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Author (up) Askim, A.; Mehl, A.; Paulsen, J.; DeWan, A.T.; Vestrheim, D.F.; Asvold, B.O.; Damas, J.K.; Solligard, E.   
  Title Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993-2011: an observational study Type Journal Article
  Year 2016 Publication BMC Infect Dis Abbreviated Journal BMC infectious diseases  
  Volume 16 Issue 1 Pages 223  
  Abstract BACKGROUND: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trondelag county in Norway from 1993 to 2011 to study the clinical variables and disease outcome. The main outcome was all-cause mortality after 30 and 90 days. METHODS: Patients with positive blood cultures were registered prospectively by the microbiology laboratory and clinical variables were registered retrospectively from patients' hospital records. The severity of sepsis was assigned according to the 2001 International Sepsis Definition Conference criteria. The association between mortality and predictive factors was studied using a logistic regression model. RESULTS: The total number of patients was 414 with mean age of 67 years and 53 % were male. Comorbidity was assessed by the Charlson Comorbidity Index (CCI). A CCI-score of 0 was registered in 144 patients (34.8 %), whereas 190 had a score of 1-2 (45.9 %) and 80 (19.3 %) had a score >/=3. 68.8 % of the patients received appropriate antibiotics within the first 6 h. The 30-day mortality risk increased by age and was 3-fold higher for patients aged >/=80 years (24.9, 95 % CI 16.4-33.4 %) compared to patients aged  
  Corporate Author Thesis  
  Publisher Place of Publication Clinic of Anaesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway. asa.askim@ Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Askim2016 Serial 1730  
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