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Author (up) Wiedmann, M.; Brunborg, C.; Lindemann, K.; Johannesen, T.B.; Vatten, L.; Helseth, E.; Zwart, J.A. url  doi
  Title Body mass index and the risk of meningioma, glioma and schwannoma in a large prospective cohort study (The HUNT Study) Type Journal Article
  Year 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 109 Issue 1 Pages 289-294  
  Keywords Body Height; *Body Mass Index; Central Nervous System/pathology; Cohort Studies; Female; Glioma/*epidemiology; Humans; Male; Meningioma/*epidemiology; Neurilemmoma/*epidemiology; Obesity; Prospective Studies; Risk Factors; Sex Factors  
  Abstract BACKGROUND: Obesity increases the risk for a number of solid malignant tumours. However, it is not clear whether body mass index (BMI) and height are associated with the risk of primary tumours of the central nervous system (CNS). METHODS: In a large population study (The Nord-Trondelag Health Study (HUNT Study)) of 74 242 participants in Norway, weight and height were measured. During follow-up, incident CNS tumours were identified by individual linkage to the Norwegian Cancer Registry. Sex- and age-adjusted and multivariable Cox regression analyses were used to evaluate BMI and height in relation to the risk of meningioma, glioma and schwannoma. RESULTS: A total of 138 meningiomas, 148 gliomas and 39 schwannomas occurred during 23.5 years (median, range 0-25) of follow-up. In obese women (BMI >/= 30 kg m(-2)), meningioma risk was 67% higher (hazard ratio (HR)=1.68, 95% confidence interval (CI): 0.97-2.92, P-trend=0.05) than in the reference group (BMI 20-24.9 kg m(-2)), whereas no association with obesity was observed in males. There was no association of BMI with glioma risk, but there was a negative association of overweight/obesity (BMI >/= 25 kg m(-2)) with the risk of schwannoma (HR=0.48, 95% CI: 0.23-0.99). However, the schwannoma analysis was based on small numbers. Height was not associated with the risk for any tumour subgroup. CONCLUSION: These results suggest that BMI is positively associated with meningioma risk in women, and possibly, inversely associated with schwannoma risk.  
  Address Department of Neurosurgery, Oslo University Hospital, 0407 Oslo, Norway. Markus.KH.Wiedmann@gmail.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23778522; PMC3708582 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1387  
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