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Author (up) Shungin, D.; Winkler, T.W.; Croteau-Chonka, D.C.; Ferreira, T.; Locke, A.E.; Magi, R.; Strawbridge, R.J.; Pers, T.H.; Fischer, K.; Justice, A.E.; Workalemahu, T.; Wu, J.M.; Buchkovich, M.L.; Heard-Costa, N.L.; Roman, T.S.; Drong, A.W.; Song, C.; Gustafsson, S.; Day, F.R.; Esko, T.; Fall, T.; Kutalik, Z.; Luan, J.; Randall, J.C.; Scherag, A.; Vedantam, S.; Wood, A.R.; Chen, J.; Fehrmann, R.; Karjalainen, J.; Kahali, B.; Liu, C.T.; Schmidt, E.M.; Absher, D.; Amin, N.; Anderson, D.; Beekman, M.; Bragg-Gresham, J.L.; Buyske, S.; Demirkan, A.; Ehret, G.B.; Feitosa, M.F.; Goel, A.; Jackson, A.U.; Johnson, T.; Kleber, M.E.; Kristiansson, K.; Mangino, M.; Mateo Leach, I.; Medina-Gomez, C.; Palmer, C.D.; Pasko, D.; Pechlivanis, S.; Peters, M.J.; Prokopenko, I.; Stancakova, A.; Ju Sung, Y.; Tanaka, T.; Teumer, A.; Van Vliet-Ostaptchouk, J.V.; Yengo, L.; Zhang, W.; Albrecht, E.; Arnlov, J.; Arscott, G.M.; Bandinelli, S.; Barrett, A.; Bellis, C.; Bennett, A.J.; Berne, C.; Bluher, M.; Bohringer, S.; Bonnet, F.; Bottcher, Y.; Bruinenberg, M.; Carba, D.B.; Caspersen, I.H.; Clarke, R.; Daw, E.W.; Deelen, J.; Deelman, E.; Delgado, G.; Doney, A.S.; Eklund, N.; Erdos, M.R.; Estrada, K.; Eury, E.; Friedrich, N.; Garcia, M.E.; Giedraitis, V.; Gigante, B.; Go, A.S.; Golay, A.; Grallert, H.; Grammer, T.B.; Grassler, J.; Grewal, J.; Groves, C.J.; Haller, T.; Hallmans, G.; Hartman, C.A.; Hassinen, M.; Hayward, C.; Heikkila, K.; Herzig, K.H.; Helmer, Q.; Hillege, H.L.; Holmen, O.; Hunt, S.C.; Isaacs, A.; Ittermann, T.; James, A.L.; Johansson, I.; Juliusdottir, T.; Kalafati, I.P.; Kinnunen, L.; Koenig, W.; Kooner, I.K.; Kratzer, W.; Lamina, C.; Leander, K.; Lee, N.R.; Lichtner, P.; Lind, L.; Lindstrom, J.; Lobbens, S.; Lorentzon, M.; Mach, F.; Magnusson, P.K.; Mahajan, A.; McArdle, W.L.; Menni, C.; Merger, S.; Mihailov, E.; Milani, L.; Mills, R.; Moayyeri, A.; Monda, K.L.; Mooijaart, S.P.; Muhleisen, T.W.; Mulas, A.; Muller, G.; Muller-Nurasyid, M.; Nagaraja, R.; Nalls, M.A.; Narisu, N.; Glorioso, N.; Nolte, I.M.; Olden, M.; Rayner, N.W.; Renstrom, F.; Ried, J.S.; Robertson, N.R.; Rose, L.M.; Sanna, S.; Scharnagl, H.; Scholtens, S.; Sennblad, B.; Seufferlein, T.; Sitlani, C.M.; Vernon Smith, A.; Stirrups, K.; Stringham, H.M.; Sundstrom, J.; Swertz, M.A.; Swift, A.J.; Syvanen, A.C.; Tayo, B.O.; Thorand, B.; Thorleifsson, G.; Tomaschitz, A.; Troffa, C.; van Oort, F.V.; Verweij, N.; Vonk, J.M.; Waite, L.L.; Wennauer, R.; Wilsgaard, T.; Wojczynski, M.K.; Wong, A.; Zhang, Q.; Hua Zhao, J.; Brennan, E.P.; Choi, M.; Eriksson, P.; Folkersen, L.; Franco-Cereceda, A.; Gharavi, A.G.; Hedman, A.K.; Hivert, M.F.; Huang, J.; Kanoni, S.; Karpe, F.; Keildson, S.; Kiryluk, K.; Liang, L.; Lifton, R.P.; Ma, B.; McKnight, A.J.; McPherson, R.; Metspalu, A.; Min, J.L.; Moffatt, M.F.; Montgomery, G.W.; Murabito, J.M.; Nicholson, G.; Nyholt, D.R.; Olsson, C.; Perry, J.R.; Reinmaa, E.; Salem, R.M.; Sandholm, N.; Schadt, E.E.; Scott, R.A.; Stolk, L.; Vallejo, E.E.; Westra, H.J.; Zondervan, K.T.; Consortium, A.D.I.P.O.G.; Consortium, C.A.R.D.I.O.G.R.A.M.C.4D.; Consortium, C.K.D.G.; Consortium, G.; Consortium, G.; Glgc; Icbp; International Endogene, C.; LifeLines Cohort, S.; Investigators, M.; Mu, T.C.; Consortium, P.; ReproGen, C.; Amouyel, P.; Arveiler, D.; Bakker, S.J.; Beilby, J.; Bergman, R.N.; Blangero, J.; Brown, M.J.; Burnier, M.; Campbell, H.; Chakravarti, A.; Chines, P.S.; Claudi-Boehm, S.; Collins, F.S.; Crawford, D.C.; Danesh, J.; de Faire, U.; de Geus, E.J.; Dorr, M.; Erbel, R.; Eriksson, J.G.; Farrall, M.; Ferrannini, E.; Ferrieres, J.; Forouhi, N.G.; Forrester, T.; Franco, O.H.; Gansevoort, R.T.; Gieger, C.; Gudnason, V.; Haiman, C.A.; Harris, T.B.; Hattersley, A.T.; Heliovaara, M.; Hicks, A.A.; Hingorani, A.D.; Hoffmann, W.; Hofman, A.; Homuth, G.; Humphries, S.E.; Hypponen, E.; Illig, T.; Jarvelin, M.R.; Johansen, B.; Jousilahti, P.; Jula, A.M.; Kaprio, J.; Kee, F.; Keinanen-Kiukaanniemi, S.M.; Kooner, J.S.; Kooperberg, C.; Kovacs, P.; Kraja, A.T.; Kumari, M.; Kuulasmaa, K.; Kuusisto, J.; Lakka, T.A.; Langenberg, C.; Le Marchand, L.; Lehtimaki, T.; Lyssenko, V.; Mannisto, S.; Marette, A.; Matise, T.C.; McKenzie, C.A.; McKnight, B.; Musk, A.W.; Mohlenkamp, S.; Morris, A.D.; Nelis, M.; Ohlsson, C.; Oldehinkel, A.J.; Ong, K.K.; Palmer, L.J.; Penninx, B.W.; Peters, A.; Pramstaller, P.P.; Raitakari, O.T.; Rankinen, T.; Rao, D.C.; Rice, T.K.; Ridker, P.M.; Ritchie, M.D.; Rudan, I.; Salomaa, V.; Samani, N.J.; Saramies, J.; Sarzynski, M.A.; Schwarz, P.E.; Shuldiner, A.R.; Staessen, J.A.; Steinthorsdottir, V.; Stolk, R.P.; Strauch, K.; Tonjes, A.; Tremblay, A.; Tremoli, E.; Vohl, M.C.; Volker, U.; Vollenweider, P.; Wilson, J.F.; Witteman, J.C.; Adair, L.S.; Bochud, M.; Boehm, B.O.; Bornstein, S.R.; Bouchard, C.; Cauchi, S.; Caulfield, M.J.; Chambers, J.C.; Chasman, D.I.; Cooper, R.S.; Dedoussis, G.; Ferrucci, L.; Froguel, P.; Grabe, H.J.; Hamsten, A.; Hui, J.; Hveem, K.; Jockel, K.H.; Kivimaki, M.; Kuh, D.; Laakso, M.; Liu, Y.; Marz, W.; Munroe, P.B.; Njolstad, I.; Oostra, B.A.; Palmer, C.N.; Pedersen, N.L.; Perola, M.; Perusse, L.; Peters, U.; Power, C.; Quertermous, T.; Rauramaa, R.; Rivadeneira, F.; Saaristo, T.E.; Saleheen, D.; Sinisalo, J.; Slagboom, P.E.; Snieder, H.; Spector, T.D.; Thorsteinsdottir, U.; Stumvoll, M.; Tuomilehto, J.; Uitterlinden, A.G.; Uusitupa, M.; van der Harst, P.; Veronesi, G.; Walker, M.; Wareham, N.J.; Watkins, H.; Wichmann, H.E.; Abecasis, G.R.; Assimes, T.L.; Berndt, S.I.; Boehnke, M.; Borecki, I.B.; Deloukas, P.; Franke, L.; Frayling, T.M.; Groop, L.C.; Hunter, D.J.; Kaplan, R.C.; O'Connell, J.R.; Qi, L.; Schlessinger, D.; Strachan, D.P.; Stefansson, K.; van Duijn, C.M.; Willer, C.J.; Visscher, P.M.; Yang, J.; Hirschhorn, J.N.; Zillikens, M.C.; McCarthy, M.I.; Speliotes, E.K.; North, K.E.; Fox, C.S.; Barroso, I.; Franks, P.W.; Ingelsson, E.; Heid, I.M.; Loos, R.J.; Cupples, L.A.; Morris, A.P.; Lindgren, C.M.; Mohlke, K.L.   
  Title New genetic loci link adipose and insulin biology to body fat distribution Type Journal Article
  Year 2015 Publication Nature Abbreviated Journal Nature  
  Volume 518 Issue 7538 Pages 187-196  
  Keywords HUNT3; Adipocytes/metabolism; Adipogenesis/genetics; Adipose Tissue/*metabolism; Age Factors; *Body Fat Distribution; Body Mass Index; Continental Population Groups/genetics; Epigenesis, Genetic; Europe/ethnology; Female; Genome, Human/genetics; *Genome-Wide Association Study; Humans; Insulin/*metabolism; Insulin Resistance/genetics; Male; Models, Biological; Neovascularization, Physiologic/genetics; Obesity/genetics; Polymorphism, Single Nucleotide/genetics; Quantitative Trait Loci/*genetics; Sex Characteristics; Transcription, Genetic/genetics; Waist-Hip Ratio  
  Abstract Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication 1] Department of Public Health and Clinical Medicine, Unit of Medicine, Umea University, 901 87 Umea Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Shungin2015 Serial 1858  
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