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Author (up) Vik, K.L.; Romundstad, P.; Carslake, D.; Davey Smith, G.; Nilsen, T.I. url  doi
  Title Transgenerational effects of parental cardiovascular disease and risk factors on offspring mortality: family-linkage data from the HUNT Study, Norway Type Journal Article
  Year 2014 Publication European Journal of Preventive Cardiology Abbreviated Journal Eur J Prev Cardiol  
  Volume Issue Pages  
  Keywords HUNT1; HUNT2; HUNT3; Epidemiology; cardiovascular diseases; intergenerational relations; risk factors  
  Abstract BACKGROUND: Cardiovascular risk factors are known to be associated between parents and offspring. However, whether these associations are reflected in increased offspring mortality has not been extensively studied. DESIGN: This was a family study of 32,536 father-offspring and 39,614 mother-offspring pairs who participated in the HUNT Study, Norway. METHODS: Adjusted hazard ratios (HRs) for offspring total and cardiovascular mortality associated with parental levels of cardiovascular disease risk factors were estimated using Cox regression. RESULTS AND CONCLUSIONS: Fathers' and mothers' reporting of cardiovascular disease (HRs: 1.18; 95% CI 1.04-1.32 and 1.20; 1.07-1.35, respectively), diabetes (HRs: 1.22; 95% CI 1.00-1.49 and 1.21; 1.05-1.40, respectively), and current smoking (HRs: 1.21; 95% CI 1.08-1.36 and 1.30; 1.15-1.47, respectively) was associated with total mortality in offspring. An inverse association was found with maternal height (HR: 0.95; 95% CI 0.91-0.99), and a suggestive inverse association with paternal height (HR: 0.98; 95% CI 0.93-1.03). Relations with offspring cardiovascular mortality were less clear and consistent. Offspring whose parents both had a risk factor did not seem to have higher mortality than would be expected from the independent effects of each parent.  
  Address Department of Public Health, Norwegian University of Science and Technology, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2047-4873 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25425350 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1667  
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