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Author (up) Husoy, A.K.; Indergaard, M.K.; Honningsvag, L.-M.; Haberg, A.K.; Hagen, K.; Linde, M.; Garseth, M.; Stovner, L.J. url  doi
  Title Perivascular spaces and headache: A population-based imaging study (HUNT-MRI) Type Journal Article
  Year 2015 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume Issue Pages  
  Keywords HUNT1; HUNT2; HUNT3; Virchow-Robin spaces; epidemiology; headache; magnetic resonance imaging; migraine; population-based  
  Abstract BACKGROUND: In four previous clinic-based MRI studies headache sufferers (in particular migraineurs) had more perivascular spaces (PVS) than individuals who were headache-free. METHODS: The present study was part of a large longitudinal, epidemiological study (Nord-Trondelag Health Survey (HUNT)). The 1006 participants, age 50-65 years at inclusion, had participated in all previous HUNT surveys (1-3), and been randomly selected to a population-based imaging study of the head (HUNT-MRI, 2007-2009). The number of visible PVS in the basal ganglia (BG) and hemispheric white matter (HWM) was compared in headache sufferers (migraine with and without aura, non-migrainous headache) and people who were headache-free. RESULTS: The results showed in general small differences between headache sufferers and headache-free participants. In the cross-sectional analysis migraineurs without aura had fewer PVS than headache-free individuals in BG (OR = 0.84, 95% CI = 0.76--0.94, p value = 0.003) and in BG and HWM together (OR = 0.97, 95% CI = 0.95-1.00, p value = 0.046). No difference between long-term headache sufferers and long-term headache-free individuals with regard to number of PVS was found. DISCUSSION: In contrast to previous studies, the present large, blinded, population-based study showed no increase in number of dilated PVS among headache sufferers. Fewer PVS among those with migraine without aura may be a spurious finding.  
  Address Department of Neuroscience, Norwegian University of Science and Technology, Norway Norwegian National Headache Centre, St Olavs University Hospital, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0333-1024 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26024925 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1699  
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