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Author (up) Hagen, K.; Linde, M.; Steiner, T.J.; Zwart, J.-A.; Stovner, L.J. url  doi
  Title The bidirectional relationship between headache and chronic musculoskeletal complaints: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2012 Publication European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies Abbreviated Journal Eur J Neurol  
  Volume 19 Issue 11 Pages 1447-1454  
  Keywords Cohort Studies; Female; Follow-Up Studies; Headache Disorders/*complications/*epidemiology; Humans; Male; Middle Aged; Musculoskeletal Pain/*complications/*epidemiology; Questionnaires  
  Abstract BACKGROUND AND PURPOSE: Chronic daily headache (CDH) and chronic musculoskeletal complaints (CMSCs) are associated disorders, but whether there is a causal relationship between them is unclear. OBJECTIVE: To determine whether CMSCs are associated with the subsequent development of CDH and vice versa. METHODS: This longitudinal population-based cohort study used data from two consecutive surveys in the Nord-Trondelag Health Study (HUNT 2 and 3) performed in 1995-1997 and 2006-2008. Amongst the 51 383 participants aged >/= 20 years at baseline, 41 766 were eligible approximately 11 years later. Of these, 26 197 (63%) completed the questions regarding headache and CMSCs in HUNT 3. RESULTS: A bidirectional relationship was found between headache and CMSCs. In the multivariate analyses adjusting for known potential confounders, a nearly two fold risk (OR 1.8; 95% CI 1.5-2.3) for developing CDH was found for those with CMSCs at baseline. Vice versa, a similarly elevated risk of CMSCs (OR 1.8; 95% CI 1.2-2.6), and even higher risk of chronic widespread MSCs (OR 2.7; 95% CI 1.6-4.7), was found at follow-up amongst those with CDH at baseline. CONCLUSION: CMSCs predispose to CDH and CDH predisposes to CMSCs 11 years later. This may have relevance to understanding the pathophysiology of these disorders. CMSCs should be treated not only to relieve them but also to prevent the development of CDH, and vice versa.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-5101 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22519547 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1528  
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