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Author (up) Skarpengland, T.; Laugsand, L.E.; Janszky, I.; Luna, L.; Halvorsen, B.; Platou, C.G.; Wang, W.; Vatten, L.J.; Damas, J.K.; Aukrust, P.; Bjoras, M.; Asvold, B.O. url  doi
  Title Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study Type Journal Article
  Year 2015 Publication DNA Repair (Amst) Abbreviated Journal DNA repair  
  Volume 28 Issue Pages 21-27  
  Keywords HUNT3; Atherosclerosis; DNA glycosylase; Myocardial infarction; NEIL3; SNP; Aged; Aged, 80 and over; Case-Control Studies; DNA Glycosylases/genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics; DNA-Binding Proteins/genetics; Female; Humans; Male; Middle Aged; Myocardial Infarction/*genetics; N-Glycosyl Hydrolases/*genetics; *Polymorphism, Single Nucleotide  
  Abstract BACKGROUND: Enhanced generation of reactive oxygen species and increased oxidative-induced DNA damage have been identified as possible contributors to atherosclerosis. The base excision repair (BER) pathway is the principal mechanism by which mammalian cells repair oxidative DNA damage. BER deficiency can potentially accelerate atherogenesis. METHODS: We evaluated the association of Single Nucleotide Polymorphisms (SNPs) in genes encoding four different BER proteins (NEIL3, OGG1, APEX1 and XRCC1) with the incidence of myocardial infarction in a nested case-control study among participants of the second survey of the HUNT Study. The study population included 1624 cases and 4087 age- and sex-matched controls. RESULTS: For the NEIL3 SNP rs12645561, the TT genotype was associated with increased risk of MI (OR 1.47, 95% CI 1.02-2.12, p uncorrected for multiple comparisons=0.04) both in the genotypic test (compared to the CC genotype) and in the recessive genetic model (compared to the CC and CT genotypes combined). For the other two NEIL3 SNPs (rs10013040 and rs1395479) and for the SNPs of OGG1 (rs1052133), APEX1 (rs1878703) and XRCC1 (rs25489) we observed no association with risk of myocardial infarction. CONCLUSION: We found that the NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction. If confirmed in other studies, this association may suggest a possible role of attenuated DNA repair, and NEIL3 in particular, in atherogenesis.  
  Corporate Author Thesis  
  Publisher Place of Publication Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Institute Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Skarpengland, TonjeLaugsand, Lars ErikJanszky, ImreLuna, LuisaHalvorsen, BentePlatou, Carl G PWang, WeiVatten, Lars JDamas, Jan KristianAukrust, PalBjoras, MagnarAsvold, Bjorn OENG2015/02/24 06:00DNA Repair (Amst). 2015 Feb 2;28C:21-27. doi: 10.1016/j.dnarep.2015.01.013. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Skarpengland2015 Serial 1860  
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