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Author (up) Purdue, M.P.; Johansson, M.; Zelenika, D.; Toro, J.R.; Scelo, G.; Moore, L.E.; Prokhortchouk, E.; Wu, X.; Kiemeney, L.A.; Gaborieau, V.; Jacobs, K.B.; Chow, W.-H.; Zaridze, D.; Matveev, V.; Lubinski, J.; Trubicka, J.; Szeszenia-Dabrowska, N.; Lissowska, J.; Rudnai, P.; Fabianova, E.; Bucur, A.; Bencko, V.; Foretova, L.; Janout, V.; Boffetta, P.; Colt, J.S.; Davis, F.G.; Schwartz, K.L.; Banks, R.E.; Selby, P.J.; Harnden, P.; Berg, C.D.; Hsing, A.W.; Grubb, R.L. 3rd; Boeing, H.; Vineis, P.; Clavel-Chapelon, F.; Palli, D.; Tumino, R.; Krogh, V.; Panico, S.; Duell, E.J.; Quiros, J.R.; Sanchez, M.-J.; Navarro, C.; Ardanaz, E.; Dorronsoro, M.; Khaw, K.-T.; Allen, N.E.; Bueno-de-Mesquita, H.B.; Peeters, P.H.M.; Trichopoulos, D.; Linseisen, J.; Ljungberg, B.; Overvad, K.; Tjonneland, A.; Romieu, I.; Riboli, E.; Mukeria, A.; Shangina, O.; Stevens, V.L.; Thun, M.J.; Diver, W.R.; Gapstur, S.M.; Pharoah, P.D.; Easton, D.F.; Albanes, D.; Weinstein, S.J.; Virtamo, J.; Vatten, L.; Hveem, K.; Njolstad, I.; Tell, G.S.; Stoltenberg, C.; Kumar, R.; Koppova, K.; Cussenot, O.; Benhamou, S.; Oosterwijk, E.; Vermeulen, S.H.; Aben, K.K.H.; van der Marel, S.L.; Ye, Y.; Wood, C.G.; Pu, X.; Mazur, A.M.; Boulygina, E.S.; Chekanov, N.N.; Foglio, M.; Lechner, D.; Gut, I.; Heath, S.; Blanche, H.; Hutchinson, A.; Thomas, G.; Wang, Z.; Yeager, M.; Fraumeni, J.F.J.; Skryabin, K.G.; McKay, J.D.; Rothman, N.; Chanock, S.J.; Lathrop, M.; Brennan, P. url  doi
  Title Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3 Type Journal Article
  Year 2011 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 43 Issue 1 Pages 60-65  
  Keywords HUNT2; Carcinoma, Renal Cell/*genetics; Case-Control Studies; Chromosomes, Human, Pair 11/*genetics; Chromosomes, Human, Pair 2/*genetics; *Genetic Predisposition to Disease/genetics; Genome, Human; *Genome-Wide Association Study; Humans; Kidney Neoplasms/*genetics; Polymorphism, Single Nucleotide; Risk Factors  
  Abstract We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10(-)(8)) and rs7579899 (P = 2.3 x 10(-)(9)), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(-)(1)(4)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10(-)(8)). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.  
  Address Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21131975; PMC3049257 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1697  
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