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Author (up) Moe, B.; Nilsen, T.I.L. url  doi
  Title Cancer risk in people with diabetes: does physical activity and adiposity modify the association? Prospective data from the HUNT Study, Norway Type Journal Article
  Year 2014 Publication Journal of Diabetes and its Complications Abbreviated Journal J Diabetes Complications  
  Volume Issue Pages  
  Keywords Body mass index; Cancer risk; Diabetes; Epidemiology; Leisure time physical exercise; HUNT1  
  Abstract AIMS: To examine whether physical activity and adiposity modify the increased risk of cancer associated with diabetes. METHODS: We prospectively examined the association of diabetes and risk of cancer among 73,726 persons stratified by physical activity and body mass index (BMI). Adjusted hazard ratios (HRs) with 95% confidence intervals (CI) were estimated from Cox regression. RESULTS: During a median follow-up of 22.0years, 9572 people were diagnosed with incident cancer. There was no clear association between diabetes and cancer risk in those reporting high levels of physical activity (>/=2.0h per week) (HR 0.93; 95% CI: 0.70-1.24) or those with a normal weight (BMI <25kg/m2) (HR 1.02; 95% CI: 0.84-1.25). However, among people with diabetes who reported low levels of physical activity (<2.0h per week), diabetes was associated with an HR of 1.15 (95% CI: 1.01-1.31). Correspondingly, diabetes was associated with an HR of 1.21 (95% CI: 1.07-1.37) among overweight or obese people (BMI >/=25kg/m2). CONCLUSIONS: There was evidence that the increased risk of cancer associated with diabetes was confined to persons who reported low levels of physical activity, or who were overweight or obese.  
  Address Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1056-8727 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25534878 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1659  
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