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Author (up) Strand, L.B.; Laugsand, L.E.; Skaug, E.-A.; Ellingsen, O.; Madssen, E.; Wisloff, U.; Vatten, L.; Janszky, I. url  doi
  Title Insomnia and endothelial function – the HUNT 3 fitness study Type Journal Article
  Year 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 12 Pages e50933  
  Keywords Adult; Aged; Brachial Artery/*physiopathology; Endothelium, Vascular/*physiopathology; Female; Health Status; Humans; Male; Middle Aged; Norway; Questionnaires; Sleep Initiation and Maintenance Disorders/*physiopathology  
  Abstract BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. linn.b.strand@ntnu.no  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23236412; PMC3516514 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1580  
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