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Author (up) Hagen, K.; Stordal, E.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title Headache as a risk factor for dementia: A prospective population-based study Type Journal Article
  Year 2013 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords Alzheimer’s disease; headache; migraine; vascular dementia  
  Abstract BACKGROUND: Headache has not been established as a risk factor for dementia. The aim of this study was to determine whether any headache was associated with subsequent development of vascular dementia (VaD), Alzheimer's disease (AD) or other types of dementia. METHODS: This prospective population-based cohort study used baseline data from the Nord-Trondelag Health Study (HUNT 2) performed during 1995-1997 and, from the same Norwegian county, a register of cases diagnosed with dementia during 1997-2010. Participants aged >/=20 years who responded to headache questions in HUNT 2 were categorized (headache free; with any headache; with migraine; with nonmigrainous headache). Hazard ratios (HRs) for later inclusion in the dementia register were estimated using Cox regression analysis. RESULTS: Of 51,383 participants providing headache data in HUNT 2, 378 appeared in the dementia register during the follow-up period. Compared to those who were headache free, participants with any headache had increased risk of VaD ( N = 63) (multivariate-adjusted HR = 2.3, 95% CI 1.4-3.8, P = 0.002) and of mixed dementia (VaD and AD ( N = 52)) (adjusted HR = 2.0, 95% CI 1.1-3.5, P = 0.018). There was no association between any headache and later development of AD ( N = 180). CONCLUSION: In this prospective population-based cohort study, any headache was a risk factor for development of VaD.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24265286 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1447  
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