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Author Gemes, K.; Janszky, I.; Strand, L.B.; Laszlo, K.D.; Ahnve, S.; Vatten, L.J.; Dalen, H.; Mukamal, K.J. url  doi
  Title Light-moderate alcohol consumption and left ventricular function among healthy, middle-aged adults: the HUNT study Type Journal Article
  Year 2018 Publication BMJ Open Abbreviated Journal BMJ Open  
  Volume 8 Issue 5 Pages e020777  
  Keywords *cardiac epidemiology; *echocardiography; *epidemiology; *moderate alcohol consumption  
  Abstract OBJECTIVES: To investigate the association between alcohol consumption and left ventricular (LV) function in a population with low average alcohol intake. DESIGN, SETTING AND PARTICIPANTS: A total of 1296 healthy participants, free from cardiovascular diseases, were randomly selected from the third wave of the Norwegian HUNT study (2006-2008) and underwent echocardiography. After validation of the inclusion criteria, 30 participants were excluded due to arrhythmias or myocardial or valvular pathology. Alcohol consumption, sociodemographic and major cardiovascular risk factors were assessed by questionnaires and clinical examination in the HUNT3. General linear models were used to analyse the cross-sectional associations between alcohol intake and LV indices. PRIMARY AND SECONDARY OUTCOME MEASURES: LV functional and structural indices were measured with tissue Doppler and speckle tracking echocardiography. RESULTS: We observed no associations between alcohol consumption and multivariable-adjusted LV functional indices. Excluding abstainers who reported regular alcohol consumption 10 years prior to the baseline did not change the results. Alcohol consumption was positively associated with LV mass indices (p<0.01 for linear trend of the means); there was no such association among participants with non-risky drinking characteristics (p=0.67 for linear trend of the means). CONCLUSIONS: We found no clear evidence that light-moderate alcohol consumption is associated with measures of LV function, although our results indicate that consumption, especially when marked by binge drinking, is progressively associated with greater LV mass.  
  Address Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2044-6055 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29724742; PMCID:PMC5988097 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2084  
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Author Selmeryd, J.; Henriksen, E.; Dalen, H.; Hedberg, P. url  doi
  Title Derivation and Evaluation of Age-Specific Multivariate Reference Regions to Aid in Identification of Abnormal Filling Patterns: The HUNT and VaMIS Studies Type Journal Article
  Year 2017 Publication JACC. Cardiovascular Imaging Abbreviated Journal JACC Cardiovasc Imaging  
  Volume Issue Pages  
  Keywords Doppler; diastolic dysfunction; echocardiography; heart failure; reference values  
  Abstract OBJECTIVES: This study aimed to derive age-specific multivariate reference regions (MVRs) able to classify subjects into those having normal or abnormal filling patterns and to evaluate the prognostic impact of this classification. BACKGROUND: The integration of several parameters is necessary to diagnose disorders of left ventricular (LV) filling because no single measurement accurately describes the complexity of diastolic function. However, no generally accepted validated multiparametric algorithm currently exists. METHODS: A cohort of 1,240 apparently healthy subjects from HUNT (the Nord-Trondelag Health Study) with measured early (E) and late (A) mitral inflow velocity and early mitral annular diastolic tissue velocity (e') were used to derive univariate 95% reference bands and age-specific MVRs. Subsequently, the prognostic impact of this MVR-based classification was evaluated by Cox regression in a community-based cohort (n = 726) and in a cohort of subjects with recent acute myocardial infarction (n = 551). Both evaluation cohorts were derived from VaMIS (the Vastmanland Myocardial Infarction Study). RESULTS: Univariate reference bands and MVRs are presented graphically and as regression equations. After adjustment for sex, age, hypertension, body mass index, diabetes, prior ischemic heart disease, LV mass, LV ejection fraction, and left atrial size, the hazard ratio associated with abnormal filling patterns in the community-based cohort was 3.5 (95% confidence interval: 1.7 to 7.0; p < 0.001) and that in the acute myocardial infarction cohort was 1.8 (95% confidence interval: 1.1 to 2.8; p = 0.011). CONCLUSIONS: This study derived age-specific MVRs for identification of abnormal LV filling patterns and showed, in a community-based cohort and in a cohort of patients with recent acute myocardial infarction, that these MVRs conveyed important prognostic information. An MVR-based classification of LV filling patterns could lead to more consistent diagnostic algorithms for identification of different filling disorders.  
  Address Department of Clinical Physiology, Vastmanland County Hospital, Vasteras, Sweden; Centre for Clinical Research, Uppsala University, Vastmanland County Hospital, Vasteras, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1876-7591 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28734926 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1977  
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Author Selmeryd, J.; Henriksen, E.; Dalen, H.; Hedberg, P. url  doi
  Title Derivation and Evaluation of Age-Specific Multivariate Reference Regions to Aid in Identification of Abnormal Filling Patterns: The HUNT and VaMIS Studies Type Journal Article
  Year 2018 Publication JACC. Cardiovascular Imaging Abbreviated Journal JACC Cardiovasc Imaging  
  Volume 11 Issue 3 Pages 400-408  
  Keywords Doppler; diastolic dysfunction; echocardiography; heart failure; reference values  
  Abstract OBJECTIVES: This study aimed to derive age-specific multivariate reference regions (MVRs) able to classify subjects into those having normal or abnormal filling patterns and to evaluate the prognostic impact of this classification. BACKGROUND: The integration of several parameters is necessary to diagnose disorders of left ventricular (LV) filling because no single measurement accurately describes the complexity of diastolic function. However, no generally accepted validated multiparametric algorithm currently exists. METHODS: A cohort of 1,240 apparently healthy subjects from HUNT (Nord-Trondelag Health Study) with measured early (E) and late (A) mitral inflow velocity and early mitral annular diastolic tissue velocity (e') were used to derive univariate 95% reference bands and age-specific MVRs. Subsequently, the prognostic impact of this MVR-based classification was evaluated by Cox regression in a community-based cohort (n = 726) and in a cohort of subjects with recent acute myocardial infarction (n = 551). Both evaluation cohorts were derived from VaMIS (the Vastmanland Myocardial Infarction Study). RESULTS: Univariate reference bands and MVRs are presented graphically and as regression equations. After adjustment for sex, age, hypertension, body mass index, diabetes, prior ischemic heart disease, LV mass, LV ejection fraction, and left atrial size, the hazard ratio associated with abnormal filling patterns in the community-based cohort was 3.5 (95% confidence interval: 1.7 to 7.0; p < 0.001) and that in the acute myocardial infarction cohort was 1.8 (95% confidence interval: 1.1 to 2.8; p = 0.011). CONCLUSIONS: This study derived age-specific MVRs for identification of abnormal LV filling patterns and showed, in a community-based cohort and in a cohort of patients with recent acute myocardial infarction, that these MVRs conveyed important prognostic information. An MVR-based classification of LV filling patterns could lead to more consistent diagnostic algorithms for identification of different filling disorders.  
  Address Department of Clinical Physiology, Vastmanland County Hospital, Vasteras, Sweden; Centre for Clinical Research, Uppsala University, Vastmanland County Hospital, Vasteras, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1876-7591 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28734926 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2149  
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Author Stoylen, A.; Molmen, H.E.; Dalen, H. url  doi
  Title Relation between Mitral Annular Plane Systolic Excursion and Global longitudinal strain in normal subjects: The HUNT study Type Journal Article
  Year 2018 Publication Echocardiography (Mount Kisco, N.Y.) Abbreviated Journal Echocardiography  
  Volume 35 Issue 5 Pages 603-610  
  Keywords Echocardiography/*methods; Female; Heart Ventricles/*diagnostic imaging/physiopathology; Humans; Male; Middle Aged; Mitral Valve/*diagnostic imaging; Prospective Studies; Reference Values; Stroke Volume; Systole; Ventricular Dysfunction, Left/diagnosis/*physiopathology; Ventricular Function, Left/*physiology; *global longitudinal strain; *left ventricular shortening; *mitral annular plane systolic excursion; *normalization  
  Abstract BACKGROUND: Left ventricular (LV) systolic long-axis shortening can be measured as Mitral Annular Plane Systolic Excursion (MAPSE). Global longitudinal strain (GLS) is relative LV shortening, equivalent to normalizing MAPSE for LV length (MAPSEn). The objective of this study was to test whether normalizing LV shortening reduced biological variability of MAPSE due to normalizing for heart size and, possibly BSA. Secondly to provide normal reference values for MAPSE. METHODS AND RESULTS: A total of 1266 subjects from the Nord-Trondelag Health Study (HUNT), without evidence of heart disease were examined. MAPSE and wall lengths were measured in all three standard apical views, while GLS has been published previously. Mean MAPSE was 1.58 (0.25) cm, MAPSEn 16.3 (2.4)%, and GLS 16.7 (2.4)%. All measures declined with age, correlations between -0.50 and -0.41. MAPSE was gender independent, and less BSA dependent than MAPSEn and GLS, while relative standard deviations (SDs) were similar for all three measures. CONCLUSIONS: MAPSE, MAPSEn, and GLS have similar biological variability, which is mainly due to age variation, indicating they are equivalent in normal, and normalizing for BSA will not reduce the variability. Normalizing MAPSE for LV length (MAPSEn and GLS) normalizes for one dimension only, inducing a systematic error, which increases BSA and gender dependence. Normal age-related, gender-independent values for MAPSE are provided.  
  Address Department of Medicine, Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-2822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29399886 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2176  
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