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Author (up) van Vliet-Ostaptchouk, J.V.; Nuotio, M.-L.; Slagter, S.N.; Doiron, D.; Fischer, K.; Foco, L.; Gaye, A.; Gogele, M.; Heier, M.; Hiekkalinna, T.; Joensuu, A.; Newby, C.; Pang, C.; Partinen, E.; Reischl, E.; Schwienbacher, C.; Tammesoo, M.-L.; Swertz, M.A.; Burton, P.; Ferretti, V.; Fortier, I.; Giepmans, L.; Harris, J.R.; Hillege, H.L.; Holmen, J.; Jula, A.; Kootstra-Ros, J.E.; Kvaloy, K.; Holmen, T.L.; Mannisto, S.; Metspalu, A.; Midthjell, K.; Murtagh, M.J.; Peters, A.; Pramstaller, P.P.; Saaristo, T.; Salomaa, V.; Stolk, R.P.; Uusitupa, M.; van der Harst, P.; Van der Klauw, M.M.; Waldenberger, M.; Perola, M.; Wolffenbuttel, B.H. url  doi
  Title The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies Type Journal Article
  Year 2014 Publication BMC Endocrine Disorders Abbreviated Journal BMC Endocr Disord  
  Volume 14 Issue 1 Pages 9  
  Keywords Harmonization; Obesity; Metabolic syndrome; Cardiovascular disease; Metabolically healthy; HUNT3  
  Abstract BACKGROUND: Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims to gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several large-scale cohort studies. Aim of this study was to describe the prevalence of obesity, metabolic syndrome (MetS) and metabolically healthy obesity (MHO) in ten participating studies. METHODS: Ten different cohorts in seven countries were combined, using data transformed into a harmonized format. All participants were of European origin, with age 18-80 years. They had participated in a clinical examination for anthropometric and blood pressure measurements. Blood samples had been drawn for analysis of lipids and glucose. Presence of MetS was assessed in those with obesity (BMI >= 30 kg/m2) based on the 2001 NCEP-ATPIII criteria, as well as an adapted set of less strict criteria. MHO was defined as obesity, having none of the MetS components, and no previous diagnosis of cardiovascular disease. RESULTS: Data for 163,517 individuals were available; 17% were obese (11,465 men and 16,612 women). The prevalence of obesity varied from 11.6% in the Italian CHRIS cohort to 26.3% in the German KORA cohort. The age-standardized percentage of obese subjects with MetS ranged in women from 24% in CHRIS to 65% in the Finnish Health2000 cohort, and in men from 43% in CHRIS to 78% in the Finnish DILGOM cohort, with elevated blood pressure the most frequently occurring factor contributing to the prevalence of the metabolic syndrome. The age-standardized prevalence of MHO varied in women from 7% in Health2000 to 28% in NCDS, and in men from 2% in DILGOM to 19% in CHRIS. MHO was more prevalent in women than in men, and decreased with age in both sexes. CONCLUSIONS: Through a rigorous harmonization process, the BioSHaRE-EU consortium was able to compare key characteristics defining the metabolically healthy obese phenotype across ten cohort studies. There is considerable variability in the prevalence of healthy obesity across the different European populations studied, even when unified criteria were used to classify this phenotype.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1472-6823 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24484869 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1391  
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