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Author Chau, J.Y.; Grunseit, A.; Midthjell, K.; Holmen, J.; Holmen, T.L.; Bauman, A.E.; van der Ploeg, H.P. url  doi
  Title Cross-sectional associations of total sitting and leisure screen time with cardiometabolic risk in adults. Results from the HUNT Study, Norway Type Journal Article
  Year 2014 Publication Journal of Science and Medicine in Sport / Sports Medicine Australia Abbreviated Journal J Sci Med Sport  
  Volume 17 Issue 1 Pages 78-84  
  Keywords BMI; CMD; Cardiovascular diseases; Epidemiology; GGT; HDL; HUNT; Nord-Trøndelag Health Study, Norway (HelseUndersøkelsen i Nord-Trøndelag); Physical activity; Sedentary lifestyle; WC; body mass index; cardiometabolic disease; gamma glutamyltransferase; high density lipoprotein; waist circumference  
  Abstract OBJECTIVES: To examine associations of total sitting time, TV-viewing and leisure-time computer use with cardiometabolic risk biomarkers in adults. DESIGN: Population based cross-sectional study. METHODS: Waist circumference, BMI, total cholesterol, HDL cholesterol, blood pressure, non-fasting glucose, gamma glutamyltransferase (GGT) and triglycerides were measured in 48,882 adults aged 20 years or older from the Nord-Trondelag Health Study 2006-2008 (HUNT3). Adjusted multiple regression models were used to test for associations between these biomarkers and self-reported total sitting time, TV-viewing and leisure-time computer use in the whole sample and by cardiometabolic disease status sub-groups. RESULTS: In the whole sample, reporting total sitting time >/=10 h/day was associated with poorer BMI, waist circumference, total cholesterol, HDL cholesterol, diastolic blood pressure, systolic blood pressure, non-fasting glucose, GGT and triglyceride levels compared to those reporting total sitting time <4h/day (all p<0.05). TV-viewing >/=4 h/day was associated with poorer BMI, waist circumference, total cholesterol, HDL cholesterol, systolic blood pressure, GGT and triglycerides compared to TV-viewing <1h/day (all p<0.05). Leisure-time computer use >/=1 h/day was associated with poorer BMI, total cholesterol, diastolic blood pressure, GGT and triglycerides compared with those reporting no leisure-time computing. Sub-group analyses by cardiometabolic disease status showed similar patterns in participants free of cardiometabolic disease, while similar albeit non-significant patterns were observed in those with cardiometabolic disease. CONCLUSIONS: Total sitting time, TV-viewing and leisure-time computer use are associated with poorer cardiometabolic risk profiles in adults. Reducing sedentary behaviour throughout the day and limiting TV-viewing and leisure-time computer use may have health benefits.  
  Address Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Australia; Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1878-1861 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23619159 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1496  
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Author Markovitz, A.R.; Haug, E.B.; Horn, J.; Fraser, A.; Macdonald-Wallis, C.; Tilling, K.; Rimm, E.B.; Missmer, S.A.; Williams, P.L.; Romundstad, P.R.; Asvold, B.O.; Rich-Edwards, J.W. url  doi
  Title Does pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway Type Journal Article
  Year 2018 Publication Journal of Lipid Research Abbreviated Journal J Lipid Res  
  Volume 59 Issue 12 Pages 2403-2412  
  Keywords Nord-Trondelag Health Study; cholesterol; epidemiology; high density lipoprotein; mixed model; parity; spline; triglycerides  
  Abstract We examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trondelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline models, we estimated differences in nonfasting lipid levels from before to after first birth in parous women and between parous and nulliparous women. HDL cholesterol (HDL-C) dropped by -4.2 mg/dl (95% CI: -5.0, -3.3) from before to after first birth in adjusted models, a 7% change, and the total cholesterol (TC) to HDL-C ratio increased by 0.18 (95% CI: 0.11, 0.25), with no change in non-HDL-C or triglycerides. Changes in HDL-C and the TC/HDL-C ratio associated with pregnancy persisted for decades, leading to altered life-course lipid trajectories. For example, parous women had a lower HDL-C than nulliparous women at the age of 50 years (-1.4 mg/dl; 95% CI: -2.3, -0.4). Adverse changes in lipids were greatest after first birth, with small changes after subsequent births, and were larger in women who did not breastfeed. Findings suggest that pregnancy is associated with long-lasting adverse changes in HDL-C, potentially setting parous women on a more atherogenic trajectory than prior to pregnancy.  
  Address Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-2275 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30314998; PMCID:PMC6277164 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2132  
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