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Author (up) Sandvei, M.S.; Lindekleiv, H.; Romundstad, P.R.; Muller, T.B.; Vatten, L.J.; Ingebrigtsen, T.; Njolstad, I.; Mathiesen, E.B.; Vik, A. url  doi
  Title Risk factors for aneurysmal subarachnoid hemorrhage – BMI and serum lipids: 11-year follow-up of the HUNT and the Tromso Study in Norway Type Journal Article
  Year 2012 Publication Acta Neurologica Scandinavica Abbreviated Journal Acta Neurol Scand  
  Volume 125 Issue 6 Pages 382-388  
  Keywords Adult; Age Factors; Aged; Aged, 80 and over; *Body Mass Index; Cohort Studies; Female; Follow-Up Studies; Humans; Lipids/*blood; Male; Middle Aged; Norway/epidemiology; Overweight; Prospective Studies; Questionnaires; Risk Factors; Subarachnoid Hemorrhage/*blood/diagnosis/*epidemiology  
  Abstract OBJECTIVES: Life-style factors have been associated with the risk for aneurysmal subarachnoid hemorrhage (aSAH), but it is not clear whether body mass index (BMI) and serum lipids are associated with risk. We prospectively assessed these associations in two large population studies. METHODS: A total of 65,526 participants in the Nord-Trondelag Health Study (1995-1997) and 26,882 participants in the Tromso Study (1994-1995) were included. Studies included measurements of body weight and height, serum lipids, and self-administered questionnaires. Participants who experienced aSAH were identified, and hazard ratios (HRs) were estimated using Cox regression analysis. RESULTS: During 11 years of follow-up, aSAH was diagnosed in 122 participants. Overweight (BMI 25-29.9) was negatively associated with the risk of aSAH (HR 0.7, 95% CI 0.4-1.0). There was no over all association of total serum cholesterol, HDL cholesterol, or triglycerides with the risk of aSAH, but in participants younger than 50 years, HDL cholesterol was inversely associated with the risk (HR per standard deviation increase 0.6, 95% CI 0.4-0.9). CONCLUSIONS: Overweight may be associated with reduced risk of aSAH, but there was no over all association of total serum cholesterol, HDL cholesterol, or triglycerides with the risk of aSAH in this prospective study.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. marie.s.sandvei@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0001-6314 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21793808 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1573  
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