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Author Michelsen, T.M.; Dorum, A.; Cvancarova, M.; Liavaag, A.H.; Dahl, A.A. url  doi
  Title Association between hysterectomy with ovarian preservation and cardiovascular disease in a Norwegian population-based sample Type Journal Article
  Year 2013 Publication Gynecologic and Obstetric Investigation Abbreviated Journal Gynecol Obstet Invest  
  Volume 75 Issue 1 Pages 61-67  
  Keywords Aged; Antihypertensive Agents/therapeutic use; Body Mass Index; Cardiovascular Diseases/*epidemiology; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus/epidemiology; Female; Health Surveys; Hormone Replacement Therapy/utilization; Humans; Hysterectomy/*statistics & numerical data; Middle Aged; Norway/epidemiology; Ovariectomy; Prevalence; Questionnaires; Risk Factors  
  Abstract BACKGROUND/AIMS: Some previous studies have reported that hysterectomy predicts increased prevalence of cardiovascular diseases, but the findings are disputed. We aimed to examine associations between hysterectomy and cardiovascular disease in a Norwegian cross-sectional health study. METHODS: The data were obtained from the population-based cross-sectional Nord-Trondelag Health Study (The HUNT-2 Study). Of 46,709 invited females, 35,280 (76%) participated; 939 (3%) reported hysterectomy without oophorectomy (exposed women). Each exposed woman was age-matched with four randomly chosen women (n = 3,756) without hysterectomy or oophorectomy. Oophorectomy and hysterectomy status was self-reported by the women. Hazard ratio for cardiovascular diseases was calculated by Cox regression analyses with hysterectomy as a time-dependent covariate. RESULTS: Median time since hysterectomy was 14 years (range 0-56 years). We calculated a significantly larger cumulative probability of cardiovascular diseases after hysterectomy with a hazard ratio of 1.92, 95% CI (1.51-2.38) after adjustments for cardiovascular risk factors (diabetes, age, use of hormonal replacement therapy and positive family history of myocardial infarction). CONCLUSION: Women had a significantly increased risk of cardiovascular diseases after hysterectomy compared to age-matched controls. Studies with longitudinal design and confirmed medical outcome data are needed.  
  Address Section for Obstetrics, Rikshospitalet, Women and Children's Division, Oslo University Hospital Rikshospitalet, Oslo, Norway. trond.melbye.michelsen @  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title (up)  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-7346 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23220872 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1423  
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