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Author (up) Skogen, J.C.; Bergh, S.; Stewart, R.; Knudsen, A.K.; Bjerkeset, O. url  doi
  Title Midlife mental distress and risk for dementia up to 27 years later: the Nord-Trondelag Health Study (HUNT) in linkage with a dementia registry in Norway Type Journal Article
  Year 2015 Publication BMC Geriatr Abbreviated Journal BMC geriatrics  
  Volume 15 Issue Pages 23  
  Keywords Adult; Aged; Dementia/*epidemiology; Female; Humans; Logistic Models; Male; Middle Aged; Norway/epidemiology; Odds Ratio; *Registries; Risk Factors; Self Report; Stress, Psychological/*psychology; Time Factors  
  Abstract BACKGROUND: Dementia is an increasing public health challenge, and the number of individuals affected is growing rapidly. Mental disorders and symptoms of mental distress have been reported to be risk factors for dementia. The aim of this study was to examine whether midlife mental distress is a predictor for onset of dementia later in life. METHODS: Using data from a large population-based study (The Nord-Trondelag Health Study; HUNT1) linked to a dementia registry (The Health and Memory study; HMS) enabling a maximum 27 years of follow-up, we ascertained mental distress and subsequent dementia status for 30,902 individuals aged 30-60 years at baseline. In HUNT1, self-reported mental distress was assessed using the four-item Anxiety and Depression Index (ADI-4). Dementia status was ascertained from HMS, which included patient and caregiver history, cognitive testing and clinical and physical examinations from the hospitals and nursing homes serving the catchment area of HUNT1. In the main analysis, unadjusted and adjusted logistic regression models were computed for the prospective association between mental distress and dementia. In secondary analyses, two-way age and gender interactions with mental distress on later dementia were examined. RESULTS: A 50% increased odds for dementia among HUNT1-participants reporting mental distress was found (crude odds ratio (OR): 1.52; 95% CI 1.15-2.01), and a 35% increase in the fully adjusted model (OR 1.35; 95% CI 1.01-1.80). In secondary analyses, we found evidence for a two-way interaction with age on the association between mental distress and dementia (p = 0.030): the age- and gender adjusted OR was 2.44 (95% CI 1.18-5.05) in those aged 30-44 years at baseline, and 1.24 (0.91-1.69) in 45-60 year olds. CONCLUSIONS: Our results indicate an association between midlife mental distress and increased risk of later dementia, an association that was stronger for distress measured in early compared to later midlife. Mental distress should be investigated further as a potentially modifiable risk factor for dementia.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Division of Mental Health, Department of Public Mental Health, Norwegian Institute of Public Health, Editor  
  Language Summary Language Original Title  
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  Series Volume Series Issue Edition  
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  Area Expedition Conference  
  Notes Skogen, Jens ChristofferBergh, SverreStewart, RobertKnudsen, Ann KristinBjerkeset, OttarengResearch Support, Non-U.S. Gov'tEngland2015/04/19 06:00BMC Geriatr. 2015 Mar 10;15:23. doi: 10.1186/s12877-015-0020-5. Approved no  
  Call Number HUNT @ maria.stuifbergen @ Skogen2015 Serial 1861  
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