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Author (up) Laugsand, L.E.; Strand, L.B.; Platou, C.; Vatten, L.J.; Janszky, I. url  doi
  Title Insomnia and the risk of incident heart failure: a population study Type Journal Article
  Year 2014 Publication European Heart Journal Abbreviated Journal Eur Heart J  
  Volume 35 Issue 21 Pages 1382-1393  
  Keywords Heart failure; Insomnia; Prospective study; HUNT2  
  Abstract AIMS: Insomnia is highly prevalent among heart failure patients, but only a few small studies have investigated insomnia symptoms and risk of heart failure. We aimed to assess the prospective association between self-reported insomnia symptoms and the risk of incident heart failure in a large Norwegian cohort. METHODS AND RESULTS: Baseline data on insomnia symptoms, including difficulty initiating sleep, difficulty maintaining sleep and having non-restorative sleep, socio-demographic variables, and health status, including established cardiovascular risk factors, were collected from 54 279 men and women 20-89 years of age who participated in the Nord-Trondelag Health study (HUNT) between 1995 and 1997 and were free from known heart failure at baseline. The cohort was followed for incident heart failure from baseline through 2008. We used Cox proportional hazard models to assess the association of baseline insomnia symptoms with the risk of heart failure. A total of 1412 cases of heart failure occurred during a mean follow-up of 11.3 years (SD = 2.9 years), either identified at hospitals or by the National Cause of Death Registry. There was a dose-dependent association between the number of insomnia symptoms and risk of heart failure. The multi-adjusted hazard ratios were 0.96 (0.57-1.61), 1.35 (0.72-2.50), and 4.53 (1.99-10.31) for people with one, two, and three insomnia symptoms, compared with people with none of the symptoms (P for trend 0.021). CONCLUSIONS: Insomnia is associated with an increased risk of incident heart failure. If our results are confirmed by others and causation is proved, evaluation of insomnia symptoms might have consequences for cardiovascular prevention.  
  Address Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, NTNU, Trondheim N-7491, Norway Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0195-668X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23462728 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1619  
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