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Author (up) Mai, X.-M.; Langhammer, A.; Camargo, C.A.J.; Chen, Y. url  doi
  Title Serum 25-hydroxyvitamin D levels and incident asthma in adults: the HUNT Study Type Journal Article
  Year 2012 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 176 Issue 12 Pages 1169-1176  
  Keywords Adult; Asthma/*epidemiology; Case-Control Studies; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Norway/epidemiology; Prospective Studies; Rhinitis, Allergic, Perennial/epidemiology; Risk Factors; Sex Distribution; Vitamin D/*analogs & derivatives/blood; Vitamin D Deficiency/*epidemiology  
  Abstract The impact of low vitamin D status on asthma development is unclear. The authors investigated the relation between the baseline serum 25-hydroxyvitamin D (25(OH)D) level and incident asthma in adults, including possible effect modification by allergy status, using allergic rhinitis as a proxy measure. A cohort of 25,616 Norwegian adults aged 19-55 years participated in 2 surveys of the Nord-Trondelag Health Study known as HUNT 2 (1995-1997) and HUNT 3 (2006-2008). Of this cohort, a nested case-control study included 584 new-onset asthma cases and 1,958 nonasthma controls whose baseline serum 25(OH)D levels were measured. After adjustment for potential asthma risk factors, the baseline serum level of 25(OH)D (<50 nmol/L) was not significantly associated with asthma in either women (adjusted odds ratio = 0.94, 95% confidence interval (CI): 0.67, 1.32) or men (adjusted odds ratio = 1.47, 95% CI: 0.93, 2.32). In men, allergic rhinitis modified the association with the adjusted odds ratio being 0.87 (95% CI: 0.36, 2.06) among men with allergic rhinitis and 2.32 (95% CI: 1.06, 5.10) among men without allergic rhinitis. The serum 25(OH)D level was not associated with incident asthma in women, regardless of allergy status. Low vitamin D status was not significantly associated with incident asthma in most adults, but it may have increased risk among men without allergy.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. xiao-mei.mai@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9262 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23204497 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1552  
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