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Author (up) Bye, A.; Vettukattil, R.; Aspenes, S.T.; Giskeodegard, G.F.; Gribbestad, I.S.; Wisloff, U.; Bathen, T.F. url  doi
  Title Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study Type Journal Article
  Year 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 7 Pages e42330  
  Keywords Choline/*blood; *Exercise; Female; Humans; Male; Oxygen Consumption; Reference Values  
  Abstract BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention strategies before the individuals are diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen uptake (VO(2max)), is the single best predictor of future CVD mortality in healthy people. Based on this, we wanted to study differences between healthy individuals with a large difference in VO(2max)-level to identify new biomarkers of low aerobic fitness that may also have potential as early biomarkers of CVD risk. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples from 218 healthy individuals with a low VO(2max) (n = 108, 63 women) or high VO(2max) (n = 110, 64 women) were analysed with MR metabolomics. In addition, standard clinical-chemical analyses for glucose, lipids, liver enzymes, micro-CRP, and colorimetric analysis on circulating choline were performed. Individuals in the low VO(2max)-group had increased serum levels of free choline, decreased phosphatidylcholine, increased glucose and decreased unsaturated fatty acids compared to the individuals in the high VO(2max)-group. CONCLUSIONS/SIGNIFICANCE: Aerobic fitness dependent differences in serum levels of free choline and phosphatidylcholine are observed. They should be further studied as potential early markers of CVD risk.  
  Address Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22860113; PMC3408491 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1510  
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