC, and FEV1/FVC was expressed as absolute change, a percentage of the baseline level (% baseline), a percentage of the predicted value (% predicted), and z score. RESULTS: Change (Delta) in FEV1 and FVC, in milliliters, was unrelated to the baseline value but was biased toward age, height, sex, and level of airways obstruction; DeltaFEV1 was significantly lower in African Americans. In 1,106 subjects with low FEV1 (200-1,621 mL) the FEV1 increased by 12% to 44.7% relative to baseline but < 200 mL. Expressing BDR as a percentage of the predicted value or as a z score attenuated the bias and made the 200-mL criterion redundant, but reduced positive responses by half. DeltaFEV1 % baseline increased with the level of airflow obstruction but decreased with severe obstruction when expressed as z scores or % predicted; DeltaFVC, however expressed, increased with the level of airflow obstruction. CONCLUSIONS: Expressing FEV1 responsiveness as % baseline spuriously suggests that responsiveness increases with the severity of respiratory impairment. Expressing change in FEV1 or FVC as % predicted or as z scores eliminates this artifact and renders the required 200-mL minimum increase redundant. In severe airways obstruction DeltaFVC should be critically evaluated as an index of clinically important relief of hyperinflation, with implications for bronchodilator drug trials.  
  Address Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, QC, Canada  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28040521 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1971  
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