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Author (up) Asberg, A.; Thorstensen, K.; Irgens, W.O.; Romundstad, P.R.; Hveem, K. url  doi
  Title Cancer risk in HFE C282Y homozygotes: results from the HUNT 2 study Type Journal Article
  Year 2013 Publication Scandinavian Journal of Gastroenterology Abbreviated Journal Scand J Gastroenterol  
  Volume 48 Issue 2 Pages 189-195  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*genetics; Carcinoma, Hepatocellular/epidemiology/*genetics; Colorectal Neoplasms/epidemiology/*genetics; Female; Follow-Up Studies; Genetic Markers; Histocompatibility Antigens Class I/*genetics; *Homozygote; Humans; Incidence; Liver Neoplasms/epidemiology/*genetics; Male; Membrane Proteins/*genetics; Middle Aged; Multivariate Analysis; Mutation; Norway/epidemiology; Proportional Hazards Models; Registries; Risk Factors  
  Abstract OBJECTIVE: In addition to hepatocellular cancer, HFE C282Y homozygotes are reported to have increased risk of colorectal cancer and breast cancer. This study was done to further explore the cancer risk in C282Y homozygotes. MATERIAL AND METHODS: We studied cancer incidence in 292 homozygotes and 62,568 others that participated in the HUNT 2 population screening in 1995-1997. Using Cox proportional hazard models, we estimated cancer hazard ratio as a function of C282Y homozygosity and several screening variables including serum transferrin saturation, alcohol consumption and daily smoking. RESULTS: Cancer was diagnosed in 36 homozygotes, five of which had two cancer diagnoses. The overall cancer incidence was not increased in C282Y homozygotes (hazard ratio 1.10 [95% CI 0.60-2.03] in women and 0.94 [95% CI 0.53-1.66] in men). However, homozygous men had increased risk of colorectal cancer (hazard ratio 3.03 [95% CI 1.17-7.82], p = 0.022) and primary liver cancer (hazard ratio 54.0 [95% CI 2.68-1089], p = 0.009). The risk of breast cancer in homozygous women was not increased (hazard ratio 1.13 [95% CI 0.35-3.72]). Adjusted for other variables including C282Y homozygosity, very low and very high serum transferrin saturation were associated with increased overall cancer incidence. CONCLUSIONS: C282Y homozygosity is associated with increased risk of colorectal cancer and hepatocellular cancer in men. In the general population, individuals with a very low or a very high serum transferrin saturation may have increased cancer risk.  
  Address Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norway. arne.aasberg@stolav.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0036-5521 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23281741 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1470  
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