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Author (up) Helgeland, O.; Hertel, J.K.; Molven, A.; Raeder, H.; Platou, C.G.P.; Midthjell, K.; Hveem, K.; Nygard, O.; Njolstad, P.R.; Johansson, S. url  doi
  Title The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) Type Journal Article
  Year 2015 Publication International Journal of Endocrinology Abbreviated Journal Int J Endocrinol  
  Volume 2015 Issue Pages 164652  
  Keywords HUNT2  
  Abstract Background. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2. Results. Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282mid R:rs10811661: OR = 1.19, P = 2.0 x 10(-3)) in the region. We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD (P < 0.01). Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501 (P = 0.03) and rs3217986 (P = 0.04). Conclusions. We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region.  
  Address KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway ; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-8337 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26089876; PMC4451520 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 1714  
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