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Author (up) Iversen, M.M.; Tell, G.S.; Espehaug, B.; Midthjell, K.; Graue, M.; Rokne, B.; Berge, L.I.; Ostbye, T. url  doi
  Title Is depression a risk factor for diabetic foot ulcers? 11-years follow-up of the Nord-Trondelag Health Study (HUNT) Type Journal Article
  Year 2014 Publication Journal of Diabetes and its Complications Abbreviated Journal J Diabetes Complications  
  Volume Issue Pages  
  Keywords HUNT2; Cohort study; Depression; Diabetes; Foot ulcer; Norway; Risk factor  
  Abstract AIM: To prospectively examine whether depressive symptoms increase the risk of diabetes and a diabetic foot ulcer. METHODS: The Nord-Trondelag Health Study (HUNT) is a community-based longitudinal study. The Hospital Anxiety and Depression Scale (HADS-D subscale) assessed depressive symptoms. We followed individuals with complete HADS-D data from HUNT2 (1995-97) and assessed whether they reported diabetes with or without a history of diabetic foot ulcer (DFU) in HUNT3 (2006-08) (n=36,031). Logistic regression was used to investigate the effect of depressive symptoms on subsequent development of diabetes and of DFU. RESULTS: Unadjusted odds for reporting diabetes at follow-up was higher among individuals who reported a HADS-D score>/=8 at baseline (OR 1.30 95% CI, 1.07-1.57) than among those reporting a lower score. After adjusting for age, gender and BMI, this association was no longer significant. The odds of developing a DFU was almost two-fold (OR=1.95 95% CI, 1.02-3.74) for those reporting a HADS-D score of 8-10, and 3-fold (OR=3.06 95% CI, 1.24-7.54) for HADS-D scores>/=11, compared to HADS-D scores<8, after adjusting for age, gender and serum glucose. CONCLUSIONS: Symptoms of depression at baseline are associated with an increased risk of a diabetic foot ulcer in a dose response manner during this 11-year follow-up.  
  Address Duke Global Health Institute, Duke University, Box 90519 Durham, NC 27708, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1056-8727 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25283486 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1648  
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