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Author (up) Laugsand, L.E.; Vatten, L.J.; Bjorngaard, J.H.; Hveem, K.; Janszky, I. url  doi
  Title Insomnia and high-sensitivity C-reactive protein: the HUNT study, Norway Type Journal Article
  Year 2012 Publication Psychosomatic Medicine Abbreviated Journal Psychosom Med  
  Volume 74 Issue 5 Pages 543-553  
  Keywords Adult; Age Factors; Aged; C-Reactive Protein/analysis/*metabolism; Chronic Pain/epidemiology; Coronary Disease/*epidemiology; Epidemiologic Methods; Female; Humans; Inflammation/epidemiology/*metabolism; Male; Middle Aged; Norway/epidemiology; Psychiatric Status Rating Scales; Sex Distribution; Sleep Initiation and Maintenance Disorders/*epidemiology/metabolism; Stress, Psychological/epidemiology; Young Adult  
  Abstract OBJECTIVE: To explore the hypothesis that insomnia may increase the risk of coronary heart disease through inflammatory mechanisms. METHODS: The association of high-sensitivity C-reactive protein (hsCRP) with self-reported symptoms of insomnia was examined. Participants were 8547 men and nonpregnant women who answered one or more insomnia-related questions and who had available hsCRP measurements in the Nord-Trondelag Health Study. In multivariable linear regression analyses of the logarithm of hsCRP, we adjusted for established cardiovascular risk factors, psychosocial distress, chronic pain, and chronic somatic disorders. RESULTS: Among men, difficulties initiating sleep and nonrestorative sleep were associated with increasing hsCRP levels after adjusting for age (B = 0.07, 95% confidence interval [CI] = 0.01-0.14, p for trend = .02 and B = 0.09, 95% CI = 0.02-0.15, p for trend = .006), but after multivariable adjustment, the associations were attenuated (B = 0.03, 95% CI = -0.03 to 0.09, p for trend = .30 and B = 0.06, 95% CI = -0.00 to 0.12, p for trend = .05). HsCRP was not associated with other insomnia-related symptoms. In women, there was no evidence for any association of symptoms of insomnia with hsCRP levels. Results indicated sex differences in the association between sleep characteristics and CRP (difficulties maintaining sleep, p interaction = .018; cumulative number of symptoms of insomnia, p interaction = .014; and symptoms of insomnia influencing work performance, p interaction = .039). CONCLUSIONS: There were no consistent associations between symptoms of insomnia and hsCRP levels. Our results do not support the hypothesis that inflammation, as reflected by elevated levels of hsCRP, is an important factor linking insomnia to coronary heart disease.  
  Address Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NO-7489, Norway. lars.e.laugsand@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0033-3174 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22685243 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1543  
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