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Author (up) Asberg, A.; Thorstensen, K.; Borch-Iohnsen, B.
Title Unbound iron binding capacity (UIBC) as a test for empty iron stores--results from the HUNT Study Type Journal Article
Year 2012 Publication Scandinavian Journal of Clinical and Laboratory Investigation Abbreviated Journal Scand J Clin Lab Invest
Volume 72 Issue 6 Pages 506-509
Keywords Adult; Area Under Curve; Chemistry, Clinical/*methods; Female; Humans; Iron/*metabolism; Middle Aged; Norway; Protein Binding; ROC Curve; Transferrin/metabolism; Young Adult
Abstract BACKGROUND: When s-iron and s-transferrin are used to diagnose empty iron stores, the measurements are usually combined in the calculation of s-transferrin saturation. This may not be the best way to utilize the information in s-iron and s-transferrin, as s-transferrin alone has a better diagnostic accuracy than s-transferrin saturation. We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores. METHODS: To test this hypothesis, we used ROC curve analysis to compare the diagnostic accuracy of s-iron, s-transferrin, s-transferrin saturation and s-UIBC in diagnosing empty iron stores in 3029 women of childbearing age. Empty iron stores were defined as s-ferritin less than 10 mug/L or less than 15 mug/L. RESULTS: At both definitions of empty iron stores s-UIBC had a better diagnostic accuracy than the other tests, with area under the ROC curve of 0.80-0.87. This was also the trend in a subpopulation of 172 anemic women, where the area under the ROC curve of s-UIBC was 0.92. CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than is calculation of s-transferrin saturation.
Address Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norway. arne.aasberg@stolav.no
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0036-5513 ISBN Medium
Area Expedition Conference
Notes PMID:22935044 Approved no
Call Number HUNT @ maria.stuifbergen @ Serial 1504
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