toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Record Links
Author (up) Davies, S.J.C.; Bjerkeset, O.; Nutt, D.J.; Lewis, G. url  doi
  Title A U-shaped relationship between systolic blood pressure and panic symptoms: the HUNT study Type Journal Article
  Year 2012 Publication Psychological Medicine Abbreviated Journal Psychol Med  
  Volume 42 Issue 9 Pages 1969-1976  
  Keywords Anxiety Disorders/*epidemiology; *Blood Pressure; Comorbidity; Cross-Sectional Studies; Depression/epidemiology; Female; Humans; Hypertension/*epidemiology; Male; Middle Aged; Norway/epidemiology; Odds Ratio; *Panic; Panic Disorder/*epidemiology  
  Abstract BACKGROUND: Previous studies on the relationship between blood pressure (BP) and psychological morbidity are conflicting. To resolve this confusing picture we examined the hypothesis that there is a non-linear relationship between panic and systolic BP (SBP) and explored the association of generalized anxiety symptoms with SBP. Method We used data from the population-based Nord-Trondelag health study (HUNT) in which all 92 936 individuals aged >/=20 years residing in one Norwegian county were invited to participate. Panic was assessed using one item from the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS) and generalized anxiety with the remaining six items of this subscale. SBP was the mean of two measurements by an automatic device. RESULTS: A total of 64 871 respondents had SBP recorded (70%). Both unadjusted (n=61 408) and adjusted analyses provided evidence for a non-linear relationship between panic and SBP, represented by a U-shaped curve with a minimum prevalence of panic at around 140 mmHg. The relationship was strengthened after adjustment for confounders, with the quadratic term significantly associated with panic (p=0.03). Generalized anxiety symptoms were associated only with low SBP. CONCLUSIONS: The U-shaped relationship between SBP and panic provides a unifying explanation for the separate strands of published literature in this area. The results support the hypothesis that high BP and panic disorder could share brainstem autonomic and serotonergic abnormalities. By contrast, generalized anxiety symptoms were more common only at lower BPs, suggesting that any biological link between panic and high BP does not extend to generalized anxiety.  
  Address Academic Unit of Psychiatry, University of Bristol, Bristol, UK. simon.davies@bristol.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0033-2917 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22251707 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1517  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: