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Author (up) Romundstad, S.; Naustdal, T.; Romundstad, P.R.; Sorger, H.; Langhammer, A. url  doi
  Title COPD and microalbuminuria: a 12-year follow-up study Type Journal Article
  Year 2014 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume Issue Pages  
  Keywords  
  Abstract Chronic obstructive pulmonary disease (COPD), low lung function independent of diagnosis and markers of inflammation are all associated with increased morbidity and mortality. Microalbuminuria, reflecting endothelial dysfunction, could be a relevant inflammatory marker of potential systemic effects of COPD. We hypothesised that there was a positive association between microalbuminuria and mortality in individuals with COPD.We conducted a 12-year follow-up study of 3129 participants in the second survey of the Nord-Trondelag Health Study (HUNT), Norway. At baseline, albuminuria was analysed in three urine samples and spirometry was performed. Among the participants, 136 had COPD and microalbuminuria, defined as a urinary albumin/creatinine ratio between 2.5 and 30.0 mg.mmol-1. The main outcome measures were hazard ratio of all-cause mortality according to microalbuminuria.Compared to those with COPD without microalbuminuria, the adjusted hazard ratio for all-cause mortality in those with COPD and microalbuminuria was 1.54, 95% CI 1.16-2.04. This result was similar after excluding cardiovascular disease at baseline. Classifying COPD severity by Global Initiative for Chronic Obstructive Lung Disease, there was a positive association trend with increasing severity stages.Microalbuminuria is associated with all-cause mortality in individuals with COPD and could be a relevant tool in identification of patients with poor prognosis.  
  Address Health Trust Nord-Trondelag, Dept of Internal Medicine, Levanger  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24435009 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1502  
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