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Author Asberg, A.; Thorstensen, K.; Borch-Iohnsen, B. url  doi
  Title Unbound iron binding capacity (UIBC) as a test for empty iron stores--results from the HUNT Study Type Journal Article
  Year 2012 Publication Scandinavian Journal of Clinical and Laboratory Investigation Abbreviated Journal Scand J Clin Lab Invest  
  Volume 72 Issue (up) 6 Pages 506-509  
  Keywords Adult; Area Under Curve; Chemistry, Clinical/*methods; Female; Humans; Iron/*metabolism; Middle Aged; Norway; Protein Binding; ROC Curve; Transferrin/metabolism; Young Adult  
  Abstract BACKGROUND: When s-iron and s-transferrin are used to diagnose empty iron stores, the measurements are usually combined in the calculation of s-transferrin saturation. This may not be the best way to utilize the information in s-iron and s-transferrin, as s-transferrin alone has a better diagnostic accuracy than s-transferrin saturation. We suggest that unbound iron binding capacity (UIBC), which is s-total iron binding capacity (2 times s-transferrin) minus s-iron could be used for diagnosing empty iron stores. METHODS: To test this hypothesis, we used ROC curve analysis to compare the diagnostic accuracy of s-iron, s-transferrin, s-transferrin saturation and s-UIBC in diagnosing empty iron stores in 3029 women of childbearing age. Empty iron stores were defined as s-ferritin less than 10 mug/L or less than 15 mug/L. RESULTS: At both definitions of empty iron stores s-UIBC had a better diagnostic accuracy than the other tests, with area under the ROC curve of 0.80-0.87. This was also the trend in a subpopulation of 172 anemic women, where the area under the ROC curve of s-UIBC was 0.92. CONCLUSION: When diagnosing empty iron stores calculation of s-UIBC is a better way to utilize the information in s-iron and s-transferrin than is calculation of s-transferrin saturation.  
  Address Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norway.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0036-5513 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22935044 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1504  
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