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Author  |
Michelsen, T.M.; Dorum, A.; Cvancarova, M.; Liavaag, A.H.; Dahl, A.A. |
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Title |
Association between hysterectomy with ovarian preservation and cardiovascular disease in a Norwegian population-based sample |
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Journal Article |
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Year |
2013 |
Publication |
Gynecologic and Obstetric Investigation |
Abbreviated Journal |
Gynecol Obstet Invest |
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Volume |
75 |
Issue |
1 |
Pages |
61-67 |
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Keywords |
Aged; Antihypertensive Agents/therapeutic use; Body Mass Index; Cardiovascular Diseases/*epidemiology; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus/epidemiology; Female; Health Surveys; Hormone Replacement Therapy/utilization; Humans; Hysterectomy/*statistics & numerical data; Middle Aged; Norway/epidemiology; Ovariectomy; Prevalence; Questionnaires; Risk Factors |
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Abstract |
BACKGROUND/AIMS: Some previous studies have reported that hysterectomy predicts increased prevalence of cardiovascular diseases, but the findings are disputed. We aimed to examine associations between hysterectomy and cardiovascular disease in a Norwegian cross-sectional health study. METHODS: The data were obtained from the population-based cross-sectional Nord-Trondelag Health Study (The HUNT-2 Study). Of 46,709 invited females, 35,280 (76%) participated; 939 (3%) reported hysterectomy without oophorectomy (exposed women). Each exposed woman was age-matched with four randomly chosen women (n = 3,756) without hysterectomy or oophorectomy. Oophorectomy and hysterectomy status was self-reported by the women. Hazard ratio for cardiovascular diseases was calculated by Cox regression analyses with hysterectomy as a time-dependent covariate. RESULTS: Median time since hysterectomy was 14 years (range 0-56 years). We calculated a significantly larger cumulative probability of cardiovascular diseases after hysterectomy with a hazard ratio of 1.92, 95% CI (1.51-2.38) after adjustments for cardiovascular risk factors (diabetes, age, use of hormonal replacement therapy and positive family history of myocardial infarction). CONCLUSION: Women had a significantly increased risk of cardiovascular diseases after hysterectomy compared to age-matched controls. Studies with longitudinal design and confirmed medical outcome data are needed. |
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Address |
Section for Obstetrics, Rikshospitalet, Women and Children's Division, Oslo University Hospital Rikshospitalet, Oslo, Norway. trond.melbye.michelsen @ rikshospitalet.no |
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Language |
English |
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ISSN |
0378-7346 |
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Notes |
PMID:23220872 |
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Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
1423 |
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