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Author (up) Madssen, E.; Vatten, L.; Nilsen, T.I.; Midthjell, K.; Wiseth, R.; Dale, A.C. url  doi
  Title Abnormal glucose regulation and gender-specific risk of fatal coronary artery disease in the HUNT 1 study Type Journal Article
  Year 2012 Publication Scandinavian Cardiovascular Journal : SCJ Abbreviated Journal Scand Cardiovasc J  
  Volume 46 Issue 4 Pages 219-225  
  Keywords Aged; Blood Glucose/*metabolism; Confidence Intervals; Coronary Artery Disease/epidemiology/metabolism/*mortality; Diabetes Mellitus/metabolism; Female; Health Status Indicators; Humans; Male; Middle Aged; Norway; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment/methods; Sex Factors  
  Abstract OBJECTIVES: To assess fatal coronary artery disease (CAD) by gender and glucose regulation status. DESIGN: 47,951 people were followed up according to fatal CAD identified in the National Cause of Death Registry. Gender-effects of fatal CAD in people with impaired glucose regulation (IGR), newly diagnosed diabetes (NDM) or known diabetes (KDM) compared with people with normal glucose regulation (NGR) were calculated using Cox regression. RESULTS: Using NGR as reference, the hazard ratios (HR, 95% confidence intervals) associated with IGR was 1.2 (0.8-1.9) for women and 1.2 (0.9-1.6) for men. The corresponding HRs were 1.6 (1.2-2.2) and 1.4 (1.1.-1.9) for NDM, and 2.5 (2.1-2.8) and 1.8 (1.6-2.1) for KDM. The gender-difference in mortality varied by category (P(interaction) = 0.003). Using women as the reference, the HRs for men were 2.1 (2.0-2.3) for NGR, 1.8 (1.0-3.3) for IGR, 1.6 (1.0-2.5) for NDM, and 1.2 (1.0-1.5) for KDM. CONCLUSIONS: Diabetes mellitus, but not IGR, was associated with fatal CAD in both genders. The known gender-difference in CAD mortality was attenuated in people with abnormal glucose regulation, evident already in people with IGR.  
  Address Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1401-7431 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22303857 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1549  
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