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Author (up) Omland, T.; de Lemos, J.A.; Holmen, O.L.; Dalen, H.; Benth, J.S.; Nygard, S.; Hveem, K.; Rosjo, H.   
  Title Impact of Sex on the Prognostic Value of High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study Type Journal Article
  Year 2015 Publication Clin Chem Abbreviated Journal Clinical chemistry  
  Volume 61 Issue 4 Pages 646-656  
  Keywords HUNT3; Adult; Aged; Aged, 80 and over; Biomarkers/blood; Cardiovascular Diseases/*mortality; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Norway/epidemiology; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; ROC Curve; Sex Factors; Troponin I/*blood; Young Adult  
  Abstract BACKGROUND: A new, high-sensitivity assay for cardiac troponin I (hs-cTnI)11 permits evaluation of the prognostic value of cardiac troponins within the reference interval. Men have higher hs-cTnI concentrations than women, but the underlying pathophysiological mechanisms and prognostic implications are unclear. The aim of this study was to assess the potential impact of sex on the association between hs-cTnI and cardiovascular death. METHODS: By use of the Architect STAT High-Sensitive Troponin assay, we measured hs-cTnI in 4431 men and 5281 women aged >/=20 years participating in the prospective observational Nord-Trondelag Health Study (HUNT). RESULTS: hs-cTnI was detectable in 98.5% of men and 94.7% of women. During a mean follow-up period of 13.9 years, 708 cardiovascular deaths were registered. hs-cTnI was associated with the incidence of cardiovascular death [adjusted hazard ratio (HR) per 1 SD in log hs-cTnI 1.23 (95% CI 1.15-1.31)], with higher relative risk in women than men [HR 1.44 (1.31-1.58) vs 1.10 (1.00-1.20); Pinteraction  
  Corporate Author Thesis  
  Publisher Place of Publication Division of Medicine and Center for Heart Failure Research and K.G. Jebsen Cardiac Research Centre a Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Omland2015 Serial 1851  
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