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Author  |
Vik, K.L.; Romundstad, P.; Carslake, D.; Davey Smith, G.; Nilsen, T.I. |
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Title |
Transgenerational effects of parental cardiovascular disease and risk factors on offspring mortality: family-linkage data from the HUNT Study, Norway |
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Journal Article |
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Year |
2014 |
Publication |
European Journal of Preventive Cardiology |
Abbreviated Journal |
Eur J Prev Cardiol |
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Keywords |
HUNT1; HUNT2; HUNT3; Epidemiology; cardiovascular diseases; intergenerational relations; risk factors |
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Abstract |
BACKGROUND: Cardiovascular risk factors are known to be associated between parents and offspring. However, whether these associations are reflected in increased offspring mortality has not been extensively studied. DESIGN: This was a family study of 32,536 father-offspring and 39,614 mother-offspring pairs who participated in the HUNT Study, Norway. METHODS: Adjusted hazard ratios (HRs) for offspring total and cardiovascular mortality associated with parental levels of cardiovascular disease risk factors were estimated using Cox regression. RESULTS AND CONCLUSIONS: Fathers' and mothers' reporting of cardiovascular disease (HRs: 1.18; 95% CI 1.04-1.32 and 1.20; 1.07-1.35, respectively), diabetes (HRs: 1.22; 95% CI 1.00-1.49 and 1.21; 1.05-1.40, respectively), and current smoking (HRs: 1.21; 95% CI 1.08-1.36 and 1.30; 1.15-1.47, respectively) was associated with total mortality in offspring. An inverse association was found with maternal height (HR: 0.95; 95% CI 0.91-0.99), and a suggestive inverse association with paternal height (HR: 0.98; 95% CI 0.93-1.03). Relations with offspring cardiovascular mortality were less clear and consistent. Offspring whose parents both had a risk factor did not seem to have higher mortality than would be expected from the independent effects of each parent. |
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Address |
Department of Public Health, Norwegian University of Science and Technology, Norway |
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Language |
English |
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Original Title |
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Series Volume |
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Edition |
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ISSN |
2047-4873 |
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Notes |
PMID:25425350 |
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Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
1667 |
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