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Author (up) Larose, T.L.; Langhammer, A.; Chen, Y.; Camargo, C.A.J.; Romundstad, P.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study Type Journal Article
  Year 2015 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 45 Issue 4 Pages 1019-1026  
  Keywords asthma; HUNT3  
  Abstract The association between vitamin D status and lung function in adults with asthma remains unclear. We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19-55 years) with self-reported asthma in the Nord-Trondelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol.L(-1) was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (beta) and 95% confidence intervals. 44% of asthma adults had serum 25(OH)D levels <50 nmol.L(-1). Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol.L(-1) was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol.L(-1) was significantly associated with lower FEV1/FVC ratio (beta=-8.60%; 95% CI: -16.95%- -0.25%). Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.  
  Address Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25395037 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1686  
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