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Author (up) Lindberg, M.; Midthjell, K.; Bjerve, K.S. url  doi
  Title Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway Type Journal Article
  Year 2013 Publication The British Journal of Nutrition Abbreviated Journal Br J Nutr  
  Volume 109 Issue 6 Pages 1123-1134  
  Keywords Adult; Aged; Aged, 80 and over; Animals; Diabetes Mellitus, Type 2/*blood; *Diet; Docosahexaenoic Acids/blood; Eicosapentaenoic Acid/blood; Fatty Acids/*blood; Fatty Acids, Omega-3/administration & dosage/blood; Fatty Acids, Omega-6/blood; Female; Fishes; Humans; Male; Middle Aged; Norway; Phospholipids/*blood; *Seafood  
  Abstract Analysis of long-chain n-3 and n-6 fatty acid (FA) concentrations is used to evaluate their potential health effects in epidemiological studies, and, recently, also to counsel patients with a suboptimal intake of n-3 FA. Data on the method's ability to track and detect differences within and between individuals in appropriate populations are, however, lacking. The present study provides such data for twenty-nine plasma phospholipid (PL) FA concentrations and indices measured in 214 newly diagnosed type 2 diabetic patients at baseline and after 3 years. 20 : 3n-6 and the 20 : 4n-6:20 : 3n-6 ratio showed the highest tracking coefficients (Spearman's r 0.68), while DHA, EPA and PLN3-index (EPA+DHA) coefficients were 0.60, 0.47 and 0.55, respectively. Fish consumption measured simultaneously with EPA, DHA, sum n-3 and PLN3 index showed Spearman's correlation coefficients of 0.47, 0.44, 0.48 and 0.49, respectively, decreasing to 0.20, 0.19, 0.22 and 0.21 when measured 3 years apart. The within-subject CV of EPA, DHA and PLN3 index were 39.9, 14.3 and 18.0 %, respectively. The corresponding between-subject CV were 33.6, 16.5 and 18.7 %, while the reference change values were 112, 41 and 52 %. In conclusion, PL n-3 FA concentrations showed a significant long-term tracking and were positively correlated with marine food intake. Analytical precision, biological variability, reference change value and the index of individuality of EPA, DHA and PLN3 index are similar to commonly used clinical biomarkers, supporting their validity as dietary markers in clinical and epidemiological work.  
  Address Department of Medical Biochemistry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1145 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22846205 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1428  
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