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Author (up) Sorgjerd, E.P.; Skorpen, F.; Kvaloy, K.; Midthjell, K.; Grill, V. url  doi
  Title Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway Type Journal Article
  Year 2013 Publication Autoimmunity Abbreviated Journal Autoimmunity  
  Volume 46 Issue 1 Pages 74-79  
  Keywords Age of Onset; Cation Transport Proteins/blood/genetics/*immunology; Diabetes Mellitus, Type 1/blood/epidemiology/*immunology; Female; Glutamate Decarboxylase/blood/*immunology; Humans; Male; Middle Aged; Norway/epidemiology; Phenotype; Polymorphism, Single Nucleotide; Prevalence; Receptor-Like Protein Tyrosine Phosphatases, Class 8/blood/genetics/*immunology; Statistics, Nonparametric  
  Abstract Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-onset autoimmune diabetes identified from the all-population based Nord-Trondelag health Study (HUNT) ZnT8A (assayed by a fusion probe of C-terminal Arg325 and Trp325), and antibodies against glutamic decarboxylase (GADA) and tyrosine phosphatase-like protein insulinoma antigen-2 (IA-2A) were analysed in 266 subjects classified as having adult-onset autoimmune diabetes ( >/= 25 years of age at diagnosis). Of these, 161 subjects fulfilled the criteria of latent autoimmune diabetes in adults (LADA), whereas 105 subjects were termed “classical” type 1 diabetes. Ten out of 161 LADA (6.2%) and 23 out of 105 adult-onset “classical” type 1 diabetic patients (22%) were ZnT8A positive. Adult-onset diabetic subjects positive both for GADA and IA-2A (n = 17), had lower waist circumference (p = 0.024) and higher fasting glucose levels (p = 0.023) than those positive both for GADA and ZnT8A (n = 13). Genotyping results of rs13266634 (available in 178 adult-onset diabetic subjects), showed a tendency for association between ZnT8A positivity and the TT- and CC genotypes of SNP rs13266634 (p = 0.101) using the standard cut-off level of 0.06ai, and a significant association at a lower cut-off level of 0.01ai (p = 0.005). We conclude that ZnT8A positivity in a population of adult-onset autoimmune diabetes is a less strong marker of autoimmunity than IA-2A. Further, positivity could be influenced by polymorphism of the SLC30A8 gene.  
  Address Department of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, Levanger, Norway.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0891-6934 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23061550 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1400  
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