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Author (up) Winsvold, B.S.; Sandven, I.; Hagen, K.; Linde, M.; Midthjell, K.; Zwart, J.-A. url  doi
  Title Migraine, headache and development of metabolic syndrome: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2013 Publication Pain Abbreviated Journal Pain  
  Volume 154 Issue 8 Pages 1305-1311  
  Keywords Adult; Cardiovascular Diseases/*epidemiology; Cohort Studies; Female; Headache/diagnosis/*epidemiology; Humans; Logistic Models; Male; Metabolic Diseases/diagnosis/*epidemiology; Middle Aged; Migraine Disorders/diagnosis/*epidemiology; Norway/epidemiology; Retrospective Studies; Risk Factors; Young Adult  
  Abstract Migraine with aura is associated with an increased incidence of stroke and cardiovascular disease, but the biological mechanisms are poorly understood. This study examined the incidence of metabolic syndrome and its relationship to migraine with and without aura and to nonmigraine headache. In the population-based the Nord-Trondelag Health Study (HUNT), 19,895 individuals were followed for the development of metabolic syndrome, with a median follow-up time of 11.3 years. Headache diagnoses were based on a validated headache questionnaire, and metabolic syndrome was based on a modified version of the National Cholesterol Education Program's Adult Treatment Panel (ATP) III criteria, using objective anthropometric measurements and blood biochemistry. Using the Poisson regression model, migraine with aura was associated with an increased risk for developing metabolic syndrome. The effect was modified by smoking, with an adjusted incident risk ratio (IRR) among smokers of 2.10 (95% CI 1.53-2.89) and among nonsmokers of 1.39 (95% CI 1.03-1.86), when compared to headache-free controls. A moderate risk increase was seen for migraine without aura (IRR 1.26, 95% CI 1.12-1.42) and nonmigraine headache (IRR 1.22, 95% CI 1.13-1.32), not modified by smoking. The results suggest that traditional risk factors may be one of the mechanisms through which migraine with aura is linked to an increased risk for cardiovascular disease. A heightened vigilance concerning cardiovascular risk factors in this patient group may be warranted.  
  Address Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. b.k.winsvold@medisin.uio.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0304-3959 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23726372 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1386  
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