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Author  |
Asberg, A.; Thorstensen, K.; Borch-Iohnsen, B. |
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Title |
Unbound iron binding capacity (UIBC) as a test for empty iron stores--results from the HUNT Study |
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Journal Article |
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Year |
2012 |
Publication |
Scandinavian Journal of Clinical and Laboratory Investigation |
Abbreviated Journal |
Scand J Clin Lab Invest |
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Volume |
72 |
Issue |
6 |
Pages |
506-509 |
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Keywords |
Adult; Area Under Curve; Chemistry, Clinical/*methods; Female; Humans; Iron/*metabolism; Middle Aged; Norway; Protein Binding; ROC Curve; Transferrin/metabolism; Young Adult |
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Abstract |
BACKGROUND: When s-iron and s-transferrin are used to diagnose empty iron stores, the measurements are usually combined in the calculation of s-transferrin saturation. This may not be the best way to utilize the information in s-iron and s-transferrin, as s-transferrin alone has a better diagnostic accuracy than s-transferrin saturation. We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores. METHODS: To test this hypothesis, we used ROC curve analysis to compare the diagnostic accuracy of s-iron, s-transferrin, s-transferrin saturation and s-UIBC in diagnosing empty iron stores in 3029 women of childbearing age. Empty iron stores were defined as s-ferritin less than 10 mug/L or less than 15 mug/L. RESULTS: At both definitions of empty iron stores s-UIBC had a better diagnostic accuracy than the other tests, with area under the ROC curve of 0.80-0.87. This was also the trend in a subpopulation of 172 anemic women, where the area under the ROC curve of s-UIBC was 0.92. CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than is calculation of s-transferrin saturation. |
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Address |
Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norway. arne.aasberg@stolav.no |
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English |
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ISSN |
0036-5513 |
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Notes |
PMID:22935044 |
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Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
1504 |
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