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Gemes, K.; Malmo, V.; Laugsand, L.E.; Loennechen, J.P.; Ellekjaer, H.; Laszlo, K.D.; Ahnve, S.; Vatten, L.J.; Mukamal, K.J.; Janszky, I. |
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Title |
Does Moderate Drinking Increase the Risk of Atrial Fibrillation? The Norwegian HUNT (Nord-Trondelag Health) Study |
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Journal Article |
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Year |
2017 |
Publication |
Journal of the American Heart Association |
Abbreviated Journal |
J Am Heart Assoc |
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Volume |
6 |
Issue |
10 |
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Keywords |
Hunt; alcohol; atrial fibrillation; cohort study; epidemiology; moderate alcohol |
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Abstract |
BACKGROUND: Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND RESULTS: Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8+/-4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%). CONCLUSIONS: Although alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population. |
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Regional Center for Health Care Improvement, St Olav's Hospital, Trondheim, Norway |
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2047-9980 |
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PMID:29054845; PMCID:PMC5721892 |
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Call Number |
HUNT @ maria.stuifbergen @ |
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1901 |
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Author |
Haug, E.B.; Horn, J.; Markovitz, A.R.; Fraser, A.; Vatten, L.J.; Macdonald-Wallis, C.; Tilling, K.; Romundstad, P.R.; Rich-Edwards, J.W.; Asvold, B.O. |
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Title |
Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway |
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Journal Article |
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Year |
2018 |
Publication |
Journal of the American Heart Association |
Abbreviated Journal |
J Am Heart Assoc |
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Volume |
7 |
Issue |
15 |
Pages |
e009250 |
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Keywords |
cardiovascular risk factors; epidemiology; hypertensive disorders of pregnancy; life course |
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Abstract |
Background Women with hypertensive pregnancy disorders have adverse levels of cardiovascular risk factors. It is unclear how this adverse risk factor profile evolves during adult life. We compared life course trajectories of cardiovascular risk factors in women with preeclampsia or gestational hypertension in their first pregnancy to normotensive women. Methods and Results We linked information on cardiovascular risk factors from the population-based HUNT (Nord-Trondelag Health Study) surveys with pregnancy information from the Medical Birth Registry of Norway. Trajectories of cardiovascular risk factors were constructed for 22 308 women with a normotensive first pregnancy; 1092 with preeclampsia, and 478 with gestational hypertension in first pregnancy. Already before first pregnancy, women with preeclampsia in their first pregnancy had higher measures of adiposity, blood pressure, heart rate, and serum lipids and glucose compared with women with a normotensive first pregnancy. After first pregnancy, there was a parallel development in cardiovascular risk factor levels, but women with a normotensive first pregnancy had a time lag of >10 years compared with the preeclampsia group. There were no clear differences in risk factor trajectories between women with gestational hypertension and women with preeclampsia. Conclusions Women with hypertensive pregnancy disorders in their first pregnancy had an adverse cardiovascular risk factor profile before pregnancy compared with normotensive women, and the differences persisted beyond 50 years of age. Hypertensive disorders in pregnancy signal long-term increases in modifiable cardiovascular risk factors, and may be used to identify women who would benefit from early prevention strategies. |
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6 Department of Endocrinology St. Olavs Hospital Trondheim University Hospital Trondheim Norway |
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2047-9980 |
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PMID:30371249; PMCID:PMC6201453 |
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Call Number |
HUNT @ maria.stuifbergen @ |
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2092 |
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