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Author Jacobsen, L.M.; Winsvold, B.S.; Romundstad, S.; Pripp, A.H.; Holmen, J.; Zwart, J.-A. url  doi
  Title Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway Type Journal Article
  Year 2013 Publication BMJ Open Abbreviated Journal BMJ Open  
  Volume 3 Issue 8 Pages  
  Keywords (up) Vascular Medicine  
  Abstract OBJECTIVE: To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients. DESIGN: A population-based health study. PARTICIPANTS: 303 patients with migraine, 1009 patients with non-migraine headache and 5287 headache-free controls. OUTCOMES: The association between urine albumin- to-creatine ratio (ACR) and headache status was investigated in the Nord-Trondelag Health Study (HUNT-2). Patients were selected in two strata, based on either (1) self-reported hypertension/diabetes (morbid sample) or (2) a random sample. Analyses were performed using analysis of covariance. RESULTS: There was no association between headache status and ACR in the study population (p=0.23, mean ACR for migraine 1.66, 95% CI 1.31 to 2.01, for non-migraine headache 1.90, 95% CI 1.71 to 2.09 and for no headache 1.73, 95% CI 1.64 to 1.81) after relevant adjustments. Similarly, no association between headache status and ACR was seen when the analysis was stratified for morbid and random samples, or for migraine with and without aura. CONCLUSIONS: We found no evidence of increased urine albumin leakage in migraine sufferers when compared with headache-free controls. This could indicate that systemic endothelial dysfunction is not a prominent feature of migraine.  
  Address FORMI, Oslo University Hospital, Oslo, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2044-6055 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23943777; PMC3740253 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1439  
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