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Author Brumpton, B.; Langhammer, A.; Romundstad, P.; Chen, Y.; Mai, X.-M. url  doi
  Title General and abdominal obesity and incident asthma in adults: the HUNT study Type (up) Journal Article
  Year 2013 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 41 Issue 2 Pages 323-329  
  Keywords Adult; Asthma/*complications/*epidemiology; Body Mass Index; Female; Humans; Male; Middle Aged; Models, Statistical; Norway; Obesity/*complications/*epidemiology; Odds Ratio; Prospective Studies; Risk Factors; Smoking; Waist Circumference; Young Adult  
  Abstract Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom been investigated. To determine the association between BMI, waist circumference and incident asthma in adults, we conducted a prospective study (n=23,245) in a population living in Nord-Trondelag, Norway in 1995-2008. Baseline BMI and waist circumference were measured and categorised as general obesity (BMI >/=30.0 kg.m(2)) and abdominal obesity (waist circumference >/=88 cm in females and >/=102 cm in males). Incident asthma was self-reported new-onset cases during an 11-yr follow-up period. Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression. General obesity was a risk factor for asthma in females (OR 1.96, 95% CI 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05). Abdominal obesity seems to increase the risk of incident asthma in females in addition to BMI, indicating that using both measures of BMI and waist circumference in females may be a superior clinical assessment for asthma risk than any measure alone.  
  Address Dept. of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ben.brumpton@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22653771 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1461  
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Author Romundstad, S.; Naustdal, T.; Romundstad, P.R.; Sorger, H.; Langhammer, A. url  doi
  Title COPD and microalbuminuria: a 12-year follow-up study Type (up) Journal Article
  Year 2014 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume Issue Pages  
  Keywords  
  Abstract Chronic obstructive pulmonary disease (COPD), low lung function independent of diagnosis and markers of inflammation are all associated with increased morbidity and mortality. Microalbuminuria, reflecting endothelial dysfunction, could be a relevant inflammatory marker of potential systemic effects of COPD. We hypothesised that there was a positive association between microalbuminuria and mortality in individuals with COPD.We conducted a 12-year follow-up study of 3129 participants in the second survey of the Nord-Trondelag Health Study (HUNT), Norway. At baseline, albuminuria was analysed in three urine samples and spirometry was performed. Among the participants, 136 had COPD and microalbuminuria, defined as a urinary albumin/creatinine ratio between 2.5 and 30.0 mg.mmol-1. The main outcome measures were hazard ratio of all-cause mortality according to microalbuminuria.Compared to those with COPD without microalbuminuria, the adjusted hazard ratio for all-cause mortality in those with COPD and microalbuminuria was 1.54, 95% CI 1.16-2.04. This result was similar after excluding cardiovascular disease at baseline. Classifying COPD severity by Global Initiative for Chronic Obstructive Lung Disease, there was a positive association trend with increasing severity stages.Microalbuminuria is associated with all-cause mortality in individuals with COPD and could be a relevant tool in identification of patients with poor prognosis.  
  Address Health Trust Nord-Trondelag, Dept of Internal Medicine, Levanger  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24435009 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1502  
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Author Larose, T.L.; Langhammer, A.; Chen, Y.; Camargo, C.A.J.; Romundstad, P.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study Type (up) Journal Article
  Year 2015 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 45 Issue 4 Pages 1019-1026  
  Keywords asthma; HUNT3  
  Abstract The association between vitamin D status and lung function in adults with asthma remains unclear. We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19-55 years) with self-reported asthma in the Nord-Trondelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol.L(-1) was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (beta) and 95% confidence intervals. 44% of asthma adults had serum 25(OH)D levels <50 nmol.L(-1). Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol.L(-1) was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol.L(-1) was significantly associated with lower FEV1/FVC ratio (beta=-8.60%; 95% CI: -16.95%- -0.25%). Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25395037 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1686  
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Author Brumpton, B.; Mai, X.-M.; Langhammer, A.; Laugsand, L.E.; Janszky, I.; Strand, L.B. url  doi
  Title Prospective study of insomnia and incident asthma in adults: the HUNT study Type (up) Journal Article
  Year 2017 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 49 Issue 2 Pages  
  Keywords  
  Abstract Insomnia is highly prevalent among asthmatics; however, few studies have investigated insomnia symptoms and asthma development. We aimed to investigate the association between insomnia and the risk of incident asthma in a population-based cohort.Among 17 927 participants free from asthma at baseline we calculated odds ratios and 95% confidence intervals for the risk of incident asthma among those with insomnia compared to those without. Participants reported sleep initiation problems, sleep maintenance problems and nonrestorative sleep. Chronic insomnia was defined as those reporting one or more insomnia symptom at baseline and 10 years earlier. Incident asthma was defined by questions on asthma at baseline and follow-up (average 11 years).The prevalence of sleep initiation problems, sleep maintenance problems and nonrestorative sleep were 1%, 1% and 5%, respectively. The multi-adjusted odds ratios were 1.18 (95% CI 0.97-1.44), 1.30 (95% CI 1.03-1.64) and 1.70 (95% CI 1.37-2.11) for people with one, two and three insomnia symptoms, respectively, compared with people without symptoms (p<0.01 for trend). The risk of developing asthma in those with chronic insomnia was three times higher (adjusted OR 3.16, 95% CI 1.37-6.40) than those without.Insomnia symptoms were associated with increased risk of incident asthma in this study.  
  Address Dept of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, NTNU, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28153868 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1887  
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Author Burgel, P.-R.; Paillasseur, J.-L.; Janssens, W.; Piquet, J.; Ter Riet, G.; Garcia-Aymerich, J.; Cosio, B.; Bakke, P.; Puhan, M.A.; Langhammer, A.; Alfageme, I.; Almagro, P.; Ancochea, J.; Celli, B.R.; Casanova, C.; de-Torres, J.P.; Decramer, M.; Echazarreta, A.; Esteban, C.; Gomez Punter, R.M.; Han, M.L.K.; Johannessen, A.; Kaiser, B.; Lamprecht, B.; Lange, P.; Leivseth, L.; Marin, J.M.; Martin, F.; Martinez-Camblor, P.; Miravitlles, M.; Oga, T.; Sofia Ramirez, A.; Sin, D.D.; Sobradillo, P.; Soler-Cataluna, J.J.; Turner, A.M.; Verdu Rivera, F.J.; Soriano, J.B.; Roche, N. url  doi
  Title A simple algorithm for the identification of clinical COPD phenotypes Type (up) Journal Article
  Year 2017 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 50 Issue 5 Pages  
  Keywords  
  Abstract This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses.Data from 2409 COPD patients of French/Belgian COPD cohorts were analysed using cluster analysis resulting in the identification of subgroups, for which clinical relevance was determined by comparing 3-year all-cause mortality. Classification and regression trees (CARTs) were used to develop an algorithm for allocating patients to these subgroups. This algorithm was tested in 3651 patients from the COPD Cohorts Collaborative International Assessment (3CIA) initiative.Cluster analysis identified five subgroups of COPD patients with different clinical characteristics (especially regarding severity of respiratory disease and the presence of cardiovascular comorbidities and diabetes). The CART-based algorithm indicated that the variables relevant for patient grouping differed markedly between patients with isolated respiratory disease (FEV1, dyspnoea grade) and those with multi-morbidity (dyspnoea grade, age, FEV1 and body mass index). Application of this algorithm to the 3CIA cohorts confirmed that it identified subgroups of patients with different clinical characteristics, mortality rates (median, from 4% to 27%) and age at death (median, from 68 to 76 years).A simple algorithm, integrating respiratory characteristics and comorbidities, allowed the identification of clinically relevant COPD phenotypes.  
  Address Dept of Respiratory Medicine, Cochin Hospital, AP-HP, Paris, France  
  Corporate Author Initiatives BPCO, EABPCO, Leuven and 3CIA study groups Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29097431 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1894  
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Author Sun, Y.-Q.; Chen, Y.; Langhammer, A.; Skorpen, F.; Wu, C.; Mai, X.-M. url  doi
  Title Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study Type (up) Journal Article
  Year 2017 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 50 Issue 4 Pages  
  Keywords  
  Abstract  
  Address Dept of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29025890 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1989  
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Author Sun, Y.-Q.; Brumpton, B.M.; Bonilla, C.; Lewis, S.J.; Burgess, S.; Skorpen, F.; Chen, Y.; Nilsen, T.I.L.; Romundstad, P.R.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study Type (up) Journal Article
  Year 2018 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 51 Issue 6 Pages  
  Keywords  
  Abstract We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol.L(-1) increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.  
  Address Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29748306 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2177  
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